Veterinary World

     Open access and peer reviewed journal  

ISSN (Online): 2231-0916

ISSN (Print): 0972-8988

 

Home l Editorial board l Instructions for authors l Reviewer guideline l Open access policy l Archives l FAQ


Open Access

Copyright: The authors. This article is an open access article licensed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0) which permits unrestricted use, distribution and reproduction in any medium, provided the work is properly cited.


Research (Published online: 16-07-2014)

9. Subacute toxicopathological studies of methotrexate in Wistar rats - N. N. Patel, D. J. Ghodasara, Sunanda Pandey, Priya D. Ghodasara, J. H. Khorajiya, B. P. Joshi and C. J. Dave
Veterinary World, 7(7): 489-495

 

 

   doi: 10.14202/vetworld.2014.489-495

 


N. N. Patel: Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat - 388001, India; nupur1989@gmail.com

D. J. Ghodasara: Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat - 388001, India; dinghodasara@gmail.com

Sunanda Pandey: Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat - 388001, India; drsunandapandey@gmail.com

Priya D. Ghodasara: Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat - 388001, India; priyaghodasara@yahoo.com

J. H. Khorajiya: Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat - 388001, India; jainudeen_1990@rediffmail.com

B. P. Joshi: Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat - 388001, India; b4bpjoshi@gmail.com

C. J. Dave: Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat - 388001, India; c4cjdave@gmail.com


Received: 11-04-2014, Revised: 07-06-2014, Accepted: 11-06-2014, Published online: 16-07-2014

 

Corresponding author: D. J. Ghodasara, email: dinghodasara@gmail.com





1. Kremer, J. M. and Lee, J. K. (1988) A long term prospective study of the use of methotrexate in rheumatoid arthritis. Arthritis Rheum., 31: 577-584.
http://dx.doi.org/10.1002/art.1780310501
PMid:3288222
 
2. Harris, E. D. (1990) Rheumatoid arthritis. Pathophysiology and implication for therapy. N Engl.J. Med. 322: 1277-1289.
http://dx.doi.org/10.1056/NEJM199005033221805
PMid:2271017
 
3. Clavel, M., Vermorken, J. B. and Cognetti, F. (1994) Randomized comparison of cisplatin, methotrexate, bleomycin and vincristine versus cisplatin and 5 - fluorouracil versus cisplatin in recurrent or metastatic squamous cell carcinoma of the head and neck. A phase III study of the EORTC head and neck cancer co-operative group. Ann. Oncol. 5: 521-526.
PMid:7522527
 
4. Sterling, G. (1997) Methotrexate hepatotoxicity. Rheum Dis Clin N Am. 23(4): 883-915.
http://dx.doi.org/10.1016/S0889-857X(05)70365-3
 
5. Hall, P. D., Jenner, M. A. and Ahern, M. J. (1991) Hepatotoxicity in a rat model caused by orally administered methotrexate. Hepatology. 14(5): 906-10.
http://dx.doi.org/10.1002/hep.1840140525
PMid:1937394
 
6. Cash, J. M. and Klippel, J. H. (1994) Second line drug therapy for rheumatoid arthritis. N Engl J Med. 330: 1368- 1375.
http://dx.doi.org/10.1056/NEJM199405123301908
PMid:8152450
 
7. Sorg, D. A. and Buckner, B. (1964) A simple method of obtaining venous blood from small laboratory animals. Exp Biol Med. 115: 1131-2.
http://dx.doi.org/10.3181/00379727-115-29134
 
8. Ermens, A. A. M., Schoester, M., Spijkers, L. J. M., Lindemans, J. and Abels, J. (1989) Toxicity of methotrexate in rat pre - exposed to nitrous oxide. Cancer Res. 49: 6337- 6341.
PMid:2804978
 
9. Boukhettala, N., Leblond, J., Claeyssens, S., Faure, M., Pessot, F. L., Feysot, C. B., Hassan, A., Mettraux, C., Vuichoud, J., Lavoinne, A., Breuille, D., De'chelotte, P. and Coeffier, M. (2009) Intestinal mucositis and alters gut protein metabolism independently of reduced food intake. Am J Physiol-Endoc M. 296: 182-190.
 
10. Perianayagasamy, A. M., Gomez, P. P. and Dhasarathan, P. (2010) Therapeutical effect of melatonin and glutamine against rats bone marrow toxicity induced by methotrexate. J. Bio sci. Res .1(3): 202-207.
 
11. Karri, S. and Vanithakumari, G. (2011) Effect of methotrexate and leucovorin on female reproductive tract of albino rats. Cell Biochem Funct. 29: 121.
http://dx.doi.org/10.1002/cbf.1711
PMid:21213337
 
12. Ohbayashi, M., Suzuki, M., Yashiro, Y., Fukuwaka, S., Yasuda, M., Kohyama, N., Kobayashi, Y. and Yamamoto, T. (2010) Induction of pulmonary fibrosis by methotrexate treatment in mice lung in vivo and in vitro. J Toxicol Sci. 35(5): 653-661.
http://dx.doi.org/10.2131/jts.35.653
PMid:20930460
 
13. Rofe, A. M., Bourgeois, C. S., Washington, J. M., Philcox, J. C. and Coyle, P. (1994) Metabolic consequences of methotrexate therapy in tumour bearing rats. Immunol Cell Biol. 72: 43-48.
http://dx.doi.org/10.1038/icb.1994.7
PMid:8157287
 
14. Bussanich, M. N., Rootman, J., Kumi, C. and Gudauskas, G. (1985) Ocular absorption and toxicity of methotrexate in the dog. Can. Vet J. 26: 263-266.
PMid:17422568 PMCid:PMC1680102
 
15. Robert, M. F., Buckler, C. E. and Baron, S. (1961) The effect of amino methyl pteroylglutamic acid on the development of skin hypersensitivity and on antibody formation in guinea pigs. United States Department of Health, Education and Welfare, Public Health Service, National Institute of Health, Division of Biologics Standards, laboratory of viral immunology, Bethesda. 173-183.
 
16. Vaghasiya, J., Bhalodia, Y. and Rathod, S. (2009) Drug induced hepatotoxicity: effect of polyherbal formulation. Phcog Mag 5:232-237.
 
17. Uraz, S., Tahan, V., Aygun, C., Eren, F., Unluguzel, G., Yuksel, M., Senturk, O., Avsar, E., Haklar, G., Celikel, C., Hulagu, S. and Tozun, N. (2008) Role of ursodeoxycholic acid in prevention of methotrexate induced liver toxicity. Dig Dis Sci. 53: 1071-1077.
http://dx.doi.org/10.1007/s10620-007-9949-3
PMid:17934844
 
18. Coles, E. H. (1986) Veterinary clinical pathology. 4th edition (ed. E. H. Coles) W. B. Saunders company, Philadelphia. p10-42.
 
19. Al-motabagani, M. A. (2006) Histological and histo- chemical studies on the effects of methotrexate on the liver of adult male albino rat. Int. J. Morphol. 24(3): 417-422.
http://dx.doi.org/10.4067/S0717-95022006000400020
 
20. Asci, H., Ozer, M. K., Calapoglu, M., Savran, M., Oncu, M., Yesilot, S., Candan, I. A., Kulac, E. and Cicek, E. (2011) Effects of misoprostol on methotrexate induced hepatic and renal damages. J. Biol. Life. Sci. 2(1): 32-37.
 
21. Chelab, K. G. and Majeed, S. K. (2009) Methotrexate induced histopathological changes in the kidneys of mice. Iraqi J. Vet. Sci. 23: 219-222.
 
22. Hanley M. J. (1980) Isolated nephron segments in a rabbit model of ischemic acute renal failure. Am. J. Physiol. 239: 17-13.
 
23. Arash, K., Novin, M. G., Khaki, A. A., Nouri, M. and Ozanci, C. C. (2007) Effect of growth hormone on recovery from testicular damage induced by methotrexate in rat. Reprod Toxicol. 01/2008; 26(1):65-65.
 
24. Khulood, W., Ismaeel A. H. and Abdulatif, A. W. (2010) Effects of aqueous extract of salvia on some parameters of sperms and histopathological changes in testes of mice treated with methotrexate. J. Biotechnol. Res. Center. 4(2): 3-10.
 
25. Safavi, S. E., Khayat, N. M. H., Khaki, A. and Serati N. H. (2010) Effect of growth hormone on histomorphometerical parameters of testis after methotrexate administration in rat. Vet. Res. 6(1): 23-29.