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Research
(Published
online: 29-06-2014)
1 5.
A preliminary study on serum liver function indices of
Diethylnitrosamine induced hepatocarcinogenesis and
chemoprotective potential of Eclipta alba in male Wistar rats
- R. Anoopraj, S. Hemalatha and C. Balachandran
Veterinary World, 7(6): 439-442
doi:
10.14202/vetworld.2014.439-442
R. Anoopraj: Department of Pathology, Madras Veterinary
College, Tamil Nadu Veterinary and Animal Sciences University (TANUVAS),
Chennai- 600 007, Tamil Nadu, India; Present address: Division of
Pathology, Indian Veterinary Research Institute, Izatnagar -
243122, India; dranooprajvet@gmail.com
S. Hemalatha: Department of Pathology, Madras Veterinary
College, Tamil Nadu Veterinary and Animal Sciences University (TANUVAS),
Chennai- 600 007, Tamil Nadu, India; hemacul@yahoo.com
C. Balachandran: Department of Pathology, Madras Veterinary
College, Tamil Nadu Veterinary and Animal Sciences University (TANUVAS),
Chennai- 600 007, Tamil Nadu, India; cbalachandran@yahoo.com
Received: 11-04-2014, Revised: 26-05-2014, Accepted: 29-05-2014,
Published online: 29-06-2014
Corresponding author: R. Anoopraj, email:
dranooprajvet@gmail.com. Present address: Division of Pathology,
Indian Veterinary Research Institute, Izatnagar - 243122, India.
email: dranooprajvet@gmail.com
Abstract
Aim: To study the effect of
E. alba on liver function in experimental hepatocarcinogenesis in
Wistar rats.
Materials and Methods: The study was designed to identify
the protective effect of Eclipta alba in experimental
diethylnitrosamine (DEN) induced hepatocarcinogenesis in rats.
Sixty four male Wistar albino rats were randomly allotted to four
groups of 16 rats each. DEN (0.01%, v/v) was given in drinking
water ad libitum and E. alba (50 mg/kg BW/day) was administered
per os either alone or in combination for 120 days. Serum protein,
albumin and liver functional status enzyme profiles were studied.
Results: Administration of DEN resulted in reduction in the
body weights and DEN in combination with E. alba caused poor
weight gain in male Wistar albino rats. Concurrent administration
of E. alba with DEN significantly alleviated the effects of DEN on
serum protein and albumin, while a partial protective effect was
observed for other biochemical values and body weight.
Conclusion: The designed study could establish the partial
protective effect of E. alba in experimentally induced
hepatocarcinogenesis in rats.
Keywords: albumin, diethylnitrosamine, E. alba,
hepatocarcinogenesis, liver functional status enzymes, serum
protein, Wistar albino rats.
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