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Research
5.
Radiological evaluation of the effects of varied
doses of celecoxib on fracture healing in dogs -
Aihanuwa Uwagie-Ero Edwin, Chukwujekwu Kene Rapheal
Vet World. 2011; 4(2): 75-76
doi:
10.5455/vetworld.2011.75-76
Abstract
To determine if Cyclooxygenase -2 (COX-2) functions
in fracture healing, 10 dogs were treated with
COX-2-selective nonsteroidal anti-inflammatory drugs
(Celecoxib) to reduce and stop COX-2-dependent
prostaglandin production. Radiographic testing
evaluation determined that fracture healing was not
affected in dogs treated with a low dose of
COX-2-selective NSAIDs (celecoxib) and delayed union
was observed in dogs treated with a high dose of
COX-2-selective NSAIDs (celecoxib). Celecoxib dose
of 5 mg/kg/day did not affect fracture callus formed
in the study group and did not cause a significant
increase in the proportion of delayed unions,
however, at a dose of 10 mg/kg/day it reduced the
rate of fracture callus formation and significantly
increased the proportion of delayed unions for dogs
in the group.
Key words: Analgesia, Celecoxib,
Cyclooxygenase, dog, Fracture healing.
