Veterinary World


ISSN (Online): 2231-0916


 Editorial board

 Instructions for authors

 Reviewer guideline

 Open access policy




Open Access

Copyright: The authors. This article is an open access article licensed under the terms of the Creative Commons Attribution License ( which permits unrestricted use, distribution and reproduction in any medium, provided the work is properly cited.

Research (Published online: 27-01-2014)

9. Therapeutic efficacy of Brucella phage against Brucella abortus in mice model -

A. Prajapati, D. Ramchandran, H. Verma, M. Abbas and M. Rawat
Veterinary World, 7(1): 34-37


doi: 10.14202/vetworld.2014.34-37


1. Mantur, B.G. and Amarnath, S.K. (2008) Brucellosis in India – a review; J. Biosci., 33: 539–547.
2. Manish, K., Puran, C., Rajesh, C., Teena, R. and Sunil, K. (2013) Brucellosis: An updated review of the disease. Indian J Ani Sci., 83 (1): 3–16.
3. Garin-Bastuji, B and Blasco, J.M. (2008) Caprine and ovine brucellosis (excluding Brucella Ovis), 974-983. In Manual of Standards for diagnostic testes and vaccines. 2008. Office International des Epizooties, Paris, France.
4. Pappas, G., Nikolaos, A., Mile, B. and Epameinondas, T. (2005) N Engl J Med., 352: 2325-2336.
5. Ullah, R.W., Shirazi, J.H., Abubakar, M., Zahur, A.B., Latif, A. and Alam, T. (2013) Genetic diversity, zoonotic risk and "One Health" initiative of bovine brucellosis. Res. J. Vet. Pract., 1 (1): 5–9.
6. Renukaradhya, G.J., Isloor, S. and Rajasekhar, M. (2002) Epidemiology, zoonotic aspects, vaccination and control/eradication of brucellosis in India; Vet. Microbiol., 90: 183–195.
7. Hall, W.H. (1990) Modern chemotherapy for brucellosis in humans; Rev. Infect. Dis. 12 1060–1099.
8. World Health Organization (2006) Brucellosis in humans and animals. ISBN 92 4 154713 8.
9. Del, P., Solera, J. (2012) Systemic review and meta-analysis of randomized clinical trials in the treatment of human brucellosis. PLoS ONE 7: 32090.
10. Harper, D.R., Monk, A.B., Rees, C.D. and Barrow, P. and Hagens, S. (2010) Bacteriophage applications: where are we now? Appl Microbiol., 51: 363–369.
11. Abedon, S.T. and Loc-Carrillo, C. (2011) Pros and cons of phage therapy. Bacteriophage., 1: 111–114.
12. Connerton, P.L. and Connerton. I.F. (2005) Microbial treatments to reduce pathogens in poultry meat, 414– 427. In G. Mead (ed.), Food safety control in the poultry industry. Woodhead Publishing Ltd., Cambridge.
13. Cars, O., Högberg, L.D. and Murray, M. (2008) Meeting the challenge of antibiotic resistance. Br. Med. J., 337: 726-728.
14. Hyman, P. and Abedon, S.T. (2010) Bacteriophage host range and bacterial resistance. Adv Appl Microbiol., 70: 217–248.
15. Kumari, S., Harjai, K. and Chhibber, S. (2010) Topical treatment of Klebsiella pneumoniaeB5055 induced burn wound infection in mice using natural products. J Infect Dev Ctries., 4: 367–377.
16. Wright, A., Hawkins. C.H., Anggard, E.E. and Harper, D.R. (2009) A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic- resistant Pseudomonas aeruginosa; a preliminary report of efficacy. Clin Otolaryngol., 34: 349–357.
17. Hawkins, C., Harper, D., Burch, D., and Anggard, E. (2010) Topical treatment of Pseudomonas aeruginosa otitis of dogs with a bacteriophage mixture: a before/after clinical trial. Vet Microbiol., 146: 309–313.
18. Sulakvelidze, A. and Barrow., P. (2005) Phage therapy in animals and agribusiness, 335–380. In E. Kutter and A. Sulakvelidze (ed.), Bacteriophages: biology and applica- tions. CRC Press, Inc., Boca Raton, FL.
19. Huff, W.E., Huff, G.R., Rath, N.C., Balog, J.M. and Donoghue, A.M. (2003a) Evaluation of aerosol spray and intramuscular injection of bacteriophage to treat an Escherichia coli respiratory infection. Poult. Sci., 82:1108– 1112.
20. Huff, W.E., Huff, G.R., Rath, N.C., Balog, J.M. and Donoghue, A.M. (2003b) Bacteriophage treatment of a severe Escherichia coli respiratory infection in broiler chickens. Avian Dis., 47:1399–1405.
21. Chachra, D. (2011) Isolation and morphological characterization of a brucellaphage against Brucella abortus strain S19. World congress of biotechnology, Hyderabad India. doi:10.4172/2155-9538.10000S2
22. Adams, M.H. (1959) Bacteriophages. Interscience, Publishers, Inc., New York.
23. Chilamban, C., Rawat, M. and Somvanshi, R. (2004) Pre- clinical studies on therapy of Staphylococcus aureus mastitis by bacteriophage in mice model. 2004. Indian J Comp. Microbiol. Immunol. Infect. dis., 25: 98-103.
24. Gill, J.J., Svircev, A.M., Smith, R. and Castle, A.J. (2003) Bacteriophages of Erwinia amylovora. Appl Environ Microbiol., 69: 2133–2138.
25. Verma, H., Pramod, D., Abbas, M., Prajapati, A., Ramchandra, D. and Rawat, M. (2013) Isolation and partial characterization of lytic phage against Salmonella Abortusequi, Vet World., 6 (2): 72-75.
26. Miles, A. A. and. Misra., S. S (1938) The estimation of the bactericidal power of the blood. J. Hyg., 38 : 732-749.
27. María J.G., José M.B., Jean P.G., Ignacio M. and Edgardo M. (2002) What have we learned from brucellosis in the mouse model? Veterinary Research., 43:29. doi:10.1186/1297- 9716-43-29.
28. Bosseray, N. (1993) Control methods and thresholds of acceptability for anti-Brucella vaccines. Dev. Biol. Stand., 79: 121–128.
29. OIE: Bovine brucellosis. (2011) In Manual of Diagnostic Tests and Vaccines for Terrestrial Animals. World Organization for Animal Health, Paris, France., 1-35.
30. Snedecor, G.W. and Cochran, W.G. (1994) Statistical methods. 8th University Press Ames, Iowa, USA.
31. Chachra, D., Kaur, H., Chandra, M. and Saxena, H. (2012) Isolation, Electron Microscopy And Physicochemical Characterization Of A Brucella phage Against Brucella abortus Vaccine Strain S19. The Internet Journal of Microbiology., 10 (2) ; 79: 121-128.
32. Ostrovskaja, N.N. and Solov'ev, N.N. (1960) B. Mikrobiol. (Mosk.), No. 11, p. 4.
33. Ryan, E.M., Gorman, S.P., Donnelly, R.F., R.F and Gilmore, B.F. (2011) Recent advances in bacteriophage therapy: how delivery routes, formulation, concentration and timing influence the success of phage therapy. J. Pharm. Pharmacol., 63 (10): 1253–1264.
34. Parnas, J. (1960) Arch. Inst. Pasteur Tunis, 37: 215.
35. Pamas, J. and Burdzy, K. (1961a) Z. Immun. -Forsch., 121: 125.
36. Parnas, J. and Burdzy, K. (1961b) Z. Immun. -Forsch., 122: 453.
37. Drozevkina, M.S., Prostetova, N.P., and Haritonova, T.I. (1959) Trudy Rostovskogo Protivocumnogo Instituta., 14: 173.
38. Pophadze, M.S., Abagidze, T.G. and Karicasvili, L.N. (1959) Study of the clearing effect of Brucellaphage in cases of latent microbial infection., Second Scientific Conference on Bacteriophagy, Tbilisi., 18-21: 81.
39. Prostetova, N. P. (1959) Trudy Rostovskogo Protivoc' umnogo Instituta., 16: 117.
40. Oliveira A., Serenoa, R. and Azeredo, J. (2009) The in?uence of the mode of administration in the dissemination of three coliphages in chickens. J Poult Sci., 88: 728–733.
41. Stanford, K., McAllister, T.A., Niu, Y.D. (2010) Oral delivery systems for encapsulated bacteriophages targeted at Escherichia coli O157:H7 in feedlot cattle. J Food Prot., 73: 1304–1312.