Zebrafish as an experimental model for the simulation of neurological and craniofacial disorders

Vet World Vol.15 January-2022 Article-4

Review Article

Veterinary World, 15(1): 22-29

https://doi.org/10.14202/vetworld.2022.22-29

Ashwin Rohan Rai¹, Teresa Joy², K. S. Rashmi³, Rajalakshmi Rai¹, N. A. Vinodini³, and P. J. Jiji¹

1. Department of Anatomy, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.
2. Department of Anatomy, American University of Antigua College of Medicine, University Park, Coolidge, St. John's, Antigua.
3. Department of Physiology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Background and Aim: Zebrafish have gained momentum as a leading experimental model in recent years. At present, the zebrafish vertebrate model is increasingly used due to its multifactorial similarities to humans that include genetic, organ, and cellular factors. With the emergence of novel research techniques that are very expensive, it is necessary to develop affordable and valid experimental models. This review aimed to highlight some of the most important similarities between zebrafish and humans by emphasizing the relevance of the first in simulating neurological disorders and craniofacial deformity.

Keywords: craniofacial deformity, experimental model, neurological disorders, zebrafish.

How to cite this article: Rai AR, Joy T, Rashmi KS, Rai R, Vinodini NA, Jiji PJ (2022) Zebrafish as an Experimental Model for the Simulation of Neurological and Craniofacial Disorders, Veterinary World, 15(1): 22-29.

Received: 02-08-2021 Accepted: 30-11-2021 Published online: 11-01-2022

Corresponding author: Teresa Joy E-mail: tjoy@auamed.net

DOI: 10.14202/vetworld.2022.22-29

Copyright: Rai, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.