Veterinary World


ISSN (Online): 2231-0916


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Copyright: The authors. This article is an open access article licensed under the terms of the Creative Commons Attribution License ( which permits unrestricted use, distribution and reproduction in any medium, provided the work is properly cited.

doi: 10.5455/vetworld.2011.234-240

Germ cells are endowed with unique properties like the ability to undergo meiosis and differentiate into gametes in order to perpetuate the genetic material. Spermatogonial stem cells (SSC) are considered as the best suited undifferentiated germ cells and are being consistently studied to reveal the basic physiology, genomics and transcriptomics of those cells. SSC provide an excellent model system to understand the differentiation, development and functioning of gonads and further use of these cells in transplantation-cell based therapies. In the present article, basic aspects of spermatogonial multiplication, regulation of stem cell renewal and differentiation would be discussed.

Keywords: Spermatogonial stem cells, spermatogenesis, testis, self-renewal.