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24. Crimean-Congo hemorrhagic fever: a comprehensive review - Aman Kamboj and Himanshu Pathak
Veterinary World, 6(10): 812-817


1. Mardani, M. and Jahromi, M.K. (2007) Crimean-Congo Hemorrhagic Fever.Archives of Iranian Medicine, 10(2): 204 – 214.
2. Ergonul, O. (2006) Crimean-Congo hemorrhagic fever. Lancet Infect Dis, 6: 203-14.
3. Hoogstraal, H. (1979) The epidemiology of tick-borne Crimean-Congo hemorrhagic fever in Asia, Europe and Africa. J Med Entomol, 15: 307–417.
4. Whitehouse, C. A. (2004) Crimean-Congo hemorrhagic fever. Antiviral Res, 64: 145–160.
5. Casals, J. (1969) Antigenic similarity between the virus causing Crimean hemorrhagic fever and Congo virus. Proc Soc Exp Biol Med, 131: 233–236.
6. Maltezou, H.C. and Papa, A. (2011) Crimean-Congo hemorrhagic fever: epidemiological trends and controversies in treatment. BMC Medicine, 9:131.
PMid:22152109 PMCid:PMC3256116
7. Leblebicioglu, H. (2010) Crimean-Congo haemorrhagic fever in Eurasia. Int J Antimicrob Agents, 36(Suppl):S43-46.
8. Zavitsanou, A., Babatsikou, F. and Koutis, C. (2009) Crimean Congo Hemorrhagic fever: an emerging tick-borne disease. Health Science Journal, 3(1):10-18.
9. Morikawa, S., Saijo, M. and Kurane, I. (2007) Recent progress in molecular biology of Crimean-Congo hemorrhagic fever. Comp ImmunolMicrobiol Infect Dis, 30: 375-89.
10. Koutis, C.H. (2007) Special Epidemiology. Editions, Technological Educational Institute of Athens. Athens, Greece.
11. Grard, G., Drexler, J.F., Fair, J., Muyembe, J.J., Wolfe, N.D., Drosten, C. and Leroy, E.M. (2011) Re-Emergence of Crimean-Congo Hemorrhagic Fever Virus in Central Africa. PLoSNegl TropDis, 5(10): e1350.
PMid:22022629 PMCid:PMC3191127
12. Nabeth, P., Cheikh, D.O., Lo, B., Faye, O., Vall, I.O.,Niang, M., Wague, B., Diop, D., Diallo, M., Diallo, B., Diop, O.M. and Simon, F.(2004) Crimean-Congo hemorrhagic fever, Mauritania. Emerg Infect Dis, 10: 2143–2149.
PMid:15663851 PMCid:PMC3323392
13. Aradaib, I.E, Erickson, B.R., Mustafa, M.E., Khristova, M.L., Saeed, N.S., Elageb, R.M. and Nichol, S.T.(2010) Nosocomial outbreak of Crimean-Congo hemorrhagic fever, Sudan. Emerg Infect Dis, 16:837–839.
14. Maltezou, H.C., Andonova, L., Andraghetti, R., Bouloy, M., Ergonul, O., Jongejan, F., Kalvatchev, N., Nichol, S., Niedrig, M., Platonov, A., Thomson, G., Leitmeyer, K. and Zeller, H. (2010) Crimean-Congo hemorrhagic fever in Europe: current situation calls for preparedness. EuroSurveill, 15(10):pii=19504.
15. Vescio, F.M., Busani, L., Mughini-Gras, L., Khoury, C., Avellis, L., Taseva, E., Rezza, G. and Christova, I. (2012) Environmental correlates of Crimean-Congo haemorrhagic fever incidence in Bulgaria. BMC Public Health, 12:1116.
PMid:23270399 PMCid:PMC3547815
16. Ozdarendeli, A., Canakoglu, N., Berber, E., Aydin, K., Tonbak, S., Ertek, M., Buzgan, T., Bolat, Y., Aktas, M. and Kalkan, A. (2010)The complete genome analysis of Crimean-Congo hemorrhagic fever virus isolated in Turkey. Virus Research, 147: 288–293.
17. ProMED-mail. Crimean-Congo hem. fever - Pakistan (09): (NW). ProMED-mail. (2010) Oct. 15. 20090715.2529.
18. Christova, I., Di Caro, A., Papa, A., Castilletti, C., Andonova, L., Kalvatchev, N.,Papadimitriou, E., Carletti, F., Mohareb, E., Capobianchi, M. R., Ippolito, G. and Rezza, G. (2009) Crimean-Congo hemorrhagic fever, southwestern Bulgaria. Emerg Infect Dis, 15:983–985.
PMid:19523314 PMCid:PMC2727343
19. Uyar, Y., Carhan, A., Albayrak, N. and Altas, A.B. (2010) Evaluation of PCR and ELISA-IgM results in the laboratory diagnosis of Crimean-Congo haemorrhagic fever cases in 2008 in Turkey. MikrobiyolBul, 44:57–64.
20. Naderi, H.R., Sarvghad, M.R., Bojdy, A., Hadizadeh, M.R., Sadeghi, R. and Sheybani, F. (2010) Nosocomial outbreak of Crimean-Congo haemorrhagic fever. Epidemiol Infect, 27: 1–5.
21. ProMED-mail. Crimean-Congo hem. fever - Kazakhstan: (SK) ProMEDmail. (2009) Jul 15. 20090715.2529.
22. ProMED-mail. Crimean-Congo hem. fever - Tajikistan: (TC). ProMED-mail. (2009) Aug 15. 20090815.2898.
23. Mustafa, M.L., Ayazi, E., Mohareb, E., Yingst, S., Zayed, A., Rossi, C.A., Schoepp, R.J., Mofleh, J., Fiekert, K., Akhbarian, Z., Sadat, H. and Leslie, T. (2011)Crimean- Congo Hemorrhagic Fever, Afghanistan, 2009. Emerging Infectious Diseases, 17 (10): 1940-41.
PMid:22000377 PMCid:PMC3310665
24. Patel, A.K., Patel, K.K., Mehta, M., Parikh, T.M., Toshniwal, H. and Patel, K. (2011) First Crimean-Congo Hemorrhagic Fever Outbreak in India. JAPI, 59: 585-88.
25. Mardani, M. and Bijani, B. (2003)Clinico-epidemiologic features and outcome analysis of hemorrhagic forms of Crimean-Congo hemorrhagic fever (CCHF) in Iran. 41st Annual Meeting of IDSA, October 9 – 12, 2003; San- Diego,United States: 763.
26. Sheikh, A.S., Sheikh, A.A., Sheikh, N.S., Rafi, U.S., Asif, M. and Afridi, F. (2005) Bi-annual surge of Crimean-Congo hemorrhagic fever (CCHF): a five-year experience. Int J Infect Dis, 9: 37-42.
27. Gubler, D.J., Reiter, P., Ebi, K.L., Yap, W., Nasci, R. and Patz, J.A. (2001) Climate variability and change in the United States: potential impacts on vector- and rodent-borne diseases. Environ Health Perspect, 109: 223 – 233.
PMid:11359689 PMCid:PMC1240669
28. Estrada-Pena, A. (2001) Forecasting habitat suitability for ticks and prevention of tick-borne diseases. VetParasitol, 98: 111 – 132.
29. Mourya, D.T., Yadav, P.D., Shete, A.M., Gurav, Y.K., Raut, C.G., Jadi, R.S., Pawar, S.D., Nichol, S.T. and Mishra, A.C. (2012) Detection, Isolation and Confirmation of Crimean- Congo Hemorrhagic Fever Virus in Human, Ticks and Animals in Ahmadabad, India, 2010–2011. PLoSNegl Trop Dis, 6(5): e1653.
30. Khan, N.A., Jaiswal, A., Choudhray, R., Abid, M. and Kishore, K. (2011) Crimean-Congo hemorrhagic fever: An article review. Int Res JPharma, 2(5): 33-40.
31. Ergonul, O. (2013)Crimean–Congo hemorrhagic fever virus: new outbreaks, new discoveries. Current Opinion in Virology, 2:215–220.
32. The Center for Food Security & Public Health. (2007) Crimean-Congo Haemorrhagic Fever. Accessed on 20-05-2013.
33. Masayuki, S., Qing, T., Bawudong, S., Lei, H. and Yuzhen, Z. (2004) Possible horizontal transmission of Crimean-Congo hemorrhagic fever virus from a mother to her child. Jpn J Infect Dis, 57: 55 – 57.
34. Marriott, A.C. and Nuttall, P.A. (1996) Molecular biology of nairoviruses. In: Elliott, R.M. (Ed.), TheBunyaviridae. Plenum Press, New York. 91–104.
35. Schmaljohn, C.S and Hooper, J.W. (2001)Bunyaviridae: the viruses and their replication. In: Knipe, D. M. andHowley, P. M. (Eds.), Fields Virology. vol. 1, fourth ed. Lippincott, Williams & Wilkins, Philadelphia. 1581–1602.
36. Yadav, P.D., Cherian, S.S., Zawar, D., Kokate, P., Gunjikar, R., Jadhav, S., Mishra, A.C. and Mourya, D.T. (2013) Genetic characterization and molecular clock analyses of the Crimean-Congo hemorrhagic fever virus from human and ticks in India, 2010–2011. Infection, Genetics and Evolution, 14: 223–231.
37. Anagnostou, V. and Papa, A. (2009) Evolution of Crimean- Congo Hemorrhagic Fever virus. Infection, Genetics and Evolution, 9: 948–954.
38. Deyde, V.M., Khristova, M.L., Rollin, P.E., Ksiazek, T.G. and Nichol, S.T. (2006) Crimean-Congo hemorrhagic fever virus genomics and global diversity. JVirol, 80: 8834–8842.
PMid:16912331 PMCid:PMC1563879
39. Swanepoel, R., Leman, P.A., Burt, F.J., Jardine, J., Verwoerd, D.J., Capua, I., Bruckner, G.K. and Burger, W.P. (1998) Experimental infection of ostriches with Crimean–Congo haemorrhagic fever virus. Epidemiol Infect, 121: 427–432.
PMid:9825796 PMCid:PMC2809542
40. World Health Organization (2013) WHO Fact Sheet No. 208. WHO, Geneva, Switzerland.
41. Van-Eeden, P.J., Joubert, J.R., Van de wal, B.W., King, J.B., de Kock, A. and Groenewald, J.H. (1985) A nosocomial outbreak of Crimean–Congo haemorrhagic fever at Tygerberg Hospital. Part I. Clinical features. S Afr Med J, 68:711–717.
42. Palomar, A.M., Portillo, A., Santibá-ez, P., Mazuelas, D., Arizaga, J., Crespo, A., Gutierrez, O., Cuadrado, J.F. and Oteo, J.A. (2013)Crimean-Congo Hemorrhagic Fever Virus in Ticks from Migratory Birds, Morocco. Emerg Infect Dis,19 (2):260-263.
PMid:23347801 PMCid:PMC3559059
43. Aradaib, I.E., Erickson, B.R., Karsany, M.S., Khristova, M.L., Elageb, R.M., Mohamed, E.H. and Nichol, S.T. (2011) Multiple Crimean-Congo Hemorrhagic Fever Virus Strains Are Associated with Disease Outbreaks in Sudan, 2008–2009. PLoSNegl Trop Dis, 5(5): e1159.
PMid:21655310 PMCid:PMC3104971
44. Saijo, M. and Morikawa, S. (2010) Recent progress in the treatment of Crimean- Congo hemorrhagic fever and future perspectives. Future virology, 5(6): 801-9.
45. Appannanavar, S.B. and Mishra, B. (2011)An Update on Crimean-Congo Hemorrhagic Fever. J Glob Infect Dis, 3(3): 285–292.
PMid:21887063 PMCid:PMC3162818
46. Ergonul, O., Tuncbilek, S., Baykam, N., Celikbas, A. and Dokuzoguz, B. (2006) Evaluation of serum levels of IL-6, IL-10, and TNF-alpha in patients with Crimean-Congo hemorrhagic fever. J Infect Dis, 193: 941 – 944.
47. Bodur, H., Akinci, E., Onguru, P., Carhan, A., Uyar, Y.,Tanrici, A.,Cataloluk, O. and Kubar, A. (2009) Detection of Crimean-Congo hemorrhagic fever virus genome in saliva and urine. International Journal of Infectious Diseases, 14: e247–e249.
48. Barut, S., Dincer, F., Sahin, I., Ozyurt, H., Akkus, M. and Erkorkmaz, U. (2010) Increased serum ferritin levels in patients with Crimean-Congo hemorrhagic fever: can it be a new severity criterion? International Journal of Infectious Diseases, 14: e50—e54.
49. Prajapati, D.S., Patel, K.M., Patel, R.K., Sen, D.J., Patel, J.S. and Garg, C.S. (2011)Crimean-congo hemorrhagic fever from tick-borne viral disease. Int J Compreh Pharm, 3(2). 1-6.
50. Mishra, A.C., Mehta, M., Mourya, D.T. and Gandhi, S. (2011)Crimean-Congo haemorrhagic fever in India. Lancet, 378: 372.
51. Nichol, S.T. (2001)Bunyaviruses. In: Knipe, D.M. andHowley, P.M. (Eds.), Fields Virology, vol. 1, fourth ed. Lippincott, Williams & Wilkins, Philadelphia, 1603–1633.
52. Shepherd, A.J., Swanepoel, R., Leman, P.A. and Sherpherd, S.P. (1986) Comparison of methods for isolation and titration of Crimean–Congo hemorrhagic fever virus. J Clin Microbiol, 24: 654–656.
PMid:3095367 PMCid:PMC268994
53. Donets, M.A., Rezapkin, G.V., Ivanov, A.P. and Tkachenko, E.A. (1982) Immunosorbent assays for diagnosis of Crimean–Congo haemorrhagic fever (CCHF). Am J Trop MedHyg, 31:156–162.
54. Drosten, C., Kummerer, B.M., Schmitz, H. and Gunther, S. (2003) Molecular diagnostics of viral hemorrhagic fevers. Antiviral Res, 57: 61–87.
55. Wölfel, R., Paweska, J.T., Petersen, N., Grobbelaar, A.A., Leman, P.A., Hewson, R., Georges-Courbot, M.C., Papa, A., Günther, S. and Drosten, C. (2007) Virus Detection and Monitoring of Viral Load in Crimean-Congo Hemorrhagic Fever Virus Patients.Emerg Infect Dis, 13(7):1097-1100.
PMid:18214191 PMCid:PMC2878241
56. Garrison, A.R., Alakbarova, S., Kulesh, D.A., Shezmukhamedova, D., Khodjaev, S., Endy, T.P. and Paragas, J. (2007) Development of a TaqMan–Minor Groove Binding Protein Assay for the Detection and Quantification of Crimean-Congo Hemorrhagic Fever Virus.Am J Trop MedHyg, 77(3): 514–520.
57. Izadi, S. and Salehi, M. (2009) Evaluation of the Efficacy of Ribavirin Therapy on Survival of Crimean-Congo Hemorrhagic Fever Patients. A Case-Control Study. Jpn J Infect Dis, 62: 11-15.
58. Watts, D.M., Ussery, M.A., Nash, D. and Peters, C.J. (1989) Inhibition of Crimean-Congo hemorrhagic fever viral infectivity yields in in-vitro by ribavirin. Am J Trop MedHyg, 41:581-585.
59. Bajpai, S. and Nadkar, M.Y. (2011) Crimean Congo Hemorrhagic Fever: Requires Vigilance and Not Panic JAPI, 59:164-167.
60. Papa, A., Papadimitriou, E. and Christova, I. (2011) The Bulgarian vaccine Crimean-Congo haemorrhagic fever virus strain. Scand J Infect Dis, 43:225–9.