Vet World Vol.12 April-2019 Article-9
Research Article
Veterinary World, 12(4): 542-550
https://doi.org/10.14202/vetworld.2019.542-550
Effect of exogenous progesterone treatment on ovarian steroid hormones and oxidant and antioxidant biomarkers during peak and low breeding seasons in dromedary she-camel
2. Department of Theriogenology, Faculty of Veterinary Medicine, Aswan University, Egypt.
3. Department of Animal Health, Desert Research Center, Cairo, Egypt.
Background and Aim: This study evaluated the effect of exogenous P4 hormone using CIDR for 7 days on blood concentrations of steroid hormones and oxidative status of dromedary she-camels during peak and low breeding seasons.
Materials and Methods: The present work was conducted on ten dark dromedary she-camels which were synchronized using a controlled internal drug release (CIDR) for 7 days as a reproductive management tool during peak breeding (November-April) and low breeding season (May-October). The blood samples were collected each other day from CIDR insertion until the end of experiment 5 days after the removal of CIDR. Camels were examined for P4, estradiol (E2), and testosterone (T) as well as malondialdehyde (MDA) as indicator of lipid peroxidation and nitric oxide, superoxide dismutase (SOD), and glutathione-S-transferase as antioxidant markers.
Results: Results revealed that P4 was higher during peak breeding season than low breeding season. While the levels of P4 increased during CIDR insertion and declined at CIDR removal and thereafter during breeding season, its concentrations declined after CIDR application during the non-breeding season. On the other hand, blood E2 and testosterone levels decreased after CIDR insertion in both high and low breeding seasons with higher serum E2 concentrations during the peak than the low breeding season. MDA concentrations and SOD activities were significantly (p<0.05) high on day 3 after CIDR insertion during the breeding and non-breeding seasons. During both the seasons, GSH levels decreased after CIDR removal in camels. However, MDA was lower during non-breeding season than high breeding season with no seasonal effect on SOD activity.
Conclusion: Exogenous P4 treatment through CIDR in dromedary camels could be more efficient during breeding season than non-breeding season, and effects on circulating oxidant/antioxidant biomarkers and their return to normal levels might refer to the adaptation of camels to CIDR by modulating their oxidant and antioxidant levels. Keywords: breeding season, camel, controlled internal drug release, ovarian hormones, oxidant/antioxidant biomarkers.
Keywords: breeding season, camel, controlled internal drug release, ovarian hormones, oxidant/antioxidant biomarkers.
How to cite this article: El-Maaty AMA, Mohamed RH, Hozyen HF, El-Kattan AM, Mahmoud MA, Ali AH (2019) Effect of exogenous progesterone treatment on ovarian steroid hormones and oxidant and antioxidant biomarkers during peak and low breeding seasons in dromedary she-camel, Veterinary World, 12(4): 542-550.
Received: 11-11-2018 Accepted: 26-02-2019 Published online: 17-04-2019
Corresponding author: Heba F. Hozyen E-mail: drheba23@yahoo.com
DOI: 10.14202/vetworld.2019.542-550
Copyright: El-Maaty AMA, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.