Open Access
Research (Published online: 24-10-2021)
19. Influence of acetate containing fluid versus lactate containing fluid on acid-base status, electrolyte level, and blood lactate level in dehydrated dogs
Annika Heitland, Ute Klein-Richers, Katrin Hartmann and René Dörfelt
Veterinary World, 14(10): 2714-2718

Annika Heitland: AniCura Tierklinik Haar GmbH, Haar, Germany.
Ute Klein-Richers: Centre of Clinical Veterinary Medicine , Faculty of Veterinary Medicine, Clinic of Small Animal Medicine, Ludwig-Maximilians-University Munich, Munich, Germany.
Katrin Hartmann: Centre of Clinical Veterinary Medicine , Faculty of Veterinary Medicine, Clinic of Small Animal Medicine, Ludwig-Maximilians-University Munich, Munich, Germany.
René Dörfelt: Centre of Clinical Veterinary Medicine , Faculty of Veterinary Medicine, Clinic of Small Animal Medicine, Ludwig-Maximilians-University Munich, Munich, Germany.

doi: www.doi.org/10.14202/vetworld.2021.2714-2718

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Article history: Received: 29-06-2021, Accepted: 13-09-2021, Published online: 24-10-2021

Corresponding author: René Dörfelt

E-mail: r.doerfelt@medizinische-kleintierklinik.de

Citation: Heitland A, Klein-Richers U, Hartmann K, Dörfelt R (2021) Influence of acetate containing fluid versus lactate containing fluid on acid-base status, electrolyte level, and blood lactate level in dehydrated dogs Veterinary World, 14(10): 2714-2718.
Abstract

Background and Aim: Acetate or lactate buffered, balanced isotonic rehydration fluids are commonly used for fluid therapy in dogs and may influence acid-base and electrolyte status. This study aimed to assess acid-base status, electrolyte levels, and lactate levels in dehydrated dogs after receiving acetate or lactate-containing intravenous rehydration fluids.

Materials and Methods: In this prospective, randomized study, 90 dehydrated dogs were included and randomized to receive acetate [Sterofundin® ISO B. Braun Vet Care (STERO), Germany) or lactate (Ringer-Lactat-Lösung nach Hartmann B. Braun Vet Care (RL), Germany] containing intravenous fluids for rehydration. The exclusion criteria were as follows: Age <6 months, liver failure, congestive heart failure, and extreme electrolyte deviation. Physical examination, venous blood gas, and lactate levels were analyzed before and after rehydration. The two groups were compared using t-test and Chi-square test. The significance level was set at p≤0.05.

Results: Post-rehydration heart rate decreased in the STERO group (p<0.001) but not in the RL group (p=0.090). Lactate levels decreased in both groups STERO (p<0.001) and in group RL (p=0.014). Sodium and chloride levels increased during rehydration in group STERO (p<0.001; p<0.001) and group RL (p=0.002; p<0.001). There was a larger decrease in lactate levels in group STERO compared to group RL (p=0.047).

Conclusion: Both solutions led to a mild increase in sodium and chloride levels and decreased lactate levels. The acetate-containing solution had an inferior effect on the decrease in lactate level.

Keywords: acid-base disorders, crystalloid solutions, fluid therapy, hyperlactatemia, metabolic acidosis, rehydration.