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Research (Published online: 09-12-2014)

5. Toxicopathological changes on Wistar rat after multiple exposures to acetamiprid - S. Mondal, R. C. Ghosh, S.S. Karnam and Kamal Purohit

Veterinary World, 7(12): 1058-1065



   doi: 10.14202/vetworld.2014.1058-1065



S. Mondal: Department of Veterinary Pathology, West Bengal University of Animal and Fishery Sciences, Kolkata, West Bengal,


R. C. Ghosh: Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Durg, Chhattisgarh,


S. S. Karnam: Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Durg, Chhattisgarh,


Kamal Purohit: Department of Veterinary Pathology, Rajasthan University of Veterinary & Animal Sciences, Rajasthan, India;


Received: 19-08-2014, Revised: 31-10-2014, Accepted: 03-11-2014, Published online: 09-12-2014


Corresponding author: Shiv Shankar Karnam, e-mail:

Aim: To see the toxicopathological changes after multiple exposure to acetamiprid (ACP) and also to obtain more information regarding the manner in which ACP acts at cellular level.

Materials and Methods: A subacute toxicity study of ACP was undertaken in 72 female Wistar rats in four groups (18 each). Three different concentrations of ACP (25, 100 and 200 mg/kg of body weight) were administered orally to rats. Untreated rats served as control. Different plasma enzyme and analytes were measured. Gross and histopathological observations were noted in this experiment.

Result: There was a significant increase in the plasma enzymes tested in this experiment. There was a significant decrease in plasma glucose, cholesterol and low-density lipid. Necrotic and degenerative changes were observed in vital organs.

Conclusion: It is observed that ACP has the toxic potential (on liver, kidney, heart, ovary and brain) at sub lethal doses.

Keywords: acetamiprid, histopathology, Wistar rat.

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