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Research
(Published
online: 09-12-2014)
5. Toxicopathological changes on Wistar rat
after multiple exposures to acetamiprid -
S. Mondal, R. C. Ghosh, S.S. Karnam and Kamal
Purohit
Veterinary World, 7(12): 1058-1065
doi:
10.14202/vetworld.2014.1058-1065
S. Mondal:
Department of Veterinary Pathology, West Bengal University of
Animal and Fishery Sciences, Kolkata, West Bengal,
India;
vetsamiran@gmail.com
R. C. Ghosh:
Department of Veterinary Pathology, College of Veterinary Science
and Animal Husbandry, Durg, Chhattisgarh,
India;
rcghosh@rediffmail.com
S. S. Karnam:
Department of Veterinary Pathology, College of Veterinary Science
and Animal Husbandry, Durg, Chhattisgarh,
India;
dr.shiv.vet82@gmail.com
Kamal
Purohit: Department of Veterinary Pathology, Rajasthan
University of Veterinary & Animal Sciences, Rajasthan, India;
drkpurohit@rediffmail.com
Received:
19-08-2014, Revised: 31-10-2014, Accepted: 03-11-2014, Published
online: 09-12-2014
Corresponding author:
Shiv Shankar Karnam, e-mail: dr.shiv.vet82@gmail.com
Abstract
Aim:
To see the toxicopathological changes after multiple exposure
to acetamiprid (ACP) and also to obtain more information regarding
the manner in which ACP acts at cellular level.
Materials and Methods: A subacute toxicity study of ACP was
undertaken in 72 female Wistar rats in four groups (18 each).
Three different concentrations of ACP (25, 100 and 200 mg/kg of
body weight) were administered orally to rats. Untreated rats
served as control. Different plasma enzyme and analytes were
measured. Gross and histopathological observations were noted in
this experiment.
Result:
There was a significant increase in the plasma enzymes tested
in this experiment. There was a significant decrease in plasma
glucose, cholesterol and low-density lipid. Necrotic and
degenerative changes were observed in vital organs.
Conclusion: It is observed that ACP has the
toxic potential (on liver, kidney, heart, ovary and brain) at sub
lethal doses.
Keywords: acetamiprid, histopathology,
Wistar rat.
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