Effectiveness of platelet-rich fibrin matrix treated with silver nanoparticles in fracture healing in rabbit model

Vet World Vol.11 July-2018 Article-10

Research Article

Veterinary World, 11(7): 944-952

https://doi.org/10.14202/vetworld.2018.944-952

Serwa Ibrahim Salih¹, Nadia H. Al-Falahi¹, Ali H. Saliem², and Ahmed N. Abedsalih²

1. Department of Surgery and Obstetrics, University of Baghdad, Baghdad, Iraq.
2. Department of Physiology, Biochemistry and Pharmacology, University of Baghdad, Baghdad, Iraq.

Background and Aim: The current study was conducted to evaluate the effect of platelet-rich fibrin matrix (PRFM) treated with silver nanoparticles (AgNPs) on enhancing the healing of the experimentally induced bone gap in a rabbit model.

Materials and Methods: Twenty healthy male local rabbits aged between 6 and 8 months, their weights between 1.5 and 2 kg were used in this study and divided randomly into four equal groups, under general anesthesia (1 cm), bone gap was induced in the tibia bone to create a critical bone defect and leave it without any treatment in the first group (control group). While in the second group the bone gap was filled with PRFM; in the third group, the gap was filled with 0.3 ml AgNPs; and in the fourth group, the gap was filled with PRFM treated with AgNPs.

Results: There was no infection at the operation site in all experimental animals, and the radiograph images showed periosteal and endosteal reaction; the gaps were bridged faster in the fourth group as compared with the other groups. The histological examination showed lamellar bone with haversian canal completely filled the fracture gap and contact with old bone in the fourth group as compared to other groups.

Conclusion: Using a combination of PRFM and single nucleotide polymorphisms together gave better acceleration in the bone healing process than using each one of them separately. Keywords: bone gap, healing, platelet-rich fibrin matrix, silver nanoparticles.

Keywords: bone gap, healing, platelet-rich fibrin matrix, silver nanoparticles.

How to cite this article: Salih SI, Al-Falahi NH, Saliem AH, Abedsalih AN (2018) Effectiveness of platelet-rich fibrin matrix treated with silver nanoparticles in fracture healing in rabbit model, Veterinary World, 11(7): 944-952.

Received: 30-03-2018 Accepted: 04-06-2018 Published online: 16-07-2018

Corresponding author: Ali H. Saliem E-mail: alisaliem977@gmail.com

DOI: 10.14202/vetworld.2018.944-952

Copyright: Salih, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.