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R esearch
(Published online:
06-05-2015)
5.
Acute
and subchronic toxicity assessment model of Ferula assa-foetida
gum in rodents
-
Ayman
Goudah, Khaled Abo-El-Sooud and Manal A. Yousef
Veterinary World, 8(5): 584-589
doi:
10.14202/vetworld.2015.584-589
Ayman Goudah:
Department of Pharmacology, Faculty of Veterinary Medicine, Cairo
University, Giza, Egypt;
aymangouda@yahoo.com
Khaled Abdo-El-Sooud:
Department of Pharmacology, Faculty of Veterinary Medicine, Cairo
University, Giza, Egypt;
kasooud@yahoo.com
Manal A. Yousef: Department of
Pharmacology, Faculty of Veterinary Medicine, Cairo University,
Giza, Egypt;
nourelhaia1234@yahoo.com
Received:
11-12-2014, Revised: 01-04-2015, Accepted: 10-04-2015, Published
online: 06-05-2015
Corresponding author:
Ayman
Goudah, e-mail address: aymangouda@yahoo.com
Citation:
Goudah
A, Abo-EL-Sooud K, Yousef MA (2015) Acute and subchronic toxicity
assessment model of Ferula assa-foetida gum in rodents,
Veterinary World 8(5);584-589.
Abstract
Aim: The present study was
performed to investigate acute and subchronic oral toxicity of
Ferula assa-foetida gum (28 days) in Sprague Dawley rats.
Materials and Methods: Acute oral administration of F.
assa-foetida was done as a single bolus dose up to 5 g/kg
in mice and subchronic toxicity study for 28 days was done by oral
administration at doses of 0 (control) and 250 mg/kg in Sprague
Dawley rats.
Results: The obtained data revealed that oral administration
of F. assa-foetida extract in rats for 28 successive
days had no significant changes on body weight, body weight gain,
the hematological parameters in rats all over the period of the
experiment, and there are no significant increases in the activity
of aspartate aminotransferase, alanine aminotransferase, alkaline
phosphatase, creatinine and urea. Liver of treated rats showed
mild changes as thrombosis and sinusoidal leukocytosis. It also
showed portal infiltration with inflammatory cells, while kidney
of treated rat showed an atrophy of glomerular tuft, thickening of
parietal layer of Bowman capsule, and focal tubular necrosis. It
also showed dilatation and congestion of renal blood vessels.
Conclusion: We concluded that F. assa-foetida
gum had broad safety and little toxicity for short term use in
dose of 250 mg/kg.
Keywords: F. assa-foetida, histopathology, rats,
serum enzymatic activity, subchronic toxicity.
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