Open Access
Review (Published online: 14-06-2017)
12. Induced pluripotent stem cell: A headway in reprogramming with promising approach in regenerative biology
N. Rawat and M. K. Singh
Veterinary World, 10(6): 640-649

N. Rawat: Embryo Biotechnology Lab, Animal Biotechnology Centre, ICAR - National Dairy Research Institute, Karnal - 132 001, Haryana, India.
M. K. Singh: Embryo Biotechnology Lab, Animal Biotechnology Centre, ICAR - National Dairy Research Institute, Karnal - 132 001, Haryana, India.

doi: 10.14202/vetworld.2017.640-649

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Article history: Received: 04-02-2017, Accepted: 26-04-2017, Published online: 14-06-2017

Corresponding author: M. K. Singh


Citation: Rawat N, Singh MK (2017) Induced pluripotent stem cell: A headway in reprogramming with promising approach in regenerative biology, Veterinary World, 10(6): 640-649.

Since the embryonic stem cells have knocked the doorsteps, they have proved themselves in the field of science, research, and medicines, but the hovered restrictions confine their application in human welfare. Alternate approaches used to reprogram the cells to the pluripotent state were not up to par, but the innovation of induced pluripotent stem cells (iPSCs) paved a new hope for the researchers. Soon after the discovery, iPSCs technology is undergoing renaissance day by day, i.e., from the use of genetic material to recombinant proteins and now only chemicals are employed to convert somatic cells to iPSCs. Thus, this technique is moving straightforward and productive at an astonishing pace. Here, we provide a brief introduction to iPSCs, the mechanism and methods for their generation, their prevailing and prospective applications and the future opportunities that can be expected from them.

Keywords: cellular reprogramming, embryonic stem cells, induced pluripotent stem cells, stem cells.


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