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R esearch
(Published online: 07-03-2015)
5.
The effect of gabapentin and pregabalin on
intestinal incision wound healing in rabbits - M.
Korkmaz, T. B. Saritas, A. Sevimli, Z. K. Saritas and B. Elitok
Veterinary World, 8(3): 279-283
doi:
10.14202/vetworld.2015.279-283
M.
Korkmaz:
Department of Surgery, Faculty of Veterinary Medicine, Afyon
Kocatepe University, 03200, Afyonkarahisar, Turkey; musakorkmaz@aku.edu.tr
T. B.
Saritas:
Department of Anaesthesiology and Reanimation, Meram Medical
School, Necmettin Erbakan University, 42080, Konya, Turkey;
tsaritas@konya.edu.tr
A.
Sevimli:
Department of Pathology, Faculty of Veterinary Medicine, Afyon
Kocatepe University, 03200, Afyonkarahisar, Turkey; alpers@aku.edu.tr
Z. K.
Saritas:
Department of Surgery, Faculty of Veterinary Medicine, Afyon
Kocatepe University, 03200, Afyonkarahisar, Turkey; zksaritas@hotmail.com
B.
Elitok: Department of Internal Medicine, Faculty of Veterinary
Medicine, Afyon Kocatepe University, 03200, Afyonkarahisar,
Turkey;
belitok@yahoo.com
Received: 18-11-2014, Revised: 15-01-2015, Accepted: 25-01-2015,
Published online: 07-03-2015
Corresponding author:
M. Korkmaz, e-mail: musakorkmaz@aku.edu.tr
Citation:
Korkmaz M, Saritas TB,
Sevimli A, Saritas ZK, Elitok B (2015) The effect of gabapentin
and pregabalin on intestinal incision wound healing in rabbits,
Veterinary World 8(3):279-283.
Abstract
Aim:
To evaluate the macroscopic and
histologic effects of pregabalin (PG) gabapentin (GB) on
longitudinal intestinal wound healing in New Zealand rabbits.
Materials and Methods: The animals were divided into three
groups randomly; the control group (n=6), PG group (n=6) and GB
group (n=6). All animals were premedicated with xylazine HCI, 5
mg/kg i.m. and general anaesthesia was performed by ketamine HCI
50 mg/kg i.m injection. A 4 cm incision in the caecum through
median laparotomy was achieved under aseptic surgery. Intestinal
wound was closed with double-sutured. All animals were received
parenteral antibiotic treatment for 5 days. PG and GB groups were
treated by PG (30 mg/kg, oral, daily) and GB (30 mg/kg, oral,
daily) for 10 days respectively. Control group did not receive any
treatment. The animals were euthanized on day 10 and the caecum
was examined by laparotomy. Adhesion formation was observed, and
tissue samples were taken from suture lines for histologic
examination. Cellular infiltration (polymorphonuclear white blood
cells and mononuclear cells), accumulation of connective tissue,
vascularization and extent of necrosis were evaluated and scored
separately for each of mucosal, submucosal, muscular and serosal
layers of caecum.
Results: Adhesions were more severe in the GB group compared
to other groups. No statistically significant differences were
detected among the three groups about the wound healing.
Conclusion: It was suggested that the use of
gabapentinoids had no significant effect on wound healing in
patients undergoing gastrointestinal surgery and further studies
with treatment periods longer than 10 days are needed.
Keywords: gabapentin, intestinal incisional
wound, pregabalin, rabbit.
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