Research Article | 13 Nov 2024

Genome-wide association study of genetic markers of coat color patterns in Sumatran native cattle

Hartati Hartati1, Widya Pintaka Bayu Putra2, Eko Handiwirawan1, Erpan Ramon1, Jhon Firison1, Zubir Zubir1, Nandari Dyah Suretno3, Mariyono Mariyono1, Yenni Yusriani1, Dewi Khosiya Robba1, Alfian Destomo1, Tika Anggraeni4, Pajri Anwar5, Sulistiyoningtiyas Irmawanti1, Aprisal Aprisal6, Simon Elieser1, and Dian Kurniawati7Show more
VETERINARY WORLD | pg no. 2537-2543 | Vol. 17, Issue 11 | DOI: 10.14202/vetworld.2024.2537-2543
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Abstract

          
Background and Aim: Coat color is a phenotypic trait that is affected by many functional genes. In addition, coat color is an important characteristic of breeds in livestock. This study aimed to determine functional genes for coat color patterns in Sumatran native cattle in Indonesia using a genome-wide association study method. 
Materials and Methods: A bovine single nucleotide polymorphism (SNP) 50K BeadChip was used for the investigation. A total of 46 Sumatran native cattle of three colors as follows: Brown (36 animals), white (9 animals), and black (1 animal), were used as experimental animals. 
Results: Results showed that the SNP markers ARS-BFGL-NGS-75486 (p = 2.46 × 10<sup>-7</sup>) and BTB-01992588 (p = 1.06 × 10<sup>-5</sup>) were selected as two genetic markers for coat color variation in animals under study, which were located at the cytoplasmic FMR1-interacting protein 2 (CYFIP2) gene at BTA7 and small G protein signaling modulator 1(SGSM1) genes at BTA17, respectively. The polymorphic informative content values of both SNP markers were 0.33 (ARS-BFGL-NGS-75486) and 0.13 (BTB-01992588). In this study, a genetic marker for coat color patterns in Sumatran native cattle was obtained based on the haplotypes of both SNP markers. 
Conclusion: It can be concluded that CYFIP2 and SGSM1 are two coloration genes that affect the phenotype characteristics of Sumatran native cattle. 
          
Keywords: cattle, coat color, functional gene, genome-wide association study, Sumatra.