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Open Access
Copyright: The authors. This article is an open access
article licensed under the terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/2.0) which permits unrestricted use,
distribution and reproduction in any medium, provided the work is properly
cited.
Research
5.
Acute toxicity studies of polyherbal formulation (Methiorep
Premix) -
S. Rajurker, D S Rekhe, S Maini, K Ravikanth
Vet World. 2009; 2(2): 58-59
doi: 10.5455/vetworld.2009.58-59
Abstract
An
experimental study with the objective to evaluate the acute
toxicity of polyherbal formulation Methiorep Premix (supplied by
Ayurvet Ltd., Baddi, India), was done as per OECD guidelines
423. Methiorep is a scientifically developed combination of
herbs that contains herbal ingredients rich in Methionine in
free form as well as conjugated form. The study was done on 3
males and 3 female Wistar Albino rats, which were, administered
an initial dose of 500-mg/kg-body weight followed by 2000 mg/kg
& 5000 mg/kg body weight. The animals were observed for signs of
convulsions, tremors, circling, depression, excitement and
mortality. Body weight was recorded at 0,7th and
14th day
and plasma total protein, albumin; AST and ALT were measured to
evaluate the toxicity of the preparation. No abnormal sign of
symptoms were observed in any of the animal fed with Methiorep
Premix at the dose rate of 500-mg/kg body weights, 2000 mg/kg
body weight & 5000mg/kgbody weight. No mortality was observed in
any of the animals indicating its safety.
Keywords:
Toxicity, Polyherbal, Broiler, Premix, Wistar Albino Rat,
Animal.
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