Vet World   Vol.10   June-2017  Article-12

Induced pluripotent stem cell: A headway in reprogramming with promising approach in regenerative biology

Background and Aim: Since the embryonic stem cells have knocked the doorsteps, they have proved themselves in the field of science, research, and medicines, but the hovered restrictions confine their application in human welfare. Alternate approaches used to reprogram the cells to the pluripotent state were not up to par, but the innovation of induced pluripotent stem cells (iPSCs) paved a new hope for the researchers. Soon after the discovery, iPSCs technology is undergoing renaissance day by day, i.e., from the use of genetic material to recombinant proteins and now only chemicals are employed to convert somatic cells to iPSCs. Thus, this technique is moving straightforward and productive at an astonishing pace. Here, we provide a brief introduction to iPSCs, the mechanism and methods for their generation, their prevailing and prospective applications and the future opportunities that can be expected from them.

Keywords: cellular reprogramming, embryonic stem cells, induced pluripotent stem cells, stem cells.

How to cite this article: Rawat N, Singh MK (2017) Induced pluripotent stem cell: A headway in reprogramming with promising approach in regenerative biology, Veterinary World, 10(6): 640-649.

Received: 04-02-2017  Accepted: 26-04-2017     Published online: 14-06-2017

Corresponding author: M. K. Singh   E-mail: drmanojvet@gmail.com

DOI: 10.14202/vetworld.2017.640-649

Copyright: Rawat and Singh, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.