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Review (Published online : 04-07-2013)
10. Does contemporary canine diet cause cancer? ; A review -
Joseph B Gentzel

Vet World. 2013; 6(9): 632-639


1. Murua Escobar, H., Soller, J., Sterenczak, K., Sperveslage, J., Schlueter, C., Burchardt, B., Eberle, N., Fork, M., Nimzyk, R., Winkler, S., Nolte, I. and Bullerdiek, J. (2006) Cloning and characterization of the canine receptor for advanced glycation end products. Gene. 369:45-52.


2. Sterenczak, K., Willenbrock, S., Barann, M., Klemke, M., Soller, J., Eberle, N., Nolte, I., bullerdiek, J. and Murua Escobar, H. (2009) Cloning, characterisation, and comparative quantitative expression analyses of receptor for advanced glycation end products (RAGE) transcript forms. Gene. 434(1-2):35-42.


3. De Marzo, A., Coffey, D. and Nelson, W. (1999) New concepts in tissue specificity for prostate cancer and benigh prostatic hyperplasia. Urology. 53(Suppl 3a):29-39.


4. Miya, K., Misumi, K., Miyoshi, N., Aria, K., Fujik, M., Kubota, C., Salamoto, H. (2005)Interpreting gelatinase activity in tumor tissue and serum as a prognostic marker of naturally developing canine tumors. J Vet Med Sci. 67(8): 769-775.


5. Arulselvan, P., Wen, C.C., Lan, C.W., Chen, Y.H., Wei, W.C. and Yang, N.S. (2012) Dietary Administration of Scallion Extract Effectively Inhibits Colorectal Tumor Growth: Cellular and Molecular Mechanisms in Mice. PLoS One. 7(9):e44658.
PMid:23024755 PMCid:PMC3443092


6. Mederle, O., Mederie, N., Bocan, E., Ceausu, R. and Raica, M. VEGF (2010) expression in dog mastocytoma. Rev Med Chir Soc Med Nat Iasi. 114(1):185-188.


7. Kumar, V. (2012) Adenosine as an endogenous immunoregu- lator in cancer pathogenesis: where to go? Purinegic Signal. 9(2):145-65.
PMid:23271562 PMCid:PMC3646124


8. Lowe, B. and Storkun, W. (2011) Chronic inflammation and immunologic-based constraints in malignant disease. Immunotherapy. 3(10):1265-1274.
PMid:21995576 PMCid:PMC3225121


9. Scrivo, R., Vasile, M., Bartosiewicz, I. and Valesini, G. (2011) Inflammation as "common soil" of the multifactorial diseases. Autoimmun Rev. 10(7):369-374.


10. Sethl, G., Shanmugam, M., Ramachandran, L., Kumar, A. and Terganonkar V. (2012) Multifaceted link between cancer and inflammation. Biosci Rep. 32(1):1-15.


11. Stix, G. A. (2007) malignant flame. Understanding chronic inflammation, which contributes to heart disease, Alzheimer's and a variety of other ailments, may be a key to unlocking the mysteries of cancer. Sci Am. 297(1):60-67.


12. Egger, G. (2011) Obesity, Chronic Disease, and Economic Growth: A Case for "Big Picture" Prevention. Advances in Preventive Medicine. 26 (10): 149-158.


13. Zoran, D. (2010) Obesity in dogs and cats: a metabolic and endocrine disorder. Vet Clin North Am Small Anim Pract. 417-418:183-188.


14. Hickman, M. (1998) Interventional nutrition for gastro- intestinal disease. Clin Tech Small Anim Pract. 13(4):211- 216.


15. Johnson, P. (2010) Dogs in Biomedical research. [Lecture]. Accessed December 28, 2012.


16. Kozak, L., Koza, R. and Anunciado-Koza, R. (2010) Brown fat thermogenesis and body weight regulation in mice: relevance to humans. Int J Obes (Lond). 34(Suppl 1):S23-27.


17. Tvarijonaviciute, A., Ceron, J., Holden, S., Cuthbertson, D., Biourge, V., Morris, P. and German, A. (2012) Obesity- related metabolic dysfunction in dogs: a comparison with human metabolic syndrome. BMC Vet Res. 8(1):147.
PMid:22929809 PMCid:PMC3514388


18. Hill, R. (2009) Conference on "Multidisciplinary approaches to nutritional problems". Symposium on "Nutrition and health". Nutritional theapies to improve health: lessons from companion animals. Proc Nutr Soc. 68(1):98-102.


19. Rowell, J., McCarthy, D. and Alvarez, C. (2011) Dog Models of naturally occurring cancer. Trends Mol Med. 17(7):380- 388.
PMid:21439907 PMCid:PMC3130881


20. Salminen, A., Kaarniranta, K. and Kauppinen, A. (2012) Inflammaging:disturbed interplay between autophagy and inflammasomes. Aging (Albany NY). 4(3):166-175.


21. Weber K, Schmahl W. and Munch G. (1998) Distribution of advanced glycation end products in the cerebellar neurons of dogs. Brain Res. 791(1-2):11-17.


22. Yuki, M., Itoh, H. and Takase, K. (2010) Serum alpha-1-acid glycoprotein concentration in clinically healthy puppies and adult dogs and in dogs with various diseases. Vet Clin Pathol. 39(1):65-71.


23. Murua Escobar, H., Meher, B., Richter, A., Becker, K., Flohr, A., Bullerdiek, J. and Nolte, I. (2003) Molecular charac- terization of the canine HMGB1. Cytogenet Genome Res. 101(1):33-38.


24. Gil, A., Olza, J., Gil-Campos, M., Gomez-Llorente, C. and Aquilera, C. (2011) Is adipose tissue metabolically different at different sites? Int J Pediatr Obes. 6(Suppl 1):13-20.


25. Cook, A. and Cowan, C. (2008-2009) Adipose. Stembook [Internet].2008-2009. Accessed Jan 7, 2013.


26. Tetè, S., Nicoletti, M., Saggini, A., Maccauro, G., Rosati, M., Conti, F., Cianchetti, E., Tripodi, D., Toniato, E., Fulcheri, M., Salini, V., Caraffa, A., Antinolfi, P., Frydas, S., Pandolfi, F., Conti, P. and Potalivo, G. (2012)Nutrition and cancer prevention. Int J Immunopathol Pharmacol. 25(3):573-581.


27. Gugliucci, A., Kotani, K., Taing, J., Matsuoka, Y., Sano, Y., Yoshimura, M., Egawa, K., Horikawa, C., Kitagawa, Y., Kiso, Y., Kimura, S. and Sakane, N. (2009) Short-Term Low Calorie Diet Intervention Reduces Serum Advanced Glycation End Products in Healthy Overweight or Obese Adults. Annals of Nutrition & Metabolism. 54(3):197-201.


28. Tsukahara, H., Ohta, N., Sato, S., Hiraoka, M., Shukunami, K., Uchiyama, M., Kawakami, H., Sekine, K. and Mayumi, M. (2004) Concentrations of pentosidine, an advanced glycaiton end-product, in umbilical cord blood. Free Radic Res. 38(7):691-695.


29. Heerwagen, M., Miller, M., Barbour, L. and Friedman, J. (2010) Maternal obesity and fetal metabolic programming: a fertile epigenetic soil. Am J Physiol Regul Integr Comp Physiol. 299(3):R711-722.
PMid:20631295 PMCid:PMC2944425


30. Koletzko, B., Brands, B., Poston, L., Godfrey, K. and Demmelmair, H. (2012) Early nutrition programming of long-term health. Proc Nutr Soc. 18:1-8.


31. Reik, W., Dean, W. and Walter, J. (2001) Epigenetic repro- gramming in mammalian development. Science. 293 (5532): 1089-1093.


32. Cinti, S. (2011) Between brown and white: novel aspects of adipocyte differentiation. Ann Med. 43(2):104-115.


33. Nikoopoulos, D., Theocharis, S. and Kouraklis G. Ghrelin (2010) a potential therapeutic target for cancer. Requl Pept. 163(1-3):7-17.


34. Sparkes, A. (2011) Feeding old cats--an update on new nutritional therapies. Top Companion Anim Med. 26(1):37- 42.


35. Bagnell, C., Steinetz, B. and Bartol, F. (2009) Milk-borne relaxin and the lactocrine hypothesis for materman programming of neonatal tissues. Ann N Y Acad Sci. 1160: 152-157.


36. Yamagishi, S., Ueda, S. and Okuda, S. (2007) Food-derived advanced glycation end products (AGEs): a novel therapeutic target for various disorders. Curr Pharm Des. 13(27):2832- 2836.


37. German, A., Ryan, V., German, A., Wood, I. and Trayburn, P. (2010) Obesity, its associated disorders and the role of inflammatory adipokines in companion animals. Vet J. 185 (1):4-9.


38. Birlouez-Aragon, I., Morales, F., Fogliano, V. and Pain, J. (2010) The health and technological implications of a better control of neoformed contaminants by the food industry. Pathol Biol 58(3):232-238.


39. Uribarri, J., Woodruff, S., Goodman, S., Cai, W., Chen, X., Pyzik, R., Yong, A., Striker, G. and Vlassara, H. (2010) Advanced glycation end products in foods and a practical guide to their reduction in the diet. J Am Diet Assoc. 110(6): 911-916, e912.


40. Perez-Calvo, E., Castrillo, C., Baucells, M. and Guada, J. (2010) Effect of rendering on protein and fat quality of animal by-products. J Anim Physiol Anim Nutr 94(5):e154- 163.


41. Delgado-Andrade, C., Rufian-Herares, J., Nieto, R., Aquilera, J., Navarro, M. and Seiquer, I. (2010) Does the pelleting process affect the nutritive value of a pre-starter diet for sucking piglets? Ex vivo studies on mineral absorption. J Sci Food Agric. 90(5):898-905.


42. Stadler, R., Blank, I., Varga, N., Robert, F., Hau, J., Guy, P., Robert, M. and Riediker, S. (2002) Acrylamide from Maillard reaction products. Nature. 419(6906):449-450.


43. Friedman, M. and Levin, C. (2008) Review of methods for the reduction of dietary content and toxicity of acrylamide. J Agric Food Chem. 56(15):6113-6140.


44. Tareke, E., Rydberg, P., Karlsson, P. and Tornqvist, M. (2002) Analysis of acrylamide, a carcinogen formed in heated foodstuffs. J Agric Food Chem. 50(17):4998-5006.


45. Semba, R., Nicklett, E. and Ferrucci, L. (2010) Does accumulation of advanced glycation end products contribute to the aging phenotype? J Gerontol 65(9):963-975.


46. Sterenczak, K, Nolte, I. and Escobar, H. (2013) RAGE Splicing Variants in Mammals. In: Heizmann CW, ed. Calcium-Binding Proteins and RAGE. Vol 963: Humana Press. pp.265-276.


47. Luevano-Contreras, C. and Chapman-Novakofski, K. (2010) Dietary advanced glycation end products and aging. Nutrients. 2(12):1247-1265.
PMid:22254007 PMCid:PMC3257625


48. Uribarri, J., Cai, W., Sandu, O., Peppa, M., Goldberg, T. and Vlassara, H. (2005) Diet-derived advanced glycaiton end products are major contributors to the body's AGE pool and induce inflammation in healthy subjects. Ann N Y Acad Sci. 1043:461-466.


49. Tessier, F. and Birlouez-Aragon, I. (2012) Health effects of dietary Maillard reaction products: the results of ICARE and other studies. Amino Acids. 42(4):1119-1131.


50. Song, F. and Schmidt, A. (2012) Glycation and insulin resistance: novel mechanisms and unique targets? Arterioscler Thromb Vasc Biol. 32(8):1760-1765.


51. Ramasamy, R., Yan, S. and Schmidt, A. (2012) Advanced glycation endproducts: from precursors to RAGE: round and round we go. Amino Acids. 42(4):1151-1161.
PMid:20957395 PMCid:PMC3062728


52. Goldin, A., Beckman, J.A., Schmidt, A.M. and Creager, M.A. (2006) Advanced Glycation End Products: Sparking the Development of Diabetic Vascular Injury. Circulation. 114 (6):597-605.


53. Negre-Salvayre, A., Coatrieux, C., Inguerneau, C. and Salvayre, R. (2008) Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors. Br J Pharmacol. 153(1):6-20.
PMid:17643134 PMCid:PMC2199390


54. Giunta, B., Fernadndez, F., Nikolic, W., Obregon, D., Rrapo, E., Town, T. and Tan, J. (2008)Inflammaging as a prodrome to Alzheimer's disease. J Neuroinflammation. 5: 51.
PMid:19014446 PMCid:PMC2615427


55. Egger, G. and Dixon, J. (2009) Obesity and chronic disease; always offender or often just accomplice? Br J Nutr. 102 (8): 1238-1242.


56. Laflamme, D. (2012) Companion Animals Symposium: Obesity in dogs and cats: what is wrong with being fat? J Anim Sci. 90(5):1653-1662.


57. Cave, N. (2003) Chronic inflammatory disorders of the gastrointestinal tract of companion animals. N Z Vet J. 51 (6): 262-274.


58. Goldberg, T., Cai, W., Peppa, M, Dardaine V, Baliga B, Uribarri J, Vlassara H. (2004) Advanced glycoxidation end products in commonly consumed foods. J Am Diet Assoc. 104(8):1287-1291.


59. Asif, M., Egan, J., Vasan, S., Jyothirmayi, G.N., Masurekar, M.R., Lopez, S., Williams, C., Torres, R.L., Wagle, D., Ulrich, P., Cerami, A., Brines, M. and Regan, T.J. (2000) An advanced glycaiton endproduct cross-link breaker can reverse age-related increases in myocardial stiffness. Proc Natl Acad Sci U S A 97(14):2809-2813.
PMid:10706607 PMCid:PMC16011


60. Graeber, M., Li, W. and Rodriques, M. (2011) Role of microglia in CNS inflammation. FEBS Lett. 585(23):3798- 3805.


61. Macaulay, R., Akbar, A. and Hensen, S. (2012) The role of the T cell in age-related inflammation. Age . 35(3):563-72.



62. Neuhouser, M.L., Schwarz, Y., Wang, C., Breymeyer, K., Coronado, G., Wang, C.Y., Noar, K., Song, X. and Lampe, J.W. (2012) A Low-Glycemic Load Diet Reduces Serum C- Reactive Protein and Modestly Increases Adiponectin in Overweight and Obese Adults. The Journal of Nutrition. 142(2):369-374.
PMid:22190020 PMCid:PMC3260063



63. Ogilvie, G. (1998) Interventional nutrition for the cancer patient. Clin Tech Small Anim Pract. 13(4):224-231.



64. Massimino, S., McBurney, M., Field, C., Thomson, A., Keelan, M., Hayek, M. and Sunvoid, G. (1998) Fermentable dietary fiber increases GLP-1 secretion and improves glucose homeostasis despite increased intestinal glucose transport capacity in healthy dogs. J Nutr. 128(10): 1786- 1793.



65. Rose, D., DeMeo, M., Keshavarzian, A. and Hamaker, B. (2007) Influence of dietary fiber on inflammatory bowel disease and colon cancer importance of fermentation pattern. Mutr Rev. 65(2):51-62.



66. Silvio, J., Harmon, D., Gross, K. and McLeod, K. (2000) Influence of fiber fermentability on nutrient digestion in the dog. Nutrition. 16(4):289-295.



67. Ogilvie, G., Fettman, M., Mallinckrodt, C., Walton, J., Hansen, R., Davenport, D., Gross, K., Richardson, K., Rogers, Q. and Hand, M. (2000) Effect of fish oil, arginine, and doxorubicin chemotherapy on remission and survival time for dogs with lymphoma: a souble-blind, randomized placebo-controlled study. Cancer. Apr 88 (8): 1916-1928.



68. Chua, W., Clarke, S. and Charles, K. (2012) Systemic inflammation and prediction of chemotherapy outcomes in patients receiving docetaxel for advanced cancer. Support Care Cancer. 20(8):1869-1874.



69. Kim, M., Kim, K., Han, J., Lim, J. and Song, Y. (2011) Modulation of inflammatory signaling pathways by phytochemicals in ovarian cancer. Genes Nutr. 6(2):109- 115.
PMid:21484164 PMCid:PMC3092902



70. Kuniyasu, H., Oue, N., Wakikawa, A., Shigeishi, H., Matsutani, N., Kuraoka, K., Ito, R., Yokozaki, H. and Yasui, W. (2002) Expression of receptors for advanced glycation end-products (RAGE) is closely associated with the invasive and metastatic activity of gastric cancer. The Journal of Pathology. 196(2):163-170.



71. Stehno-Bittel, L. (2008) Intricacies of fat. Phys Ther. 88 (11): 1268-1278.



72. Ryan, V., German, A., Wood, I., Hunter, L., Morris, P. and Trayhurn, P. (2010) Adipokine expression and secretion by canine adipocytes: stimulation of inflammatory adipokine production by LPS and TNFalpha. Pflugers Arch. 460 (3): 603-616.



73. Burns, P. A. (2011) Brief History of Dog Food. In: Burns P, ed. Terrierman's Daily Dose. Vol 2011. Aug 9, 2008 ed. Arlington, VA2008.



74. Hill, S.R. (2010) Changing the metabolism of dogs (canis familiaris) and cats (Felis catus) at rest and during exercise by manipulation of dietary macronutrients. Palmerston North, New Zealand: Nutritional Science, Massey University.



75. Adler, C.J., Dobney, K., Weyrich, L.S., Kaidonis, J., Walker, A.W., Haak, W., Bradshaw, C.J.A., Townsend, G., Soltysiak, A., Alt, K.W., Parkhill, J. and Cooper, A. (2013) Sequencing ancient calcified dental plaque shows changes in oral microbiota with dietary shifts of the Neolithic and Industrial revolutions. Nat Genet. 45(4):450-5.



76. Adler, C.J., Haak, W., Donlon, D. and Cooper, A. (2011) Survival and recovery of DNA from ancient teeth and bones. Journal of Archaeological Science. 38(5):956-964.



77. Simopoulos, A. (2009) A Balanced Omega-6/Omega-3 Fatty Acid Ratio, Cholesterol and Coronary Heart Disease. 100: 1- 2.



78. Simopoulos, A. (2008) The importance of the omeaga-6/ omega-3 fatty acid ratio in cardiovascular disease and the other chronic diseases. Exp Biol Med (Maywood). 233(6): 674-688.



79. Egger, G. (2012) In search of a germ theory equivalent for chronic disease. Prev Chronic Dis. 9:E95.
PMid:22575080 PMCid:PMC3431950



80. Egger, G. and Dixon, J. (2010) Inflammatory effects of nutritional stimuli: further support for the need for a big picture approach to tackling obesity and chronic disease. Obes Rev. 11(2):137-149.



81. O'Connor, J., Stowe, C. and Robinson, R. (1985) Fate of sodium pentobarbital in rendered products. Am J Vet Res. 48(8): 1721-1724.



82. Myers, M. (2004) CVM Scientists develop PCR test to determine source of animal products in feed, pet food. Veterinarian Newsletter [Online] Accessed December 27, 2012.



83. Taylor, D. and Woodgate, S. (2003) Rendering practices and inactivation of transmissible spongiform encephalopathy agents. Rev Sci Tech. 22(1):297-310.



84. USDA. (2011) BSE and the safety of pets. Accessed December 28, 2012.



85. Accessed December 30, 2012.




86. CDC (2012) Human Salmonella Infantis infections linked to dry dog food- United States and Canada, 2012. Morbidity and Mortality Weekly Report (MMWR). 61(23):436.



87. Case, L. (2005) Nutrient requirements of the dog. The Dog: Its behaviror, nutrition and health. 2nd ed. Iowa, USA: Blackwell Publishing Professional.



88. CEBM (2009) Oxford Centre for Evidence-based Medicine - Levels of Evidence. index. aspx? o= 1025. Accessed December 27, 2012.



89. Bosch, G., Pellikaan, W., Rutten, G., van der Poel, A., Verstegen, M. and Hendriks, W. (2008) Comparative in vitro fermentation activity in the canine distal gastrointestinal tract and fermentation kinetics of fiber sources. J Anim Sci. 86(11):2979-2989.



90. Adolphe, J., Drew, M., Huang, Q., Silver, T. and Weber, L. (2012) Postprandial impairment of flow-mediated dilation and elevated methylglyoxal after simple but not comples carohydrate consumption in dogs. Nutr Res. 32(4):278-284.



91. Accessed February 19, 2013.



92. Hu, J., La Vecchia, C., Augustin, L., Negri, E., de Groh, M., Morrison, H. and Mery, L. (2013) Gyycemic index, glycemic load and cancer risk. Ann Oncol. 24(1):245-251.



93. Barclay, A., Petocz, P., McMillan-Price, J., Flood, V., Prvan, T., Mitchell, P., Brand-Miller, J. (2008) Glycemic index, glycemic load, and chronic disease risk--a meta-analysis of observational studies. Am J Clin Nutr. 87(3):627-637.



94. Brownlee, I., Moore, C., Chatfield, M., Richardson, D., Ashby, P., Kuznesof, S., Jebb, S. and Seal, C. (2010) Markers of cardiovascular risk are not changed by increased whole- grain intake: Whole heart study, a randomised, controlled dietary intervention. Br J Nutr. 104(1):125-134.
PMid:20307353 PMCid:PMC3501710



95. Nachman, K., Raber, G., Francesconi, K., Navas-Acien, A. and Love, D. (2012) Arsenic species in poultry feather meal. Sci Total Environ. 417-418.



96. Lasekan, A., Abu Bakar, F. and Hashim, D. (2012) Potential of chicken by-products as sources of useful biological resources. Waste Manag. pil: S0956-053X(12):00367-00364.



97. Lasky, T., Sun, W., Kadry, A. and Hoffman, M. (2004) Mean total arsenic concentrations in chicken 1989-2000 and estimated exposures for consumers of chicken. Environ Health Perspect. 112(1):18-21.
PMid:14698925 PMCid:PMC1241791



98. Magos, L. (1991) Epidemiological and experimental aspects of metal carcinogenesis: physicochemical properties, kinetics, and the active species. Environ Health Perspect. 95:157-189.
PMid:1821370 PMCid:PMC1568407



99. Accessed December 27, 2012, 2012.



100. Clutton-Brock, J. (1977) Man-made dogs. Science. 197 (4311):1340-1342.



101. Li, W., Li, V., Hutnik, M. and Chiou, A. (2012) Tumor angiogenesis as a target for dietary cancer prevention. J Oncol. 2012:879623.
PMid:21977033 PMCid:PMC3184418



102. Aggarwal, B., Ichikawa, H., Garodia, P., Weerasinghe, P., Sethi, G., Bhatt, I., Pandey, M., Shishodia, S. and Nair. M. (2006) From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer. Expert Opin Ther Targets. 10(1):89-118.



103. Krol, M., Pawlowski, K., Majchrzak, K., Gajewska, M., Majewska, A. and Motyl, T. (2012) Global gene expression profiles of canine macrophages and canine mammary cancer cells grown as a co-culture in vitro. BMC Veterinary Research. 8(1):16.
PMid:22353646 PMCid:PMC3315417



104. Sterenczak, K.A., Willenbrock, S., Barann, M., Klemke, M., Soller, J.T., Eberle, N., Nolte, I., Bullerdiek, J. and Escobar, H.M. (2009) Cloning, characterisation, and comparative quantitative expression analyses of receptor for advanced glycation end products (RAGE) transcript forms. Gene. 434 (1–2):35-42.



105. Schmidt, A.M., Yan, S.D., Yan, S.F. and Stern, D.M. (2000) The biology of the receptor for advanced glycation end products and its ligands. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1498(2–3):99-111.



106. Chase, D., McLauchlan, G., Eckersall, P.D., Parkin, T., Pratschke, K. and Pratschke, J. (2013) Acute phase protein levels in dogs with mast cell tumours and sarcomas. Veterinary Record. 170(25):648.



107. Wolfesberger, B., Hoelzl, C., Walter, I., Reider, G.A., Fertl, G., Thalhammer, J.G., Skalicky, M. and Egerbacher, M. (2006) In vitro effects of meloxicam with or without doxorubicin on canine osteosarcoma cells. Journal of Veterinary Pharmacology and Therapeutics. 29(1):15-23.



108. Zuccari, D., Castro, R., Gelaleti, G. and Mancini, U. (2011) Interleukin-8 expression associated with canine mammary tumors. Genet Mol Res. 10(3):1522-1532.



109. Willenbrock, S., Braun, O., Baumgart, J., Lange, S., Junghanss, C., Heisterkamp, A., Nolte, I., Bullerdiek, J., Murua Escobar, H. (2012) TNF-a induced secretion of HMGB1 from non-immune canine mammary epithelial cells (MTH53A). Cytokine. 57(2):210-220.



110. Tamburini, B., Phang, T., Fosmire, S., Scott, M., Trapp, S., Duckett, M., Robinson, S., Slansky, J., Sharkey, L., Cutter, G., Wojcieszyn, J., Bellgrau, D., Gemmill, R., Hunter, L. and Modiano, J. (2010) Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma. BMC Cancer. 10(1):619.
PMid:21062482 PMCid:PMC2994824



111. Brunker, J. and Hoover, J. (2007) B-cell lymphoma in a dog with ehrlichiosis (Ehrlichia canis) and systemic histoplasmosis (Histoplasma capsulatum). Can Vet J. 48(3): 292-295.
PMid:17436907 PMCid:PMC1800954



112. Sterenczk, K. A., Kleinschmidt, S., Wefstaedt, P., Eberle, N., Hewicker-Trautwein, M., Bullerdiek, J., Nolte, I. and Escobar, M. (2011) Quantitative PCR and Immunohistoche- mical Analyses of HMGB1 and RAGE Expression in Canine Disseminated Histiocytic Sarcoma (Malignant Histiocytosis). Anticancer Research. 31(5):1541-1548.



113. Sterenczk, K. A., Joetzke, A.E., Willenbrock, S., Eberle, N., Lange, S., Junghanss, C., Nolete, I., Bullerdiek, J. Simon, D. and Escobar, H.M. (2010) High-mobility Group B1 (HMGB1) and Receptor for Advanced Glycation End- products (RAGE) Expression in Canine Lymphoma. Anticancer Research. 30(12):5043-5048.



114. Wilson, H., Chadalapaka, G., Jutooru, I., Sheppard, S., Pfent, C. and Safe, S. (2012) Effect of Tolfenamic Acid on Canine Cancer Cell Proliferation, Specificity Protein (Sp) Transcription Factors, and Sp-Regulated Proteins in Canine Osteosarcoma, Mammary Carcinoma, and Melanoma Cells. Journal of Veterinary Internal Medicine. 26(4):977-986.



115. Mercer, N., Ahmed, H., Etcheverry, S., Vasta, G. and Cortizo, A. (2007) Regulation of advanced glycation end product (AGE) receptors and apoptosis by AGEs in osteoblast-like cells. Molecular and Cellular Biochemistry. 306(1-2):87-94.



116. Mercer, N., Ahmed, H., McCarthy, A., Etcheverry S, Vasta G. and Cortizo A. (2004)AGE-R3/galectin-3 expression in osteoblast-like cells: regulation by AGEs. Mol Cell Biochem. 266(1-2):17-24.



117. Misdorp, W. (2004) Mast cells and canine mast cell tumours. A review. Veterinary Quarterly. 26(4):156-169.



118. Yoshimaru, T., Suzuki, Y., Inoue, T., Nishida, S. and Ra, C. (2008) Extracellular superoxide released from mitochondria mediates mast cell death by advanced glycation end products. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1783(12):2332-2343.