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Research
(Published
online: 20-03-2014)
10.
Effect of Imidocarb dipropionate on the
immune response to Foot and Mouth Disease vaccine in healthy and
anaplasmosis-infected calves
- N. A. Afifi, I. M.
Shihata, H. Y. El-zorba and I. M. Ismail
Veterinary World, 7(3): 162-167
doi:
10.14202/vetworld.2014.162-167
Abstract
Aim: This work was performed
to investigate the effect of a potent anti-protozoan drug,
Imidocarb on the cell mediated and humoral immune response to foot
and mouth disease vaccine (FMDV, O1 strain) in normal and
Anaplasmosis-infected calves.
Materials and Methods: A total of 55 male mixed bred calves
were used and divided into two main groups of 25 calves each. The
first group was healthy and the second was Anaplasma - infected
calves. FMDV was administered in both groups. Calves of the first
and second groups were subdivided into equal five subgroups of 5
calves each. The first subgroup was vaccinated control. The
treated subgroups were each given 3 mg / kg body weight Imidocarb
dipropionate in a single intramuscular dose at one week before
vaccination, at time of vaccination, one week and two weeks post
vaccination with FMDV (O1), respectively. The cellular immune
response in the different groups was evaluated weekly, however
antibody titers were measured by ELISA and serum neutralization
test
Results: Imidocarb increased rate of erythrocyte rosette
forming lymphocytes when it was administered one week before
vaccination, at time of vaccination and one week post vaccination.
Imidocarb increased antibody titre of FMDV in both normal and
anaplasmosis-infected calves. The protection rate due to challenge
with virulent FMDV was high in treated calves as compared with the
vaccinated control.
Conclusion: The best immunopotentiating effect of Imidocarb
is achieved by dosing one week before vaccinating calves with FMD
vaccine.
Key words: anaplasmosis, calves, imidocarb, immune
response, Foot and Mouth Disease, vaccine.
References
1. Aubry, P. and Geale, D.W. (2011) A review of bovine
anaplasmosis. Transbound Emerg Dis., 58: 1–30.
http://dx.doi.org/10.1111/j.1865-1682.2010.01173.x
PMid:21040509 |
|
|
|
2. Khan, M. Q., Zahoor, A., Jahangir, M. and Mirza, M. A.
(2004) Prevalence of blood parasites in cattle and buffaloes.
Pak. Vet. J., 24:193-19. |
|
|
|
3. Afridi, Z.K., Ahmed, I., Khattak, G.Z., Habib Ullah, Q. and
Jammil M. (2005) Incidence of anaplasmosis, babesiosis and
theileriosis in dairy cattle in Peshawar. Sarhad. J. Agric.,
21: 311-316. |
|
|
|
4. Alejandro Cabezas-Cruz, Lygia M. F. Passos, Katarzyna Lis,
Rachel Kenneil, James J. Valde´ s,Joana Ferrolho, Miray Tonk,
Anna E. Pohl, Libor Grubhoffer, Erich Zweygarth, Varda Shkap,
Mucio F. B. Ribeiro, Agustı´n Estrada-Pen˜ a, Katherine M.
Kocan, Jose´ de la Fuente (2013) Functional and immunological
relevance of Anaplasma marginale major surface protein 1a
sequence and structural analysis. PLoS One, 8(6): e 65243. |
|
|
5. Kocan, K.M., de la Fuente, J., Guglielmone, A.A. and
Melendez, R.D. (2003) Antigens and alternatives for control of
Anaplasma marginale infection in cattle. Clin Microbiol Rev.,
16: 698–712.
http://dx.doi.org/10.1128/CMR.16.4.698-712.2003
PMid:14557295 PMCid:PMC207124 |
|
|
6. Kocan, K.M., de la Fuente, J., Blouin, E.F. and Garcia-
Garcia, J.C. (2004) Anaplasma marginale (Rickettsiales:
Anaplasmataceae): recent advances in defining hostpatho- gen
adaptations of a tick-borne rickettsia. Vet. Parasitol., 129
Suppl: S285–300.
http://dx.doi.org/10.1017/S0031182003004700 |
|
|
|
7. Dulmer, J.S., Barbet, A.F., Bekker, C.P., Dasch, G. A.,
Palmer, G.H., Ray, C.H., Rikihisa and Rurangirwa, F.R., (2001)
Recognition of genera in the families Rickettsiaceae and
Anaplasmataceae in order Rickesttsiales. Int. J. Syst. Evol.
Microbiol., 51: 2145- 2165. |
|
|
8. Kocan, K.M., de la Fuente, J., Blouin, E.F., Coetzee, J.F.
and Ewing, S.A. (2010) The natural history of Anaplasma
marginale. Vet Parasitol., 167(2-4):95-107.
http://dx.doi.org/10.1016/j.vetpar.2009.09.012
PMid:19811876 |
|
|
9. Aboulaila, M., Nakamura, K., Govind, Y., Yokoyama, N. and
Igarashi, I. (2010) Evaluation of the in vitro growth-
inhibitory effect of epoxomicin on Babesia parasites. Vet.
Parasitol., 167: 19–27.
http://dx.doi.org/10.1016/j.vetpar.2009.09.049
PMid:19896277 |
|
|
10. Suarez, C.E. and Noh, S. (2011) Emerging perspectives in
the research of bovine babesiosis and anaplasmosis. Vet.
Parasitol. 180(1-2): 109–125.
http://dx.doi.org/10.1016/j.vetpar.2011.05.032
PMid:21684084 |
|
|
|
11. Marta G. Silva, Ana, Domingos, M. Alexandra Esteves, Maria
E.M. Cruz and Carlos E. Suarez (2013) Evaluation of the
growth-inhibitory effect of trifluralin analogues on in vitro
cultured Babesia bovis parasites. Int. J. Parasitol: Drugs and
Drug Resistance 3: 59–68. |
|
|
12. Adams, L.G. and Corrier, D.E. (1980) A study of the
toxicity of Imidocarb in cattle. Res.Vet. Sci., 28(2): 172-
177.
PMid:7414062 |
|
|
13. Abdullah, A.S. and Baggot, J.D. (1986) Influence of
induced disease states on the disposition kinetics of
Imidocarb in goats. J. Vet. Pharmacol. Therapeut., 9(2):
192-197.
http://dx.doi.org/10.1111/j.1365-2885.1986.tb00029.x |
|
|
|
14. Coetzee, J.F., Apley, M.D. and Kocan, K.M., (2006)
Comparison of the efficacy of enrofloxacin, Imidocarb and
oxytetracycline for clearance of persistent Anaplasma
marginale infections in cattle. Vet. Therapeut, 7: 347-360. |
|
|
15. Coetzee, J.F., Kocan, K.M., Higgins, J.J., Apley, M.D. and
Jones, D.E. (2009) Ultrastructural and fluorochromatic changes
of Anaplasma marginale exposed to oxytetracycline, Imidocarb
and enrofloxacin in short-term erythrocyte cultures. Vet
Microbiol. 136(1-2):45-53.
http://dx.doi.org/10.1016/j.vetmic.2008.10.014
PMid:19054634 |
|
|
|
16. Akhter, N., Lal, C., Gadahi, J.A., Mirbahar, K.B. and
Memon, M.I.(2010) Efficacy of various Antiprotozoal drugs on
bovine babesiosis, Anaplasmosis and theileriosis. Vet. World.
3:272-274. |
|
|
|
17. Atif, F.A., Khan, M.S., Khan, M.A., Ashraf, M. and Avais,
M. (2012) Chemotherapeutic efficacy of oxytetracycline,
enrofloxacin and Imidocarb for the elimination of persistent
Anaplasma marginale infection in naturally infected Sahiwal
cattle. Pakistan J. Zool., 44(2):449-456. |
|
|
|
18. Katayama, T., Hayashi, Y., Nagahira, K., Konishi, K.,
Yamaichi, K. and Oikawa, S.(2003) Imidocarb, a potent anti-
protozoan drug, up-regulates interleukin-10 production by
murine macrophages. Biochem Biophys Res Commun., 19;
309(2):414-8. |
|
|
|
19. Monika, Sawhney, S.M.S., Sanyal, A., Venkataramanan, R.,
Ramneek, Randhawa, S.S. and Oberoi, M.S.(2004):
Characterization of humoral and cell mediated immune response
following aluminium hydroxide gel adjuvanted foot and mouth
disease vaccine in cattle. Indian J. Anim. Sci., 74(7) p.
693-696. |
|
|
|
20. Kaupp, E., Pobst, R. and Trepel F. (1977) Rosette
formation of pig peripheral blood lymphocytes with sheep red
blood cells. Zeitschrift fur immune- tatsforschung, 152:438. |
|
|
21. Pega, J., Bucafusco, D., Di Giacomo S., Schammas J. M.,
Malacari D., Capozzo A., Arzt V. and Pérez-Filgueira M. (2013)
Early Adaptive Immune Responses in the Respiratory Tract of
Foot-and Mouth Disease Virus-Infected Cattle. Virol. J.,
87(5): 2489–2495.
http://dx.doi.org/10.1128/JVI.02879-12
PMid:23255811 PMCid:PMC3571376 |
|
|
22. Ma, L.N., Zhang, J., Chen, H.T., Zhou, J.H., Ding, Y.Z.
and Liu, Y.S. (2011) An overview on ELISA techniques for FMD.
Virol. J. 8:419.
http://dx.doi.org/10.1186/1743-422X-8-419
PMid:21888667 PMCid:PMC3180423 |
|
|
|
23. Zeynep Sanem and Ulvi Reha Fidanc (2009) Serum protein
electrophoretic distribution of calves infected with and
vaccinated against foot and mouth disease. Ankara Üniv Vet Fak
Derg, 56: 13-18. |
|
|
|
24. Yao-Zhong, Ding., Hao-Tai, Chen., Jie, Zhang., Jian-Hua,
Zhou., Li-Na, Ma., Liang, Zhang., Yuanxin, Gu. and Yong- Sheng,
Liu (2013) An overview of control strategy and diagnostic
technology for foot-and-mouth disease in China. Virol J., 10:
78. 25. |
|
|
|
25. Daoud, A., Omar, A., EL-Bakry, M., Metwally, N., EL-
Mikkawi, M. and EL-Kilany, S.(1988) Strains of Foot and Mouth
Disease Virus recovered from 1987 outbreak in Egypt. J. Egypt
Vet. Med. Assoc., 48(1): 63-71. |
|
|
26. Bengelsdorff, H.J. (1989) Testing the efficacy of Foot and
Mouth Disease Vaccines: relationships between test infection
results and corresponding neutralization titres of vaccinate
cattle. Berl. Munch. tierarztl. Wschr., 102(6): 193- 198.
PMid:2548473 |
|
|
|
27. Bernard, Y., Berain, J.P., Lescure, G., Levasseur, G. and
Schmitt, H.(1981) Clinical trials of a new piroplasmicide:
Imidocarb. Bull.Mens. Soci. Vet. Prati. France, 65(2):
109-115. |
|
|
28. Ada, G. (1990) The immunological principles of
vaccination. Lancet, 335: 523-526.
http://dx.doi.org/10.1016/0140-6736(90)90748-T |
|
