Vet World Vol.11 May-2018 Article-9
Review Article
Veterinary World, 11(5): 627-635
https://doi.org/10.14202/vetworld.2018.627-635
The crucial roles of inflammatory mediators in inflammation: A review
2. Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Malaysia.
3. Department of Community Health, College of Health and Medical Techniques, Al-Furat Al-Awsat Technical University, Iraq.
4. Department of Veterinary Preclinical Sciences, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Malaysia.
5. Department of Veterinary Laboratory Diagnostics, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Malaysia.
6. Department of Chemistry, Faculty of Sains, Universiti Putra Malaysia, Malaysia.
Background and Aim: The inflammatory response is a crucial aspect of the tissues' responses to deleterious inflammogens. This complex response involves leukocytes cells such as macrophages, neutrophils, and lymphocytes, also known as inflammatory cells. In response to the inflammatory process, these cells release specialized substances which include vasoactive amines and peptides, eicosanoids, proinflammatory cytokines, and acute-phase proteins, which mediate the inflammatory process by preventing further tissue damage and ultimately resulting in healing and restoration of tissue function. This review discusses the role of the inflammatory cells as well as their by-products in the mediation of inflammatory process. A brief insight into the role of natural anti-inflammatory agents is also discussed. The significance of this study is to explore further and understand the potential mechanism of inflammatory processes to take full advantage of vast and advanced anti-inflammatory therapies. This review aimed to reemphasize the importance on the knowledge of inflammatory processes with the addition of newest and current issues pertaining to this phenomenon.
Keywords: chemokines, cytokines, inflammatory mediators, inflammatory response.
How to cite this article: Abdulkhaleq LA, Assi MA, Abdullah R, Zamri-Saad M, Taufiq Yap YH, Hezmee MNM (2018) The crucial roles of inflammatory mediators in inflammation: A review, Veterinary World, 11(5): 627-635.
Received: 24-01-2018 Accepted: 10-04-2018 Published online: 15-05-2018
Corresponding author: Rasedee Abdullah E-mail: rasedee@upm.edu.my
DOI: 10.14202/vetworld.2018.627-635
Copyright: Abdulkhaleq, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.