Open Access
Copyright: The authors. This article is an open access
article licensed under the terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/2.0) which permits unrestricted use,
distribution and reproduction in any medium, provided the work is properly
cited.
Research
(Published
online: 23-12-2014)
14.
Comparative efficacy
of crystalloid and colloid-crystalloid combination for the
management of hemorrhagic gastroenteritis in dogs -
Chandreyee Sen, Ashwani K. Sharma and P. S. Dhaliwal
Veterinary World, 7(12): 1108-1112
doi:
10.14202/vetworld.2014.1108-1112
Chandreyee Sen:
Department of Veterinary Medicine, Guru Angad Dev Veterinary and
Animal Sciences University, Ludhiana, Punjab, India;
chandreyee.sen1710@gmail.com
Ashwani
K. Sharma:
Department of Veterinary Medicine, Guru Angad Dev Veterinary and
Animal Sciences University, Ludhiana, Punjab, India;
ashgadvasu@yahoo.com
P. S. Dhaliwal:
Department of Veterinary Medicine, Guru Angad Dev Veterinary and
Animal Sciences University, Ludhiana, Punjab, India;
dhaliwalpps@yhoo.com
Received: 21-06-2014, Revised: 10-10-2014, Accepted: 16-10-2014,
Published Online: 23-12-2014
Corresponding author:
Chandreyee Sen, e-mail: chandreyee.sen1710@gmail.com
Abstract
Aim:
In the present study, a therapeutic trial was conducted to
assess comparative efficacy of crystalloid plus colloid and
crystalloid intravenous infusions alone as fluid therapy in dogs
suffering from hemorrhagic gastroenteritis (HGE).
Materials and Methods: 20 dogs manifesting HGE, presented at
Teaching Veterinary Clinical Services Complex, Ludhiana, Punjab,
were selected randomly for the trial. All of them were observed to
suffer from moderate dehydration on clinical examination.
Crystalloids 5% DNS and RL were used in combination with polygelin
3.5% colloidal solution in the first group (Combination I) and in
the second group, the afore-said crystalloids (Combination II)
were used, both groups consisting of 10 cases each. Antibiotics
and symptomatic treatment were same for all the 20 cases. The
outcome of both treatment groups was evaluated on hemato-biochemical
parameters, before and after administration of the therapies and
compared statistically within and between the two groups. Hemato-biochemical
parameters of eight clinically healthy animals were considered as
control for comparison.
Result:
On hemato-biochemical examination, significant alterations
were observed in leucogram, platelet and serum globulin
concentration after the treatment in the first group as compared
to before treatment values. In the second group, mean hemoglobin
varied significantly after the treatment. After therapies were
administered, significant difference in serum globulin level and
albumin: Globulin was found in between the treatment groups
(Combination I and Combination II). Clinical recovery was faster
in the first group than the second group of animals.
Conclusion: On hemodynamic and laboratory data, efficacies of
both the fluid therapies were equivocal. Colloidal solutions may
hasten recovery in small animals suffering from gastrointestinal
crisis.
Keywords: colloid, crystalloid, dog, hemato-biochemical
studies, hemorrhagic-gastroenteritis.
References
1. Brown, A.J. and Otto, C.M. (2008) Fluid therapy in vomiting
and diarrhea. Vet. Clin. North Am. Small, 38(3): 653-675.
http://dx.doi.org/10.1016/j.cvsm.2008.01.008
PMid:18402889 |
|
|
2. Mensack, S. (2008) Fluid therapy: Options and rational
administration. Vet. Clin. North Am. Small, 38(3): 575-586.
http://dx.doi.org/10.1016/j.cvsm.2008.01.028
PMid:18402882 |
|
|
|
3. Chan, D.L. (2008) Colloids: Current recommendations. Vet.
Clin. North Am, Small, 38(3): 587-593. |
|
|
|
4. Boag, A. (2013) Managing pParvovirus cCases. In: 10th
Emergency and Critical Care UK Annual Congress, p200-207. |
|
|
5. Mazzaferro, E.M., Rudloff, E. and Kirby, R. (2002) The role
of albumin replacement in the critically ill veterinary
patient. J. Vet. Emerg. Crit. Care, 12(2): 113-124.
http://dx.doi.org/10.1046/j.1435-6935.2002.00025.x |
|
|
|
6. Huges, D. and Boag, A.K. (2011) Fluid therapy with
macromolecular plasma volume expanders. In: Di Bartola S.P.,
editor. Fluid, Electrolyte and Acid-Base Disorders in Small
Animal Practice. 4th ed. Saunders, Elsevier, St. Louis,
Missouri. p647-664. |
|
|
|
7. Chan, D.L., Rozanski, E.A., Freeman, L.M. and Rush JE.
(2001) Colloid osmotic pressure in health and disease. Compend,
Contin, Educ, Pract., 23: 886-904. |
|
|
8. Mazzaferro, E. and Powell, L.L. (2013) Fluid therapy for
the emergent small animal patient: crystalloids, colloids, and
albumin products. Vet. Clin. North Am. Small, 43(4): 721-374.
http://dx.doi.org/10.1016/j.cvsm.2013.03.003
PMid:23747257 |
|
|
9. Otto, C.M., Rieser, T.M., Brooks, M.B. and Russell, M.W.
(2000) Evidence of hypercoagulability in dogs with parvoviral
enteritis. J. Am. Vet. Med. Assoc., 217(10): 1500-1504.
http://dx.doi.org/10.2460/javma.2000.217.1500
PMid:11128540 |
|
|
|
10. Mazzaferro, E.M. (2008) Complications of fluid therapy.
Vet. Clin. North Am. Small, 38(3): 670-619. |
|
|
|
11. Aiello, S.E. and Moses, M.A., editors, (2013) The fluid
resuscitation plan: Emergency medicine and critical care. In:
Merck's Veterinary Manual. http://www.merckmanuals.com/vet/emergency_medicine_and_critical_care/fluid_therapy/the_fluid_resuscitation_plan.html
Accessed on 05-06-2014 . |
|
|
|
12. Rudloff, E. and Kirby, R. (2013) Colloid fluid therapy.
In: Bonagura, J.D. and Twedt, D.C., editors. Current
Veterinary Therapy XIV. WB Saunders, Philadelphia, p16-28. |
|
|
13. DiBartola, S.P., editor. (2011) Fluid, Electrolyte and
Acid-Base Disorders in Small Animal Practice. 4th ed.
Saunders, Elsevier, St. Louis, Missouri.
PMCid:PMC3215016 |
|
|
14. Wilkes, N.J., Woolf R., Mutch, M., Mallett, S.V., Peachey,
T., Stephens, R. and Mythen, M.G. (2001) The effects of
balanced versus saline-based hetastarch and crystalloid
solutions on acid-base and electrolyte status and gastric
mucosal perfusion in elderly surgical patients. Anesth. Analg.,
93(4): 811-816.
http://dx.doi.org/10.1097/00000539-200110000-00003
PMid:11574338 |
|
|
15. Rassam, S.S. and Counsell, D.J. (2005) Perioperative fluid
therapy. Contin. Educ. Anaesth. Crit. Care. Pain., 5(5):
161-165.
http://dx.doi.org/10.1093/bjaceaccp/mki043 |
|
|
16. Franz, A., Bräunlich, P., Gamsjäger, T., Felfernig, M.,
Gustorff, B. and Kozek-Langenecker, S.A. (2001) The effects of
hydroxyethyl starches of varying molecular weights on platelet
function. Anesth. Analg., 92(6): 1402-1407.
http://dx.doi.org/10.1097/00000539-200106000-00008
PMid:11375812 |
|
|
17. Gauthier, V., Holowaychuk, M.K., Kerr, C.L., Bersenas,
A.M. and Wood, R.D. (2014) Effect of synthetic colloid
administration on hemodynamic and laboratory variables in
healthy dogs and dogs with systemic inflammation. J. Vet.
Emerg. Crit. Care., 24(3): 251-258.
http://dx.doi.org/10.1111/vec.12188
PMid:24798178 |
|
|
|
18. Shahbazi, S., Zeighami, D., Allahyary, E., Alipour, A.,
Esmaeeli, M.J. and Ghaneie, M. (2011) Effect of colloid versus
crystalloid administration of cardiopulmonary bypass prime
solution on tissue and organ perfusion. Cell, 98: 9173172580. |
|
|
|
19. Roberts, I. and Alderson, P. (2004) Colloids versus
crystalloids for fluid resuscitation in critically ill
patients. Cochrane Database Syst. Rev., 4.: ??? . |
|
|
20. Fisher, M. (2008) Fluids. In: Fink, M., Hayes, M., Soni,
N., editors. Classic Papers in Critical Care. 2nd ed.
Springer, Oxfordshire, UK. p303.
http://dx.doi.org/10.1007/978-1-84800-145-9_12
PMid:18673471 |
|
