Vet World Vol.15 June-2022 Article-2
Research Article
Veterinary World, 15(6): 1408-1412
https://doi.org/10.14202/vetworld.2022.1408-1412
Analysis of insulin resistance using the non-linear homeostatic model assessment index in overweight canines
2. Institute of Nutrition and Food Technology INTA, University of Chile, Santiago, Chile.
Background and Aim: Diabetes mellitus is a carbohydrate metabolism disorder produced mainly by a deficit in insulin production or insulin resistance. The homeostatic model assessment (HOMA) is a broad method for estimating insulin resistance and β-cell function. This study aimed to evaluate the stages of insulin resistance using non-linear HOMA index analysis in normoglycemic normal weight and obese canines.
Materials and Methods: Insulin resistance was evaluated using the mathematical HOMA non-linear model in canines with different body and glycemic conditions. Forty canines were studied, including 20 normoglycemic normal weight canines and 20 normoglycemic obese canines. Chi-square statistical test was applied, in which the body condition and HOMA non-linear index were evaluated. The Spearman correlation test was conducted to evaluate the glycemic and insulin variables in both types of canines.
Results: The Spearman correlation presented a correlation between increased blood glucose levels and insulin in obese canines, with a correlation of 0.79, while no significant changes in insulin were found in normal weight canines with different blood glucose levels, with a correlation of –0.11. The analysis of the non-linear HOMA index showed significant differences between non-linear HOMA insulin resistance in normal weight and obese canines, with a Chi-square statistic of 16.9424 and p = 0.000039. Canine with increased HOMA 2 showed higher levels of insulin with increasing blood glucose compared to those with normal HOMA 2.
Conclusion: The HOMA 2 is a marker for evaluating increased insulin resistance in obese dogs and can be used to determine patients at risk for glycemic alterations. Keywords: diabetes, glycemia, insulin resistance, overweight.
Keywords: diabetes, glycemia, insulin resistance, overweight.
How to cite this article: Gonzlez-Villar F, Pérez-Bravo F (2022) Analysis of insulin resistance using the non-linear homeostatic model assessment index in overweight canines, Veterinary World, 15(6): 1408-1412.
Received: 26-01-2022 Accepted: 22-04-2022 Published online: 08-06-2022
Corresponding author: Francisco Pérez-Bravo E-mail: fperez@inta.uchile.cl
DOI: 10.14202/vetworld.2022.1408-1412
Copyright: Gonzlez-Villar and Pérez-Bravo, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.