Article history: Received: 01-12-2016, Accepted: 20-03-2017, Published online: 07-05-2017
Corresponding author: A. Manimaran
E-mail: email@example.comCitation: Kumar N, Manimaran A, Sivaram M, Kumaresan A, Jeyakumar S, Sreela L, Mooventhan P, Rajendran D (2017) Influence of clinical mastitis and its treatment outcome on reproductive performance in crossbred cows: A retrospective study, Veterinary World, 10(5): 485-492.
Aim: Evaluation of the effect of clinical mastitis (CM) and its treatment outcome on the reproductive performance in crossbred cows retrospectively.
Materials and Methods: Datasets of 835 lactating cows affected with CM during a period of 12 years (2001-2012) were considered for this study. Mastitis treatment related data and reproductive parameters such as days to first detected heat (DTFDH), days to first insemination (DTFI), days open (DO), and number of services per conception (SC) were collected from mastitis treatment and artificial insemination registers, respectively. Data were analyzed by ANOVA using SPSS 20 software. The means were compared with the Duncan's multiple comparison post-hoc test.
Results: CM affected cows had significantly (p<0.05) higher DTFDH, DTFI, DO and SC compared to clinically healthy cows. Cows diagnosed with a single episode of CM had significantly (p<0.05) delayed DTFDH while, DO and SC were significantly higher (p<0.05) in cows diagnosed by multiple episodes of CM. SC was significantly (p<0.05) higher in cows diagnosed with both relapse and recurrence. Severe CM affected cows had significantly (p<0.05) altered reproductive parameters. The reproductive parameters were altered to high extent when CM occurred during the breeding period.
Conclusion: CM-affected cows had higher DTFDH, DTFI, DO and SC compared to clinically healthy cows. The negative effects of CM on reproduction parameters were higher when CM occurred during the breeding period.
Keywords: clinical mastitis, crossbred cows, reproductive parameters, retrospective study.
1. Chebel, R.C., Santos, J.E., Reynolds, J.P., Cerri, R.L., Juchem, S.O. and Overton, M. (2004) Factors affecting conception rate after artificial insemination and pregnancy loss in lactating dairy cows. Anim. Reprod. Sci., 84: 239-255. [Crossref] [PubMed]
2. Moore, D.A., Cullor, J.S., Bondurant, R.H. and Sischo, W.M. (1991) Preliminary field evidence for the association of clinical mastitis with altered interestrus intervals in dairy cattle. Theriogenology, 36: 257-265. [Crossref]
3. Podpecan, O., Mrkun, J. and Zrimsek, P. (2013) Associations between the fat to protein ration in milk, health status and reproductive performance in dairy cattle. Slov. Vet. Res., 50: 57-66.
4. Gomez-Cifuentes, M.C.I., Signorini, A.I., Scandolo, M.L. and Calvinho, D.L.F. (2014) The association between mastitis and reproductive performance in seasonally-calved dairy cows managed on a pasture-based system. Arch. Med. Vet., 46: 197-206. [Crossref]
5. Manimaran, A., Kumaresan, A., Sreela, L., Boopathi, V. and Prakash, M.A. (2014) Effects of clinical mastitis on days open in dairy cattle and buffaloes. Indian Vet. J., 91: 67-68.
6. Boujenane, I., El Aimani, J. and By, K. (2015) Effects of clinical mastitis on reproductive and milk performance of Holstein cows in Morocco. Trop. Anim. Health Prod., 47: 207-211. [Crossref] [PubMed]
7. Santos, J.E.P., Cerri, R.L.A., Ballou, M.A., Higginbotham, G.E. and Kirk, J.H. (2004) Effect of timing of first clinical mastitis occurrence on lactational and reproductive performance of Holstein dairy cows. Anim. Reprod. Sci., 80: 31-45. [Crossref]
8. Moore, D.A., Overton, M.W., Chebel, R.C., Truscott, M.L. and Bon Durant, R.H. (2005) Evaluation of factors that affect embryonic loss in dairy cattle. J. Am. Vet. Med. Assoc., 226: 1112-1118. [Crossref] [PubMed]
9. Nava-Trujillo, H., Soto-Belloso, E. and Hoet, A.E. (2010) Effects of clinical mastitis from calving to first service on reproductive performance in dual-purpose cows. Anim. Reprod. Sci., 121: 12-16. [Crossref] [PubMed]
10. Hertl, J.A., Grohn, J.A., Leach, J.A., Bar, D., Bennett, G.J., Gonzalez, R.N., Rauch, B.J., Welcome, F.L., Tauer, L.W. and Schukken, Y.H. (2010) Effects of clinical mastitis caused by gram-positive and gram-negative bacteria and other organisms on the probability of conception in New York State Holstein dairy cows. J. Dairy Sci., 93: 1551-1560. [Crossref]
11. Lavon, Y., Ezra, E., Leitner, G. and Wolfenson, D. (2011) Association of conception rate with pattern and level of somatic cell count elevation relative to time of insemination in dairy cows. J. Dairy Sci., 94(9): 4538-4545. [Crossref] [PubMed]
12. Hudson, C.D., Bradley, A.J., Breen, J.E. and Green, M.J. (2012) Associations between udder health and reproductive performance in United Kingdom dairy cows. J. Dairy Sci., 95: 3683-3697. [Crossref] [PubMed]
13. Upadhyay, R.C., Singh, S.V., Kumar, A., Gupta, S.K. and Ashutosh, A. (2007) Impact of climate change on milk production of Murrah buffaloes. Ital. J. Anim. Sci., 6: 1329-1332. [Crossref]
14. Haque, N. (2015) Studies on Seasonal Stress-induced Changes on Plasma Hormones, Metabolites and Milk Plasminoge-plasmin System in Murrah Buffaoles. PhD Thesis, Submitted to National Dairy Research Institute.
15. NRC. (2001) Nutrients Requirement of Dairy Cattle. 7th ed. National Academy Press, Washington, DC.
16. Layek, S.S., Mohanty, T.K., Kumaresan, A., Behera, K. and Chand, S. (2013) Cervical mucus characteristics and periestrual hormone concentration in relation to ovulation time in Zebu (Sahiwal) cattle. Livest. Sci., 152(2): 273-281. [Crossref]
17. Vacek, M., Stadnik, L. and Stipk, M. (2007) Relationships between the incidence of health disorders and the reproduction traits of Holstein cows in the Czech Republic. Czech J. Anim. Sci., 52: 227-235.
18. Hansen, P.J., Soto, P. and Natzke, R.P. (2004) Mastitis and fertility in cattle - Possible involvement of inflammation or immune activation in embryonic mortality. Am. J. Reprod. Immunol., 51: 294-301. [Crossref] [PubMed]
19. Huszenicza, G.Y., Janosi, S.Z., Kulcsar, M., Korodi, P., Dieleman, S.J., Bartyik, J. and Ribiczei-Szabo, P. (1998) Gram negative mastitis in early lactation may interfere with ovarian and certain endocrine functions and metabolism in dairy cows. Reprod. Domest. Anim., 33: 147-153. [Crossref]
20. Schrick, F., Hockett, M., Saxton, A., Lewis, M., Dowlen, H. and Oliver, S. (2001) Influence of subclinical mastitis during early lactation on reproductive parameters. J. Dairy Sci., 84: 1407-1412. [Crossref]
21. Ahmadzadeh, A., Frago, F., Shafii, B., Dalton, J.C., Price, W.J. and McGuire, M.A. (2009) Effect of clinical mastitis and other diseases on reproductive performance of Holstein cows. Anim. Reprod. Sci., 112: 273-282. [Crossref] [PubMed]
22. Gunay, A. and Gunay, U. (2008) Effects of clinical mastitis on reproductive performance in Holstein cows. Acta Vet. Brno, 77: 555-560. [Crossref]
23. Deluyker, H.A., Van Oye, S.N. and Boucher, J.F. (2005) Factors affecting cure and somatic cell count after pirlimycin treatment of subclinical mastitis in lactating cows. J. Dairy Sci., 88: 604-614. [Crossref]
24. Bradley, A.J. and Green, M.J. (2009) Factors affecting cure when treating bovine clinical mastitis with cephalosporin-based intramammary preparations. J. Dairy Sci., 92: 1941-1953. [Crossref] [PubMed] [PMC]
25. Moussavi, A.H., Mesgaran, M.D. and Gilbert, R.O. (2012) Effect of mastitis during the first lactation on production and reproduction performance of Holstein cows. Trop. Anim. Health Prod., 44: 1567-1573. [Crossref] [PubMed]
26. Lago, A., Godden, S.M., Bey, R., Ruegg, P.L. and Leslie, K. (2011) The selective treatment of clinical mastitis based on on-farm culture results: I. Effects on antibiotic use, milk withholding time, and short-term clinical and bacteriological outcomes. J. Dairy Sci., 94: 4441-4456. [Crossref]
30. Fuenzalida, M.J., Fricke, P.M. and Ruegg, P.L. (2015) The association between occurrence and severity of subclinical and clinical mastitis on pregnancies per artificial insemination at first service of Holstein cows. J. Dairy Sci., 98: 3791-3805. [Crossref]
31. Frago, F., Ahmadzadeh, A., Shafii, B., Dalton, J.C., McGuire, M.A. and Price, W.J. (2004) Effect of clinical mastitis and other diseases on reproductive performance of Holstein cows. J. Dairy Sci., 87: 258.
32. Yang, F.L., Li, X.S., Yang, B.Z., Zhang, Y., Zhang, X.F., Qin, G.S. and Liang, X.W. (2012) Clinical mastitis from calving to next conception negatively affected reproductive performance of dairy cows in Nanning, China. Afr. J. Biotechnol., 11: 2574-2580. [Crossref]
33. Barker, A., Schrick, F., Lewis, M., Dowlen, H. and Oliver, S. (1998) Influence of clinical mastitis during early lactation on reproductive performance of Jersey cows. J. Dairy Sci., 81: 1285-1290. [Crossref]
34. Risco, C.A., Donovan, G.A. and Hernandez, J. (1999) Clinical mastitis associated with abortion in dairy cows. J. Dairy Sci., 82: 1684-1689. [Crossref]
35. Ranjan, R., Gupta, M.K. and Singh, K.K. (2011) Study of bovine mastitis in different climatic conditions in Jharkhand, India. Vet. World, 4: 205-208. [Crossref]
37. Edwards, J.L. and Hansen, P.J. (1997) Differential responses of bovine oocytes and preimplantation embryos to heat shock. Mol. Reprod. Dev., 46: 138-145. [Crossref]
38. Krininger, C.E., Stephens, S.H. and Hansen, P.J. (2002) Developmental changes in inhibitory effects of arsenic and heat shock on growth of preimplantation bovine embryos. Mol. Reprod. Dev., 63: 335-340. [Crossref] [PubMed]
39. Al-Katanani, Y.M., Paula-Lopes, F.F. and Hansen, P.J. (2002) Effect of season and exposure to heat stress on oocyte competence in Holstein cows. J. Dairy Sci., 85: 390-396. [Crossref]
40. Gendelman, M., Aroyo, A., Yavin, S. and Roth, Z. (2010) Seasonal effects on gene expression, cleavage timing, and developmental competence of bovine preimplantation embryos. Reproduction, 140: 73-82. [Crossref] [PubMed]41. Maltz, E., Devir, S., Metz, J.H.M. and Hogeveen, H. (1997) The body weight of the dairy cow. Introductory study into body weight changes in dairy cows as a management aid. Livest. Prod. Sci., 48: 175. [Crossref]