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Research
(Published
online: 13-09-2014)
9. Clinical evaluation of
total intravenous anaesthesia using xylazine or dexmedetomidine
with propofol in surgical management of canine patients -
Biswadeep Jena, Jayakrushna Das, Indramani Nath, Kautuk Kumar
Sardar, Abhishek Sahoo, Sasanka Sekhar Beura and Abhishek Painuli
Veterinary World, 7(9): 671-680
doi:
10.14202/vetworld.2014.671-680
Biswadeep Jena:
Department of Veterinary Surgery & Radiology, College of
Veterinary Science & Animal Husbandry, Orissa University of
Agriculture and Technology, Bhubaneswar, Odisha, India;
biswadeep44@gmail.com
Jayakrushna Das:
Department of Veterinary Surgery & Radiology, College of
Veterinary Science & Animal Husbandry, Orissa University of
Agriculture and Technology, Bhubaneswar, Odisha, India;
drjohndasjajpur@yahoo.co.in
Indramani Nath:
Department of Veterinary Surgery & Radiology, College of
Veterinary Science & Animal Husbandry, Orissa University of
Agriculture and Technology, Bhubaneswar, Odisha, India; indravet@yahoo.co.in
Kautuk Kumar Sardar:
Department of Veterinary Pharmacology & Toxicology, College of
Veterinary Science & Animal Husbandry, Orissa University of
Agriculture and Technology, Bhubaneswar, Odisha, India; kksardar@gmail.com
Abhishek Sahoo:
Department of Animal Nutrition, College of Veterinary Science &
Animal Husbandry, Orissa University of Agriculture and Technology,
Bhubaneswar, Odisha, India; draviseq@gmail.com
Sasanka Sekhar Beura:
Department of Livestock Production & Management, College of
Veterinary Science & Animal Husbandry, Orissa University of
Agriculture and Technology, Bhubaneswar, Odisha, India;
sasankavet41@gmail.com
Abhishek Painuli: Department of Veterinary Surgery &
Radiology, G. B. Pant University of Agriculture & Technology,
Pantnagar (Usham Singh Nagar), Uttarakhand, India;
painuliabhishek177@gmail.com
Received: 08-05-2014, Revised: 22-07-2014, Accepted: 27-07-2014,
Published online: 13-09-2014
Corresponding author:
Biswadeep Jena, email: biswadeep44@gmail.com
Abstract
Aim:
The aim was to evaluate and compare the clinico-physiological,
hemodynamic and hematobiochemical effects in response to different
total intravenous anaesthesia techniques using xylazine or
dexmedetomidine with propofol in canine patients.
Materials and Methods: Under a prospective randomized blinded
clinical study, 12 apparently healthy adult dogs (14.27±3.2 kg)
divided into two groups (n=6). Animals were administered with
xylazine (0.5 mg/kg body weight IV) in X group or, dexmedetomidine
(10 μg/kg
body weight IV) in D group and propofol (as IV bolus till the
induction and continuous IV infusion for maintenance). Clinical
reflexes, physiological, hemodynamic parameters, were recorded at
5-min intervals. Blood was collected at zero, 30 and 60 min after
initial injection for hematobiochemical evaluation. Statistical
analysis was performed using analysis of variance, Duncan’s
multiple range tests, paired - t-test and Kruskal–Wallis one-way
test.
Results: Animals showed quicker attenuation
of all clinical reflexes in group D. Induction doses of propofol
were 3.17±0.21 and 2.72±0.15 mg/kg and rate of infusion of
propofol for maintenance of anaesthesia were 0.33±0.02 mg/kg/min
and 0.35±0.02 mg/kg/min respectively in group X and D. Recovery
was quicker in group D. There were no significant statistical
differences in physiological, hemodynamic and hematobiochemical
parameters in both the groups. There were no adverse effects after
recovery.
Conclusion: Both anesthetic protocols provided satisfactory
immobilization, but dexmedetomidine-propofol combination may be
preferred owing to slightly better degree of basal anaesthesia,
lesser doses of propofol required for induction and maintenance of
anaesthesia along with a lesser degree of respiratory depression.
However, there was no clear preference for either of the protocol,
and both appear suitable for canines.
Keywords: alpha2 adrenoreceptor agonist,
canine surgery, dexmedetomidine, propofol, total intravenous
anaesthesia, xylazine.
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