Open Access
Review (Published online: 26-06-2018)
19. Insights into pH regulatory mechanisms in mediating spermatozoa functions
Abhishek Kumar Mishra, Akshay Kumar, Dilip Kumar Swain, Sarvajeet Yadav and Rajesh Nigam
Veterinary World, 11(6): 852-858

Abhishek Kumar Mishra: College of Biotechnology, U.P. Pandit Deendayal Upadhayaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan, Mathura - 281 001, Uttar Pradesh, India.
Akshay Kumar: Department of Gynaecology and Obstetrics, College of Veterinary Sciences and Animal Husbandry, U.P. Pandit Deendayal Upadhayaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan, Mathura - 281 001, Uttar Pradesh, India.
Dilip Kumar Swain: Department of Physiology, College of Veterinary Sciences and Animal Husbandry, U.P. Pandit Deendayal Upadhayaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan, Mathura - 281 001, Uttar Pradesh, India.
Sarvajeet Yadav: Department of Physiology, College of Veterinary Sciences and Animal Husbandry, U.P. Pandit Deendayal Upadhayaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan, Mathura - 281 001, Uttar Pradesh, India.
Rajesh Nigam: College of Biotechnology, U.P. Pandit Deendayal Upadhayaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan, Mathura - 281 001, Uttar Pradesh, India.

doi: 10.14202/vetworld.2018.852-858

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Article history: Received: 13-02-2018, Accepted: 17-05-2018, Published online: 26-06-2018

Corresponding author: Dilip Kumar Swain


Citation: Mishra AK, Kumar A, Swain DK, Yadav S, Nigam R (2018) Insights into pH regulatory mechanisms in mediating spermatozoa functions, Veterinary World, 11(6): 852-858.

Regulation of pH in spermatozoa is a complex and dynamic process as sperm cells encounter different pH gradients during their journey from testes to the site of fertilization in female genital tract. The precise regulations of pH in sperm cells regulate the sperm functions such as motility, hyperactivity, capacitation, and acrosome reaction. Electrophysiological, pharmacological, and molecular studies have revealed the presence of different ion channels and exchanger systems which regulate intracellular pH in sperm cells as well as regulate sperm functions. Recent studies also have shown the potential involvement of pH in the regulation of fertility competence of sperm cells, and alterations in pH have shown to impede sperm functions. This mini-review discusses the probable mechanisms involved in pH regulation in sperm cells and how pH is involved in regulation of various sperm functions.

Keywords: acrosome reaction, capacitation, fertilization, pH, sperm motility, spermatozoa.


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