Article history: Received: 24-04-2017, Accepted: 07-09-2017, Published online: 26-09-2017
Corresponding author: Mourad Zeghdoudi
E-mail: email@example.comCitation: Zeghdoudi M, Aoun L, Merdaci L, Bouzidi N (2017) Epidemiological features and pathological study of avian leukosis in turkeys' flocks, Veterinary World, 10(9): 1135-1138.
Aim: The purpose of this study was focused on the identification of tumor diseases in turkeys on the basis of a detailed description of epidemiological features, clinical signs, lesions, and histopathological changes.
Materials and Methods: Outbreak of a tumor disease in turkeys was investigated in various regions of Eastern Algeria. Four turkeys' flocks aged from 17 weeks were affected, resulting to mortality often over 10%, on a period of 15 days. The main epidemiological characters, clinical signs, and lesions were observed throughout all the course of the disease. Serum samples were collected from affected turkeys in each flock to detect p27 antigen in enzyme-linked immunosorbent assay (ELISA) test to diagnose avian leukosis virus (ALV). Portions of sciatic nerves and livers are taken from dead turkeys for microscopic examination.
Results: The disease was characterized by clinical signs such as anorexia, weakness, and diarrhea. Necropsy of the dead birds showed hepatomegaly and gross splenomegaly with neoplastic nodules or gray foci and diffuse infiltration in the myocardium and lungs. ALV antigen test using ELISA confirmed the presence of virus leukosis. Histopathological sections of the liver had proliferations of lymphoblastoid cells and absence of any modifications or lymphocytic infiltration in peripheral nerves.
Conclusion: The present study confirms that this disease condition is caused by lymphoid leukosis.
Keywords: enzyme-linked immunosorbent assay, epidemiological features, histopathology, lesions, leukosis, turkeys.
1. Feng, M. and Zhang, X. (2016) Immunity to avian Leukosis virus: Where are we now and what should we do? Front Immunol., 21: 7-624. [PubMed]
3. Schat, K.A. and Erb, H.N. (2014) Lack of evidence that avian oncogenic viruses are infectious for humans: A review. Avian Dis., 58: 345-358. [Crossref]
4. Biggs, P.M. (1976) Criteria for the differential diagnosis of lymphoid Leukosis and Marek's disease. In: Payne, L.N., editor. Differential Diagnosis of Avian Lymphoid Leukosis and Marek's Disease. Agricultural Research Service, Washington, D. C. p67-85.
7. Fadly, A.M. (1997) Criteria for the Differential Diagnosis of Viral Lymphomas of Chickens. In: Fadly, A.M., Schat, K.A. and Spencer, J.L., editors. Proceedings Avian Tumor Viruses' Symposium. Reno, Nevada. p6-11.
8. Dambrine, G. (1992) Lymphocytic tumors in Turkeys. In: Brugere-Picoux, J. and Silim, A., editors. 1st ed. Manual of Avian Pathology. Maisons-Alfort, Paris. p185-191.
13. Sathish Gopal, S., Manoharan, P., Kathaperumal, K., Chidambaram, B. and Divya, K.C. (2012) Differential detection of avian oncogenic viruses in poultry layer farms and turkeys by PCR. J. Clin. Microbiol., 50: 2668-2673. [Crossref] [PubMed] [PMC]14. Mays, J.K., Pandiri, A.R. and Fadly A.M. (2006) Susceptibility of various parental lines of commercial white leghorn layers to infection with a naturally occurring recombinant Avian leukosis virus containing subgroup B envelope and subgroup J long terminal repeat. Avian Dis., 50: 342-7. [Crossref]