Vet World   Vol.12   February-2019  Article-11

Alteration in behavior of rat after chronic exposure to acetamiprid

Background and Aim: Acetamiprid is a chemical of neonicotinoid group which binds with nicotinic acetylcholine receptor (nAChR) and alters the brain function. The present study was taken up to enlight the understanding of nociception behavior in Sprague Dawley (SD) rat after multiple exposures to acetamiprid.

Materials and Methods: For experiment purpose, a total of 48 SD rats were divided into four dose groups having 12 animals each. Group I was control group received only distilled water. Group II, Group III, and Group IV were treated with acetamiprid at a dose rate of 5, 20, and 40 mg/kg body weight, respectively. Rats were tested in induced pain by formalin injection and tail flick test.

Results: The flinch counts in formalin-induced pain in acetamiprid-treated rat were reduced in a dose-dependent manner, whereas, in tail flick test, no such altered pain behavior was observed in treated group compared to control animals.

Conclusion: Acetamiprid alters the centralized nociception through nAChR but could not trigger the associated signal to inhibit the nociception peripherally. Keywords: acetamiprid, formalin, pain, tail flick.

Keywords: acetamiprid, formalin, pain, tail flick.

How to cite this article: Mondal S, Pradhan S, Mukhopadhayay SK (2019) Alteration in behavior of rat after chronic exposure to acetamiprid, Veterinary World, 12(2): 254-257.

Received: 22-08-2018  Accepted: 28-12-2018     Published online: 13-02-2019

Corresponding author: Samiran Mondal   E-mail: vetsamiran@gmail.com

DOI: 10.14202/vetworld.2019.254-257

Copyright: Mondal, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.