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Research (Published online: 07-08-2015)

1.  Effect of Phyllanthus amarus on serum biochemical changes in azaserine induced pancreatic cancer in Wistar rats - Ankit S. Prajapati, Sunant K. Raval, Suprita Sinha, Tapan N. Varia and Parimal H. Mashiyava

Veterinary World, 8(8): 937-940

 

 

   doi: 10.14202/vetworld.2015.937-940

 

Ankit S. Prajapati: Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat, India; ankitprjpt1@gmail.com

Sunant K. Raval: Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat, India; skraval23@rediffmail.com

Suprita Sinha: Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat, India; drsupritasinha@gmail.com

Tapan N. Varia: Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat, India; dr.tapanvaria@gmail.com

Parimal H. Mashiyava: Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat, India; parimal211289@gmail.com

 

Received: 19-05-2015, Revised: 04-07-2015, Accepted: 09-07-2015, Published online: 07-08-2015

 

Corresponding author: Ankit S. Prajapati, e-mail: ankitprjpt1@gmail.com


Citation: Prajapati AS, Raval SK, Sinha S, Varia TN, Mashiyava PH (2015) Effect of Phyllanthus amarus on serum biochemical changes in azaserine induced pancreatic cancer in wistar rats, Veterinary World 8(8): 937-940.



Aim: The present study was performed to investigate the effect of Phyllanthus amarus extracts on serum biochemical changes in azaserine induced pancreatic cancer in Wistar rats.

Materials and Methods: Pancreatic cancer was developed in Wistar rats by intraperitoneal administration of azaserine (cancer inducer) for 21 days at the concentration of 5 mg/kg body weight. Aqueous and alcoholic extracts were given to rats of different groups as per protocol.

Results: The results data revealed that oral administration of P. amarus extracts had a significant change in pancreatic amylase, lipase, aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase activity.

Conclusion: We concluded that extract of P. amarus possessed chemoprotective activity against azaserine induced pancreatic cancer in Wistar rats.

Keywords: azaserine, pancreatic cancer, Phyllanthus amarus, serum biochemistry, Wistar rat.



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