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Preparation and evaluation of veterinary 20% injectable solution
of tylosin -
Fouad K. Mohammad, Muzahim Y. Al-Attar, Faris T. Abachi , Ashraf
S. Alias, Thiab A. Al-Sawah and Talib A. Al-Talib
Vet World. 2010; 3(1): 5-7
A veterinary injectable aqueous
solution of the antibiotic tylosin at
a concentration of 20% was prepared under aseptic conditions in
dark glass bottles each containing 100 ml. The preparation was
intended for animal use only. It contained 200 g tylosin tartrate,
500 ml propylene glycol, benzyl alcohol 40 ml as a preservative
and water for injection up to 1000 ml. The preparation was clear
yellow viscous aqueous solution free from undesired particles.
The preparation complied with the requirements for injectable solutions.
It was active in vitro
against E. coli (JM83). The preparation of 20%tylosin solution
was safe under field conditions in treating sheep
and cattle suffering from pneumonia at the dose rate of 1 ml/20
kg body weight, intramuscularly/ day for 3 successive days. In
conclusion, we presented the know-how of a veterinary
formulation of injectable solution
of 20% tylosin for
clinical use in ruminants.
Key words: Tylosin,
Veterinary preparation, Pneumonia, Injectable solution.