Veterinary World


ISSN (Online): 2231-0916


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Copyright: The authors. This article is an open access article licensed under the terms of the Creative Commons Attribution License ( which permits unrestricted use, distribution and reproduction in any medium, provided the work is properly cited.

Research (Published online : 16-05-2013)

8. Ameliorative potential of Tephrosia purpurea extract against arsenic induced toxicity in wistar rats - Ravuri Halley Gora, Sushma Lalita Baxla, Priscilla Kerketta, Reetu Toppo, Naveen Kumar and Birendra kumar Roy
Vet World. 2013; 6(8): 493-496


Aim: The present investigation has been conducted to evaluate the protective activity of Tephrosia purpurea extract (TPE) against arsenic induced toxicity.

Materials and Methods: For this study, twenty four wistar albino rats were taken. Control group, group – I rats were given sodium arsenite @ 10 mg/kg and group – II rats were treated with TPE @ 500 mg/kg along with sodium arsenite @ 10 mg/kg (daily oral for 28 days). On 29th day animals were slaughtered and various parameters were determined. Serum biomarkers, haematological parameter analysis and histomorphological examination are carried out with estimation of arsenic concentration in tissues. Results: Oral administration of sodium arsenite @ 10 mg/kg for 28 days resulted in a significant decrease in Hb%, TEC and TLC, significant increase of serum glucose, cholesterol, calcium and significant increase in arsenic accumulation in tissues. Histopathological results of intestine revealed haemorrhagic enteritis along with loss of villi. Treatment with Tephrosia purpurea @ 500 mg/kg significantly decreased the elevated glucose, LDH levels, along with significant increase haematological levels towards normal. There was reduced haemorrhagic enteritis and presence of intact villi, as compared to arsenic treated group. But there was no significant difference in serum calcium, serum cholesterol and arsenic concentration in tissues, when compared with arsenic treated group.

Conclusion: The study conclude that supplementation of TPE (500 mg/kg) daily oral for 28 days has shown protection against arsenic induced toxicity by its protective effect.

Keywords: arsenic, haematology, rats, serum bio-markers, Tephrosia purpurea, toxicity