Open Access
Research (Published online: 26-04-2021)
27. Determination of natural antibodies, beta-hydroxybutyric acid, and non-esterified fatty acid levels in the serum of peripartum Tuj and Hemşin sheep
Cihan Kaçar, Semra Kaya, Mushap Kuru, Ekin Emre Erkiliç, Metin Öğün, Hasan Oral and Murat Can Demir
Veterinary World, 14(4): 1002-1006

Cihan Kaçar: Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Kafkas University, 36100 Kars, Turkey.
Semra Kaya: Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Kafkas University, 36100 Kars, Turkey.
Mushap Kuru: Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Kafkas University, 36100 Kars, Turkey.
Ekin Emre Erkiliç: Department of Internal Medicine, Faculty of Veterinary Medicine, Kafkas University, 36100 Kars, Turkey.
Metin Öğün: Department of Biochemistry, Faculty of Medicine, Kafkas University, 36100 Kars, Turkey.
Hasan Oral: Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Kafkas University, 36100 Kars, Turkey.
Murat Can Demir: Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Kafkas University, 36100 Kars, Turkey.

doi: www.doi.org/10.14202/vetworld.2021.1002-1006

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Article history: Received: 18-11-2020, Accepted: 04-03-2021, Published online: 26-04-2021

Corresponding author: Semra Kaya

E-mail: semra-kafkas@hotmail.com

Citation: Kaçar C, Kaya S, Kuru M, Erkiliç EE, Öğün M, Oral H, Demir MC (2021) Determination of natural antibodies, beta-hydroxybutyric acid, and non-esterified fatty acid levels in the serum of peripartum Tuj and Hemsin sheep, Veterinary World, 14(4): 1002-1006.
Abstract

Background and Aim: Many metabolic and immunological changes occur during the transition period. Innate immunity plays an important role against to infections and natural antibodies (NAb) are important in immunity. This study aims to determine a connection between serum NAb titers, beta-hydroxybutyric acid (BHBA), and non-esterified fatty acid (NEFA) concentrations in Tuj and Hemsin sheep during the peripartum period.

Materials and Methods: Serum NAb, BHBA, and NEFA levels were determined from the blood samples collected from Tuj and Hemsin sheep on days 30 and 15 before birth, on the day of birth (day 0), and on days 15 and 30 after birth.

Results: NAb titers were found to be higher in Tuj than in Hemsin sheep (p<0.001). No statistically significant difference was found in serum BHBA concentrations of both breeds on all sampling days (p>0.05). The serum NEFA level was lower in Tuj sheep in the last 15 days of pregnancy compared to Hemsin sheep (p<0.05), while no difference was found in samples collected at the other time points.

Conclusion: This study indicated that serum NAb titers significantly changed in Tuj and Hemsin sheep during the transition period. Serum BHBA and NEFA concentrations increased during the last stages of pregnancy and decreased after birth. Based on these findings, it is suggested that the immunological status could vary by the breed of sheep or various factors that affect the sheep's metabolic state.

Keywords: beta-hydroxybutyric acid, ewe, natural antibody, non-esterified fatty acid, peripartum period.