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cited.
R esearch
(Published online:
07-08-2015)
1.
Effect
of Phyllanthus amarus on serum biochemical changes in
azaserine induced pancreatic cancer in Wistar rats
-
Ankit
S. Prajapati, Sunant K. Raval, Suprita Sinha, Tapan N. Varia and
Parimal H. Mashiyava
Veterinary World, 8(8): 937-940
doi:
10.14202/vetworld.2015.937-940
Ankit S. Prajapati:
Department of Veterinary Medicine, College of Veterinary Science
and Animal Husbandry, Anand Agricultural University, Anand,
Gujarat, India;
ankitprjpt1@gmail.com
Sunant K. Raval:
Department of Veterinary Medicine, College of Veterinary Science
and Animal Husbandry, Anand Agricultural University, Anand,
Gujarat, India;
skraval23@rediffmail.com
Suprita Sinha:
Department of Veterinary Pharmacology and Toxicology, College of
Veterinary Science and Animal Husbandry, Anand Agricultural
University, Anand, Gujarat, India;
drsupritasinha@gmail.com
Tapan N. Varia:
Department of Veterinary Medicine, College of Veterinary Science
and Animal Husbandry, Anand Agricultural University, Anand,
Gujarat, India;
dr.tapanvaria@gmail.com
Parimal H. Mashiyava: Department of
Veterinary Medicine, College of Veterinary Science and Animal
Husbandry, Anand Agricultural University, Anand, Gujarat, India;
parimal211289@gmail.com
Received:
19-05-2015, Revised: 04-07-2015, Accepted: 09-07-2015, Published
online: 07-08-2015
Corresponding author:
Ankit
S. Prajapati, e-mail: ankitprjpt1@gmail.com
Citation:
Prajapati AS, Raval SK, Sinha S, Varia TN, Mashiyava PH (2015)
Effect of Phyllanthus amarus on serum biochemical changes
in azaserine induced pancreatic cancer in wistar rats,
Veterinary World 8(8): 937-940.
Abstract
Aim: The present study was
performed to investigate the effect of Phyllanthus amarus
extracts on serum biochemical changes in azaserine induced
pancreatic cancer in Wistar rats.
Materials and Methods: Pancreatic cancer was developed in
Wistar rats by intraperitoneal administration of azaserine (cancer
inducer) for 21 days at the concentration of 5 mg/kg body weight.
Aqueous and alcoholic extracts were given to rats of different
groups as per protocol.
Results: The results data revealed that oral administration of
P. amarus extracts had a significant change in pancreatic
amylase, lipase, aspartate aminotransferase, alanine
aminotransferase, and alkaline phosphatase activity.
Conclusion: We concluded that extract of P. amarus
possessed chemoprotective activity against azaserine induced
pancreatic cancer in Wistar rats.
Keywords: azaserine, pancreatic cancer, Phyllanthus amarus,
serum biochemistry, Wistar rat.
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