Open Access
Research (Published online: 09-04-2021)
5. Dietary polyvinyl alcohol and alginate nanofibers ameliorate hyperglycemia by reducing insulin and glucose-metabolizing enzyme levels in rats with streptozotocin-induced diabetes
Muhammad Suryadiningrat, Devia Yoanita Kurniawati, Agung Mujiburrahman and Muhammad Thohawi Elziyad Purnama
Veterinary World, 14(4): 847-853

Muhammad Suryadiningrat: Department of Veterinary Science, Division of Veterinary Anatomy, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya 60115, Indonesia.
Devia Yoanita Kurniawati: Department of Veterinary Science, Division of Veterinary Anatomy, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya 60115, Indonesia.
Agung Mujiburrahman: Department of Veterinary Science, Division of Veterinary Anatomy, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya 60115, Indonesia.
Muhammad Thohawi Elziyad Purnama: Department of Veterinary Science, Division of Veterinary Anatomy, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya 60115, Indonesia.

doi: www.doi.org/10.14202/vetworld.2021.847-853

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Article history: Received: 04-11-2020, Accepted: 16-02-2021, Published online: 09-04-2021

Corresponding author: Muhammad Thohawi Elziyad Purnama

E-mail: thohawi@fkh.unair.ac.id

Citation: Suryadiningrat M, Kurniawati DY, Mujiburrahman A, Purnama MTE (2021) Dietary polyvinyl alcohol and alginate nanofibers ameliorate hyperglycemia by reducing insulin and glucose-metabolizing enzyme levels in rats with streptozotocin-induced diabetes, Veterinary World, 14(4): 847-853.
Abstract

Background and Aim: Dietary management and antidiabetic drugs are used as therapies for diabetic patients worldwide. Alginate nanofibers were developed as a digestible food product that provides sufficient calories. This study aimed to evaluate the effect of polyvinyl alcohol (PVA) and alginate nanofibers on weight gain, blood glucose levels, and insulin and other serum parameters in diabetic rats.

Materials and Methods: A total of 24 male Wistar rats were divided into six groups: (C–) Control group, (C+) diabetic rats, (T1) diabetic rats + fasting treatment for 12 h, (T2) diabetic rats + nanofibers ad libitum, (T3) diabetic rats + metformin + nanofibers ad libitum, and (T4) diabetic rats + metformin. All groups were treated for 21 days. Weight gain was evaluated by comparing initial and final weights. Blood glucose levels were evaluated weekly. Serum parameters were also evaluated at the end of the study. All variables were analyzed statistically using analysis of variance followed by Tukey's post hoc test (p<0.05).

Results: The T2, T3, and T4 groups showed a significant increase in weight compared to that of the C+ and T1 groups. The T3 group had the lowest blood glucose level of all groups at the end of the study. In the serum evaluation, the T2 and T3 groups showed a significant decrease compared to the C+ group for the following variables: Alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT), creatinine, tumor necrosis factor-alpha (TNF-α), and interleukin-1β (IL-1β). In contrast, the T2 group showed a significant decrease compared to the T3 group for aspartate aminotransferase and insulin levels.

Conclusion: PVA and alginate nanofibers can modulate obesity, reduce blood glucose levels, and reduce serum levels of insulin, ALT, ALP, GGT, creatinine, TNF-α, and IL-1β in diabetic rats.

Keywords: alginate nanofibers, blood glucose, diabetes, insulin, serum.