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Research
6.
Haemato-biochemical
alterations induced by lead acetate toxicity in
wistar rats -
S.G.
Suradkar, D.J.Ghodasara, Priti Vihol, Jatin Patel,
Vikas Jaiswal and K.S. Prajapati
Veterinary
World 2(11):429-431
Abstract
An
experiment was conducted to study the haemato-biochemical
alterations induced by lead acetate toxicity in 48
Wistar rats of either sex, divided uniformly into
four different groups. The rats of group I received
only deionised water as control while, group II, III
and IV were given lead acetate @ 1 PPM, 100 PPM and
1000 PPM, in drinking deionised water respectively
for 28 days. In group III and IV dose dependant
significant (P<0.05) reductions in TEC, Hb, PCV and
TLC were observed. No significant change was
observed in neutrophil, eosinophil, basophil and
monocyte count in any treatment groups, whereas the
lymphocyte count decreased significantly (P<0.05) in
group III and IV. A dose dependant significant
(P<0.05) increase in AST, ALP, AKP, GGT, BUN and
creatinine was experiential while TP and albumin
levels were decreased in group III and IV.
Keywords: Biochemical, Haematology, Lead
acetate, Wistar rats, Toxicity.
