Vet World   Vol.10   November-2017  Article-8

Production of aldosterone in cardiac tissues of healthy dogs and with dilated myocardiopathy

Background and Aim: Aldosterone is a hormone, belonging to the group of mineralocorticoids, mainly synthesized in the adrenal cortex, basically its function is to regulate blood pressure and sodium potassium levels in the body; high levels of this hormone have harmful effects in the organism and mainly in the heart in chronic form. Dilated cardiomyopathy is a progressive disease of heart muscle that is characterized by ventricular chamber enlargement and contractile dysfunction, is one of the most common cardiac conditions in dogs of medium and large breeds. The aim of the study was to determine and quantify if a dog's cardiac cells possess the capacity to synthesize aldosterone, as well as, the differences that appear between a healthy heart and with dilated myocardiopathy (DMC).

Materials and Methods: Cardiac tissues were used from six healthy dogs and six with DMC. Enzyme linked immunosorbent assay was performed to determine if the dog's heart cells synthesized this mineralocorticoid in a similar way to rat, rabbit, and human tissues, as well as quantitative differences between the healthy heart and DMC.

Results: In healthy dog hearts, aldosterone values were 62.5 pG for both the atria and right ventricle and 125 pG for the left ventricle. As for dog hearts' with DMC, results were 125 pG in all four cavities.

Conclusion: Both the healthy and DMC dog hearts produce aldosterone in all four cavities, observing that production increases in the atria and right ventricle of those hearts with DMC, as an intrinsic mechanism of cardiac remodeling. Keywords: cardiac insufficiency, dog heart, enzyme linked immunosorbent assay, mineralocorticoids.

Keywords: cardiac insufficiency, dog heart, enzyme linked immunosorbent assay, mineralocorticoids.

How to cite this article: Reynoso Palomar A, Mena Aguilar G, Cruz Garcia M, Pastelin Rojas C, Villa Mancera A (2017) Production of aldosterone in cardiac tissues of healthy dogs and with dilated myocardiopathy, Veterinary World, 10(11): 1329 1332.

Received: 05-08-2017  Accepted: 16-10-2017     Published online: 12-11-2017

Corresponding author: Abel Villa Mancera   E-mail: abel.villa@gmail.com

DOI: 10.14202/vetworld.2017.1329-1332

Copyright: Reynoso Palomar, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.