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Research
10.
Patho-morphological changes in tissues of wistar rats by exposure of
lead acetate -
S. G. Suradkar, P. D. Vihol, J. H. Patel, D. J. Ghodasara,
B. P. Joshi and K. S. Prajapati
Veterinary
World 3(2):
82-84
Abstract
The study was carried out to evaluate
pathomorphological changes induced by lead acetate
toxicity in 48 wistar rats which were uniformly
divided into four different groups. The group I
received only deionised water as control while,
group II, III and IV rats were given Lead acetate @
1, 100 and 1000 PPM respectively in drinking water
for 28 days. After 28 days of treatment with lead
acetate, rats were sacrificed. The lesions were
characterized by degeneration, necrosis, cellular
and vascular changes. The main target organs
affected were kidney, liver and testes. The overall
lesions gave impression that lead is hepatotoxic as
well as nephrotoxic in nature. The intensity and
distribution of such lesions were found more severe
in rats of group IV, followed by rats of group III.
Key words: Pathomorphological effect, Lead
acetate, Wistar rats
