Vet World   Vol.10   August-2017  Article-27

Potential of pomegranate fruit extract (Punica granatum Linn.) to increase vascular endothelial growth factor and platelet-derived growth factor expressions on the post-tooth extraction wound of Cavia cobaya

Background and Aim: To investigate the potential of pomegranate extracts on the tooth extraction wound to increase the expression of VEGF and PDGF on the 4th day of wound healing process.

Materials and Methods: This study used 12 Cavia cobaya, which were divided into two groups, namely, the provision of 3% sodium carboxymethyl cellulose and pomegranate extract. The 12 C. cobaya would be executed on the 4th day, the lower jaw of experimental animals was taken, decalcified about 30 days. The expression of VEGF and PDGF was examined using immunohistochemical techniques. The differences of VEGF and PDGF expression were evaluated statistically using t-test.

Results: Statistically analysis showed that there were significant differences between control and treatment groups (p<0.05).

Conclusion: Pomegranate fruit extract administration increased VEGF and PDGF expression on post-tooth extraction wound. Keywords: platelet-derived growth factor, Punica granatum Linn. fruit, tooth extraction wound, vascular endothelial growth factor.

Keywords: platelet-derived growth factor, Punica granatum Linn. fruit, tooth extraction wound, vascular endothelial growth factor.

How to cite this article: Nirwana I, Rachmadi P, Rianti D (2017) Potential of pomegranate fruit extract (Punica granatum Linn.) to increase vascular endothelial growth factor and platelet-derived growth factor expressions on the post-tooth extraction wound of Cavia cobaya, Veterinary World, 10(8): 999-1003.

Received: 08-03-2017  Accepted: 01-08-2017     Published online: 27-08-2017

Corresponding author: Intan Nirwana   E-mail: intannirwana@ymail.com

DOI: 10.14202/vetworld.2017.999-1003

Copyright: Nirwana, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.