Veterinary World, Vol.2 (3): 100-102

Acute toxicity study of Vilocym Premix (herbal growth promoter for Livestock)

in Wistar Albino Rat

A.H. Ahmad¹, D.S.Rekhe², K.Ravikanth², S.Maini²

Department of Pharmacology & Toxicology,

College of Veterinary & Animal Sciences, G.B.P.U.A.T., Pantnagar, Uttarakhand, India

Abstract

An experimental study with the objective of safety evaluation of Vilocym Premix, herbal growth promoter for Livestock (supplied by Ayurvet Ltd., Baddi, India), was done as per standard guidelines of OECD-423 for acute toxicity testing. Vilocym Premix is a scientifically developed combination of herbs that contains herbal ingredients namely Azadirachta indica, Curcuma longa & many more alongwith natural zeolites. The study was done in 3 males and 3 female Wistar Albino rats, which were administered an initial dose of 50 mg/kg body weight followed by dose rates of 300, 500 & 5000 mg/kg body weight of test compound. The animals were observed for signs of convulsions, tremors, circling, depression, excitement and mortality. Body weight was recorded at 0,7^th and 14^th day and plasma total protein; albumin; AST and ALT were measured after 3^rd day of experiment. No abnormal sign of symptoms were observed in any of the animal fed with Vilocym Premix at the dose rate of 50, 300, 500 & 5000 mg/kg. No mortality was observed indicating safety of herbal premix.

Keywords: Growth Promoter, Herbal, Livestock, Toxicity, Production, Weight gain.

1. Department of Pharmacology & Toxicology

2. R&D team, Ayurvet Limited, Baddi, (H.P.), India.