Veterinary World


ISSN (Online): 2231-0916


 Editorial board

 Instructions for authors

 Reviewer guideline

 Open access policy





Open Access

Copyright: The authors. This article is an open access article licensed under the terms of the Creative Commons Attribution License ( which permits unrestricted use, distribution and reproduction in any medium, provided the work is properly cited.

Research (Published online : 03-09-2013)

21. Antioxidative effect of yak milk caseinates hydrolyzed with three different proteases - Santosh Kumar, Vikrant Singh Chouhan, Ashwani Sanghi and Udai Vir Singh Teotia
Veterinary World, 6(10): 799-802


1. FitzGerald, R.J., Murray, B.A. and Walsh, D.J. (2004) Hypotensive peptides from milk proteins. J Nutr., 134: 980S–988S.
2. Haque, E. and Chand, R. (2008) Antihypertensive and antimicrobial bioactive peptides from milk proteins. Eur Food Res Technol., 227: 7–15.
3. Sarmadi, B.H. and Ismail, A. (2008) Antioxidative peptides from food proteins: a review. Peptides., 31: 1949–1956.
4. Silva, S.V. and Malcata, F.X. (2005) Casein as source of bioactive peptides. Int Dairy J., 15: 1–15.
5. Korhonen, H. (2009) Milk-derived bioactive peptides: from science to applications. J Func Foods., 1: 177–187.
6. Korhonen, H., and Pihlanto, A. (2006) Bioactive peptides: Production and functionality. Int Dairy J., 16: 945–960.
7. Phelan, M., Aherne, A., FitzGerald, R.J. and O'Brien, N.M. (2009) Casein-derived bioactive peptides: biological effects, industrial uses, safety aspects and regulatory status. Int Dairy J., 19: 643–654.
8. Minervini, F., Algaron, F., Rizzello, C.G., Fox, P.F., Monnet, V. and Gobbetti, M. (2003) Angiotensin I-converting- enzyme-inhibitory and antibacterial peptides from Lactobacillus helveticus PR4 proteinase-hydrolyzed caseins of milk from six species. Appl Environ Microbiol., 69: 5297–5305.
PMid:12957917 PMCid:PMC194939
9. Benkerroum, N. (2010) Antimicrobial peptides generated from milk proteins: a survey and prospects for application in the food industry. A review. Int J Dairy Technol., 63: 320– 338.
10. Lowry. O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. (1951) Protein measurement with folin-phenol reagent. J. Biol. Chemistry., 193: 265-275.
11. Abubakar, A., Saito, T., Kitazawa, H., Kawai, Y. and Itoh, T. (1998) Structural analysis of new antihypertensive peptide by proteinase K digestion. J.Dairy Sci., 81:3131-3138.
12. Pihlanto-Leppala, A., Koskinen, P., Piilola, K., Tupasela, T. and Korhonen, H. (2000) Angiotensin -1 converting enzyme inhibitory properties of whey protein digest: Concentration and characterization of active peptide. J.Dairy Res., 67:53-64.
13. Hull, M.E. (1947) Studies on Milk Proteins. II. Colorimetric Determination of the Partial Hydrolysis of the Proteins in Milk. J. Diary Sci., 30 (11): 881-884.
14. Brand-Williams, W., Cuvelier, M. E. and Berset, C. (1995) Use of free radical method to evaluate antioxidant activity. LWT Food Sci Technol., 28: 25–30.
15. Hernandez-Ledesma, B., Recio, I., Ramos, M. and Amigo, L. (2002) Preparation of ovine and caprine ß-lactoglobulin hydrolysates with ACE inhibitory activity: Identification of active peptides from caprine ß-lactoglobulin hydrolyzed with thermolysin. Int. Dairy J., 12: 805-812.
16. Sarmadi, B.H. and Ismail, A. (2010) Antioxidative peptides from food proteins: a review. Peptides., 31: 1949–1956.
17. Hogan, S., Zhang, L., Li, J., Wang, H. and Zhou, K. (2009) Development of antioxidant rich peptides from milk protein by microbial proteases and analysis of their effects on lipid peroxidation in cooked beef. Food Chem., 117: 438–443.
18. Zhang, L., Li, J. and Zhou, K. (2010) Chelating and radical scavenging activities of soy protein hydrolysates prepared from microbial proteases and their effect on meat lipid peroxidation. Bioresour Technol., 101: 2084–2089.
19. Grosclaude, F., Mahé, M.F. and Mercier, J.C. (1974) Comparaison du polymorphisme génétique des lactopro- téines du zébu et des bovins. Annales de Génétique et de Sélection Animale, 6: 305-329.
PMid:22896451 PMCid:PMC2725079
20. Grosclaude, F., Mahé, M.F., Mercier, J.C., Bonnemaire, J. and Teissier, J.H. (1976b) Polymorphisme des lactoprotéines de bovinés népalais. II. Polymorphisme des caséines as- mineures; le locus as2-Cn est-il lié aux loci as1-Cn, ß-Cn et - ?Cn? Annales de Génétique et de Sélection Animale 8(4): 481–491.
PMid:22896506 PMCid:PMC2724574
21. Sulimova, G.E., Badagueva, IuN., Udina, I.G. (1996) Polymorphism of the kappa-casein gene in populations of the subfamily Bovinae. Genetika. 32 (11): 1576-1582.
22. Mao, X.Y., Cheng, X., Wang, X. and Wu, S.J. (2011) Free- radical-scavenging and anti-inflammatory effect of yak milk casein before and after enzymatic hydrolysis. Food Chem., 126: 484–490.
23. Chang, C.Y., Wu, K.C. and Chiang, S.H. (2007) Antioxidant properties and protein compositions of porcine haemoglobin hydrolysates. Food Chem., 100: 1537–1543.
24. Rival, S.G., Boeriu, C.G. and Wichers, H.J. (2001) Caseins and casein hydrolysates. 2. Antioxidative properties and relevance to lipoxygenase inhibition. J Agric Food Chem., 49: 295–302.
25. Saiga, A., Tanabe, S. and Nishimiura, T. (2003) Antioxidant activity of peptides obtained from porcinemyofibrillar proteins by protease treatment. J Agric Food Chem. 51:3661–3667.