Veterinary World

     Open access and peer reviewed journal  

ISSN (Online): 2231-0916

ISSN (Print): 0972-8988


Home l Editorial board l Instructions for authors l Reviewer guideline l Open access policy l Archives l FAQ

Open Access

Copyright: The authors. This article is an open access article licensed under the terms of the Creative Commons Attribution License ( which permits unrestricted use, distribution and reproduction in any medium, provided the work is properly cited.

Research (Published online: 27-07-2014)

17. Evaluation of anthelmintic activity of Nigerian ethnoveterinary plants Cassia occidentalis and Guiera senegalensis - Mohammed Musa Suleiman, Mohammed Mamman, Adamu Sidiama, Eserohene Jane Ighoja, Mohammad Tauheed and Ahmad Muhammad Talba
Veterinary World, 7(7): 536-541



   doi: 10.14202/vetworld.2014.536-541


Mohammed Musa Suleiman:
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria;

Mohammed Mamman: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria;

Adamu Sidiama: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria;

Eserohene Jane Ighoja: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria;
Mohammad Tauheed:
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria;

Ahmad Muhammad Talba: Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria;

Received: 11-04-2014, Revised: 13-06-2014, Accepted: 20-06-2014, Published online: 27-07-2014


Corresponding author: Mohammed Musa Suleiman, email:

1. Fentahun, T. and Luke, G. (2012) Small ruminant haemonchosis: Prevalence and associated determinants in randomly selected restaurants and hotels of Gondar Town, Ethiopia. Eur. J. Appl. Sci. 4: 168-172.
2. Ademola, I.O., Fagbemi, B.O. and Idowu, S.O. (2004) Evaluation of the anthelmintic activity of Khaya senegalensis extract against gastrointestinal nematodes of sheep: in vitro and in vivo studies. Vet. Parasitol. 122: 151- 164.
3. Martin, R.J. (1997) Modes of action of anthelmintic drugs. Vet. J. 154: 11-34.
4. Jabbar, A., Campbell, A.J.D., Charles, J.A. and Gasser, R.B. (2013) First report of anthelmintic resistance in Haemonchus contortus in Alpacas in Australia. Parasites & Vectors. 6:243-248.
PMid:23965333 PMCid:PMC3765834
5. Kumsa, B. and Wossene, A. (2006) Efficacy of albendazole and tetramisole anthelmintics against Haemonchus contortus in experimentally infected lambs. Int. J. Appl. Res. Vet. Med. 4: 94-99.
6. Yadav, P. and Singh, R. (2011) A review on anthelmintic drugs and their future scope. Int. J. Pharm. Pharm. Sci. 3: 17-21.
7. Githiori, J.B., Höglund, J., Waller, P.J. and Baker, R.L. (2004) Evaluation of anthelmintic properties of some plants used as livestock dewormers against Haemonchus contortus infections in sheep. Parasitology 129: 245-253.
8. Athanasiadou, S, Tzamaloukas, O., Kyriazakis, I., Jackson, F. and Coop, R.L. (2001) Testing for direct anthelmintic effects of bioactive forages against Trichostrongylus colubriformis in grazing sheep. Vet. Parasitol. 127: 233-243.
9. Tsiboukis, D., Sazakli, E., Jelastopulu, E. and Leotsinidis, M. (2013) Anthelmintics residues in raw milk. Assessing intake by a children population. Pol. J. Vet. Sci. 16: 85-91.
10. Vijayalakshmi, S., Ranjitha, J., Devirajeswari, V. and Bhagiyalakshmi, M. (2013) Pharmacological profile of Cassia occidentalis L – A review. Int. J. Pharm. Pharm. Sci. 5: 29-33.
11. Vedpriya, A., Sanjay, Y., Sandeep, K. and Yadav, J.P. (2010) Antimicrobial activity of Cassia occidentalis L (Leaf) against various human pathogenic microbes. Life Sci. Med. Res. 9: 1-11.
12. Jafri, M.A., Subhani, M.J., Javed, K. and Singh, S. (1999) Hepatoprotective activity of leaves of Cassia occidentalis against paracetamol and ethyl alcohol intoxification in rats. J. Ethnopharmacol. 66: 355-361.
13. Bhattacharyya, D., Mukherjee, R., Pandit, S., Das, N. and Sur, T.K. (2003) Prevention of carbon tetrachloride induced hepatotoxicity in rats by Himoliv. A polyherbal formulation. Ind. J. Pharmacol. 2003; 35:183-185.
14. Tona, L., Cimanga, R.K., Mesia, K., Musuamba, C.T., De Bruyne T. and Apers S. (2004) In vitro antiplasmodial activity of extracts and fractions from seven medicinal plants used in the Democratic Republic of Congo. J. Ethnopharmacol. 93: 27-32.
15. Akuodor, G.C., Essien, A.D., David-Oku, E., Chilaka, K.C., Akpan, J.L., Ezeokpo, B. and Ezeonwumelu, J.O.C. (2013). Gastroprotective effect of the aqueous leaf extract of Guiera senegalensis in albino rats. Asian Pac. J. Trop. Med. 771- 775.
16. Soetan, K.O., Lasisi, O.T. and Agboluaje A.K.1. (2011) Comparative assessment of in vitro anthelmintic effects of the aqueous extracts of the seeds and leaves of the African locust bean (Parkia biglobosa) on bovine nematode eggs. J. Cell Ani. Biol. 5: 109-112.
17. Akhtar, M.S., Iqbal, Z., Khan, M.N. and Lateef, M. (2000) Anthelmintic activity of medicinal plants with particular reference to their use in animals in Indo-Pakistan subcontinent. Small Ruminant Res. 38: 99-107.
18. Alawa, C.B.I., Adamu, A.M., Gefu, J.O., Ajanusi, O.J., Abdu, P.A., Chiezey, N.P., Alawa, J.N. and Bowman, D.D. (2003) In vitro screening of two Nigerian medicinal plants (Vernonia amygdalina and Annona senegalensis) for anthelmintic activity. Vet. Parasitol. 113: 73-81.
19. Carvalho, C.O., Chagas, A.C.S., Cotinguiba, F., Furlan, M., Brito, L.G., Chaves, F.C.M., Stephan, M.P., Bizzo, H.R. and Amarante, A.F.T. (2012) The anthelmintic effect of plant extracts on Haemonchus contortus and Strongyloides venezuelensis. Vet. Parasitol. 183, 260-268.
20. Tiwari, P., Kumar, B., Kaur, M., Kaur, G. and Kau, H. (2011) Phytochemical screening and extraction: A Review. Internationale Pharmaceutica Sciencia 1: 98-106.
21. Hansen, J. and Perry, B. (1994) The Epidemiology of Diagnosis and Control of Helminth parasites of Ruminants". International Laboratory for Research on Animal Diseases. Nairobi, Kenya. 121 p.
22. Coles, G.C., Bauer, C., Borgesteede, F.H.M., Geerts, S., Klei, T.R., Taylor, M.A. and Waller, P.J. (1992) World Association for the Advancement of Veterinary Parasitology (WAAVP) methods for the detection of anthelmintic resistance in nematodes of veterinary importance. Vet. Parasitol. 44: 35- 44.
23. Hubert, J. and Kerboeuf, D. (1992) A microlarval development assay for the detection of anthelmintic resistance in sheep nematodes. Vet. Rec. 130: 442-446.
24. Ademola, I.O. and Eloff, J.N. (2010) In vitro anthelmintic activity of Combretum molle (R. Br. ex G. Don) (Combretaceae) against Haemonchus contortus ova and larvae. Vet. Parasitol. 169: 198-203.
25. Kosalge, S.B. and Fursule, R.A. (2009) Investigation of in vitro anthelmintic activity of Thespesia lampas (Cav.). Asian J. Pharm. Clin. Res. 2: 69-71.
26. Partap, S., Kumar, S., Kumar, A., Sharma, N.K. and Jha, K.K. (2012) In vitro anthelmintic activity of Luffa cylindrica leaves in Indian adult earthworm. J. Pharmacog. Phytochem. 1: 27-30.
27. Simon, M.K., Ajanusi, O.J., Abubakar, M.S., Idris, A.L., Suleiman, M.M. (2012) The anthelmintic effect of aqueous methanol extract of Combretum molle (R. Br. x. G. Don) (Combretaceae) in lambs experimentally infected with Haemonchus contortus. Vet. Parasitol. 187: 280-284.
28. Danquah, C.A., Koffuor, G.A., Annan, K. and Ketor, E.C. (2012). The anthelmintic activity of Vernonia amygdalina (Asteraceae) and Alstonia boonei De Wild (Apocynaceae). J. Med. Biomed. Sci. 1: 21-27.
29. Dalziel, J.M. (1955) The Useful Plants of West Tropical Africa". Crown Agents for the Colonies, London, pp. 132- 133.
30. Gautam, G.K., Singh, D.P., Dhakad, U., Saini, A. and Krishna, R. (2014). Uses of some traditional medicinal Indian plants. Int. J. Chem Pharm. Sci. 2: 576-580.
31. World Health Organization (WHO) (2000) General Guidelines for Methodologies on Research and Evaluation of Traditional Medicine. 1 pp.
32. Githiori, J.B., Höglund, J., Waller, P.J. and Baker, R.L. (2002) Anthelmintic activity of preparations derived from Myrsine Africana and Rapanea melanophloeos against the nematode parasite, Haemonchus contortus, of sheep. J. Ethnopharmacol. 80: 187-191.
33. Oliveira, L.M.B., Bevilaqua, C.M.L., Costa, C.T.C., Macedo, I.T.F., Barros, R.S., Rodrigues, A.C.M., Camurc-Vasconcelos, A.L.F., Morais, S.M., Lima, Y.C., Vieira, L.S. and Navarro, A.M.C. (2003) Anthelmintic activity of Cocos nucifera L. against sheep gastrointestinal nematodes. Vet. Parasitol. 159: 55-59.
34. Lange, K., Olcott, D.D., Miller, J.E., Mosjidis, J.A., Terrill, T.H., Burke, J.M. and Kearney, M.T. (2006) Effect of sericea lespedeza (Lespedeza cuneata) fed as hay, on natural and experimental Haemonchus contortus infections in lambs. Vet. Parasitol. 141: 273-278.
35. Moreno, F.C., Gordon, I.J., Knox, M.R., Summer, P.M., Skerratd, L.F., Benvenutti, M.A. and Saumell, C.A. (2012) Anthelmintic efficacy of five tropical native Australian plants against Haemonchus contortus and Trichostrongylus colubriformis in experimentally infected goats (Capra hircus). Vet. Parasitol. 187: 237-243.
36. Al-Shaibani, I.R.M., Phulan, M.S. and Shiekh, M. (2009) Anthelmintic activity of Fumaria parviflora (Fumariaceae) against gastrointestinal nematodes of sheep. Int. J. Agric. Biol. 11: 431-436.
37. Githiori, J.B., Athansiadou, S. and Thamsborg, S.M. (2006) Use of plants novel approaches for control of gastro-intestinal helminths in livestock with emphasis on small ruminants. Vet. Parasitol. 139: 308-320.
38. Jimenez-Cisneros, B.E. and Maya-Rendon, C. (2007) Helminths and sanitation. In: Méndez-Vilas, A. (Ed.), Communicating Current Research and Educational Topics and Trends in Applied Microbiology, 1: 60-71.
39. Purwal, L., Shrivastava, V., Makode, K.K. and Jain, U.K. (2010). Anthelmintic activity of aqueous extracts of some saponin containing medicinal plants. Der Pharmacia Lettre. 2: 476-481.
40. Melzig, M.F., Bader, G. and Loose, R. (2001) Investigations of the mechanism of membrane activity of selected triterpenoid saponins. Planta Med. 67: 43-48.
41. Bahuaud, D., Martinez-Ortiz De Montellano, C., Chauveau, S., Prevot, F., Torres-Acosta, F., Fouraste, I. and Hoste, H. (2006) Effects of four tanniferous plant extracts on the in vitro exsheathment of third-stage larvae of parasitic nematodes. Parasitology 132: 545-554.
42. Thompson, D.P., Geary, T.G., (1995) "The Structure and Function of Helminth Surfaces". In: Marr, J.J. (ed.), Biochemistry and Molecular Biology of Parasites, 1st edition. Academic Press, New York, pp. 203-232.
43. Akuodor, G.C., Essien, A.D., David-Oku, E., Chilaka, K.C., Akpan, J.L., Ezeokpo, B. and Ezeonwumelu, J.O.C. (2013). Gastroprotective effect of the aqueous leaf extract of Guiera senegalensis in albino rats. Asian Pacific J. Trop. Med. 13: 771-775.
44. Mariod, A., Matthäus, B. and Hussein, I.H. (2006) Antioxidant activities of extracts from Combretum hartmannianum and Guiera senegalensis on the oxidative stability of sunflower oil. Emirate J. Agric. Sci. 18: 20-28.
45. Xanthopoulou, M., Nomikos, T., Fragopoulou, E. and Antonopoulou, S. (2009) Antioxidant and lipoxygenase inhibitory activities of pumpkin seed extracts. Food Res. Int. 42 (5-6): 641-646.