Article history: Received: 31-03-2018, Accepted: 25-05-2018, Published online: 30-06-2018
Corresponding author: Sofiane Boudjellaba
E-mail: email@example.comCitation: Boudjellaba S, Ainouz L, Tennah S, Temim S, Iguer-Ouada M (2018) Reproduction performance and blood biochemical parameters in dairy cows: Relationship with oxidative stress status, Veterinary World, 11(6): 883-888.
Background and Aim: During the last decades, reproduction performances declined dramatically worldwide, but little is known concerning the involvement of oxidative stress as a causative factor. Oxidative stress may act at different levels, with negative impacts on cell membrane integrity and other active molecules with potential subsequent effects on reproduction. The aim of the current study was to investigate the oxidative stress status in cows according to their reproductive performances.
Materials and Methods: Peripheral blood concentration of two oxidative stress biomarkers, glutathione S-transferase (GST) and malondialdehyde (MDA), and other biochemical parameters (glucose, total lipids, cholesterol, triglycerides, albumin, total proteins, calcium, urea, creatinine, direct bilirubin, alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase) were determined in 40 healthy cows. Body condition score (BCS), calving to first service interval (FSI), calving to conception interval (CCI), and the number of service per conception (SPC) were simultaneously recorded for each cow.
Results: Concerning FSI, three groups were established: Group 1 (from 44 to 60 days), Group 2 (from 60 to 70 days), and Group 3 (from 70 to 80 days). For CCI, two groups were considered: Group 1 (<110 days) and Group 2 (>110 days). MDA showed significant high values only in cows with the lowest BCS (1.5) compared to cows with BCS note of 2.5 and 3.5. No significant difference was observed in cows oxidative stress status (MDA and GST) according to reproductive performances (FSI, CCI, and SPC) in all studied groups.
Conclusion: The results revealed relatively altered oxidative stress status in cows with abnormal reproductive performances; however, no significant difference was recorded whatever the considered reproductive parameter.
Keywords: cow, glutathione S-transferase, malondialdehyde, reproduction performance.
1. Betteridge, J. (2000) What is oxidative stress? Metabolism, 49(2) Suppl 1: 3-8. [Crossref]
2. Zhong, R. and Zhou, D. (2013) Oxidative stress and role of natural plant-derived antioxidants in animal reproduction. J. Integr. Agric., 12(10): 1826-1838. [Crossref]
4. Talukder, S., Kerrisk, K.L., Ingenhoff, L., Gabai, G., Garcia, S. and Celi, P. (2014) Changes in plasma oxidative stress biomarkers in dairy cows after oestrus synchronisation with controlled internal drug release (CIDR) and prostaglandinF2a (PGF2a). Anim. Prod. Sci., 54(9): 1490-1496.
5. Colakoglu, H.E., Yazlik, M.O., Kaya, U., Colakoglu, E.C., Kurt, S., Oz, B., Bayramoglu, R., Vural, M.R. and Kuplul, S. (2017) MDA and GSH-Px activity in transition dairy cows under seasonal variations and their relationship with reproductive performance. J. Vet. Res., 61: 497-502. [Crossref]
6. Nayki, C., Nayki, U., Gunay, M., Kulhan, M., Cankaya, M., Humeyra, T.K.A. and Balci, G. (2017) Oxidative and antioxidative status in the endometrium of patients with benign gynaecological disorders. J. Gynecol. Obstet. Hum. Reprod., 46: 243-247. [Crossref] [PubMed]
7. Aydilek, N., Varisli, O., Selek, S., Korkmaz, O., Atli, M.O. and Taskin, A. (2014) The effect of estrus cycle on oxidant and antioxidant parameters in dairy cows. Kafkas. Univ. Vet. Fak. Derg., 20(5): 703-709.
8. McDougall, S. (2006) Reproduction performance and management of dairy cattle. J. Reprod. Dev., 52(1): 185-194. [Crossref]
9. Lucy, M.C. (2001) Reproductive loss in high-producing dairy cattle: Where will it end? J. Dairy. Sci., 84: 1277-1293. [Crossref]
10. Chebel, R.C., Silva, P.R.B., Endres, M.I., Ballou, M.A. and Luchterhand, K.L. (2016) Social stressors and their effects on immunity and health of periparturient dairy cows. J. Dairy. Sci., 99: 1-12. [Crossref] [PubMed]
11. Wildman, E.E., Jones, G.M., Wagner, P.E. and Boman, R.L. (1982) A dairy cow body condition scoring system and its relationship to selected production characteristics. J. Dairy. Sci., 65: 495-501. [Crossref]
12. Ohkawa, H., Ohishi, W., Yagi, K. (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem., 95(2): 351-358. [Crossref]
13. Habig, W.H., Pabst, M.J., Jakoby, W.B. (1974) Glutathione S-transferases: The first enzymatic step in mercapturic acid formation. J. Biol. Chem., 249: 7130-7139. [PubMed]
14. Turk, R., Juretic, D., Geres, D., Svetina, A., Turk, N. and Flegar-Mestric, Z. (2008) Influence of oxidative stress and metabolic adaptation on PON1 activity and MDA level in transition dairy cows. Anim. Reprod. Sci., 108: 98-106. [Crossref] [PubMed]
15. Folnozic, I., Turk, R., Duricic, D., Vince, S., Pleadin, J., Flegar-Mestric, Z., Valpotic, H., Dobranic, T., Gracner, D. and Samardzija, M. (2015) Influence of body condition on serum metabolic indicators of lipid mobilisation and oxidative stress in dairy cows during the transition period. Reprod. Domest. Anim., 50: 910-917. [Crossref] [PubMed]
16. Al-Gubory, K.H., Garrel, C., Delatouche, L., Heyman, Y. and Chavatte-Palmer, P. (2010) Antioxidant adaptive responses of extraembryonic tissues from cloned and non-cloned bovine conceptuses to oxidative stress during early pregnancy. Reproduction. 140: 175-181. [Crossref] [PubMed]
17. Bernabucci, U., Ronchi, B., Lacetera, N. and Nardone, A. (2005) Influence of body condition score on relationships between metabolic status and oxidative stress in periparturient dairy cows. J. Dairy. Sci., 88: 2017-2026. [Crossref]
18. Tanh, T., Amanlou, H., Chamani, M., Ebrahimnezhad, Y., Salamatdost, R., Maheri, N. and Fathi, M. (2011) Effect of glutamine enhancement on oxidative stress and reproduction in Holstein dairy cows during transition period. J. Anim. Vet. Adv., 10(21): 2838-2845.
19. Celi, P., Merlo, M., Barbato, O. and Gabai, G. (2012) Relationship between oxidative stress and the success of artificial insemination in dairy cows in a pasture-based system. Vet. J., 193: 498-502. [Crossref] [PubMed]
20. Castro, N.A., Pfeifer, L.F.M., Andrade, J.S., Rincon, J.A.A., Cantarelli, P.L.M. and Schneider A. (2018) Efect of serum paraoxonase-1 (PON1) activity on follicular development and pregnancy rate in cattle. Anim. Prod. Sci., 188: 130-136. [Crossref]
21. Castillo, C., Hernandez, J., Bravo, A., Lopez-Alonso, M., Pereira, V. and Benedito, J.L. (2005) Oxidative status during late pregnancy and early lactation in dairy cows. Vet. J., 169: 286-292. [Crossref] [PubMed]22. O'Boyle, N., Corl, C.M., Gandy, J.C. and Sordillo, L.M. (2006) Relationship of body condition score and oxidant stress to tumor necrosis factor expression in dairy cattle. Vet. Immunol. Immunopathol., 113: 297-304. [Crossref] [PubMed]