Repair of segmental radial defect with autologous bone marrow aspirate and hydroxyapatite in rabbit radius: A clinical and radiographic evaluation

Vet World Vol.10 July-2017 Article-7

Research Article

Veterinary World, 10(7): 752-757

https://doi.org/10.14202/vetworld.2017.752-757

Kalbaza Ahmed Yassine^1,2, Benchohra Mokhtar¹, Hemida Houari¹, Amara Karim¹, and Melizi Mohamed²

1. Laboratory of Agro-Biotechnology and Nutrition in Semi-Arid Regions, Ibn Khaldoun University of Tiaret, Algeria.
2. Department of Veterinary Sciences, Institute of Agronomic and Veterinary Sciences, BATNA-1 University, Algeria.

Background and Aim: Finding an ideal bone substitute to treat large bone defects, delayed union and nonunions remain a challenge for orthopedic surgeons and researchers. Several studies have been conducted on bone regeneration; each has its own advantages and disadvantages. The aim of this study was to evaluate the effect of a combination of hydroxyapatite (HA) powder with autologous bone marrow (BM) aspirate on the repair of segmental radial defect in a rabbit model.

Materials and Methods: A total of 36 male and adult New Zealand rabbit with a mean weight of 2.25 kg were used in this study. Approximately, 5 mm defect was created in the mid-shaft of the radius to be filled with HA powder in the control group "HA" (n=18) and with a combination of HA powder and autologous BM aspirate in the test group "HA+BM" (n=18). Animals were observed daily for healing by inspection of the surgical site, and six rabbits of each group were sacrificed at 30, 60, and 90 post-operative days to perform a radiographic evaluation of defect site.

Results: Obtained results revealed a better and more rapid bone regeneration in the test group: Since the defect was rapidly and completely filled with mature bone tissue after 90 days.

Conclusion: Based on these findings, we could infer that adding a BM aspirate to HA is responsible of a better regeneration process leading to a complete filling of the defect. Keywords: autologous bone marrow aspirate, bone regeneration, hydroxyapatite, rabbit, radial defect.

Keywords: autologous bone marrow aspirate, bone regeneration, hydroxyapatite, rabbit, radial defect.

How to cite this article: Yassine KA, Mokhtar B, Houari H, Karim A, Mohamed M (2017) Repair of segmental radial defect with autologous bone marrow aspirate and hydroxyapatite in rabbit radius: A clinical and radiographic evaluation, Veterinary World, 10(7): 752-757.

Received: 20-02-2017 Accepted: 30-05-2017 Published online: 07-07-2017

Corresponding author: Kalbaza Ahmed Yassine E-mail: docahmedyacine@gmail.com

DOI: 10.14202/vetworld.2017.752-757

Copyright: Yassine, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.