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R eview
(Published online:
14-05-2015)
6.
Role of parasitic vaccines in integrated
control of parasitic diseases in livestock - Neelu
Sharma, Veer Singh and K. P. Shyma
Veterinary World, 8(5): 590-598
doi:
10.14202/vetworld.2015.590-598
Neelu
Sharma:
Department of Veterinary Parasitology, College of Veterinary
Science and Animal Husbandry, Sardarkrushinagar
Dantiwada
Agricultural University, Sardarkrushinagar - 385 506, Gujarat,
India; neelusharmans88@gmail.com
Veer
Singh:
Department of Veterinary Parasitology, College of Veterinary
Science and Animal Husbandry, Sardarkrushinagar
Dantiwada
Agricultural University, Sardarkrushinagar - 385 506, Gujarat,
India; veersinghgau@gmail.com
K. P.
Shyma: Department of Veterinary Parasitology, College of
Veterinary Science and Animal Husbandry, Sardarkrushinagar
Dantiwada
Agricultural University, Sardarkrushinagar - 385 506, Gujarat,
India;
dr.shymakpvet@gmail.com
Received:
28-01-2015, Revised: 26-03-2015, Accepted: 31-03-2015, Published
online: 14-05-2015
Corresponding author:
K. P. Shyma, e-mail: dr.shymakpvet@gmail.com
Citation:
Sharma N, Singh V,
Shyma KP (2015) Role of parasitic vaccines in integrated control
of parasitic diseases in livestock, Veterinary World 8(5):590-598.
Abstract
Parasitic infections adversely affect animal’s health and threaten
profitable animal production, thus affecting the economy of our
country. These infections also play a major role in the spread of
zoonotic diseases. Parasitic infections cause severe morbidity and
mortality in animals especially those affecting the
gastrointestinal system and thus affect the economy of livestock
owner by decreasing the ability of the farmer to produce
economically useful animal products. Due to all these reasons
proper control of parasitic infection is critically important for
sustained animal production. The most common and regularly used
method to control parasitic infection is chemotherapy, which is
very effective but has several disadvantages like drug resistance
and drug residues. Integrated approaches to control parasitic
infections should be formulated including grazing management,
biological control, genetic resistance of hosts, and parasitic
vaccines. India ranks first in cattle and buffalo population, but
the majority of livestock owners have fewer herds, so other
measures like grazing management, biological control, genetic
resistance of hosts are not much practical to use. The most
sustainable and economical approach to control parasitic infection
in our country is to vaccinate animals, although vaccines increase
the initial cost, but the immunity offered by the vaccine are long
lived. Thus, vaccination of animals for various clinical, chronic,
subclinical parasitic infections will be a cheaper and effective
alternative to control parasitic infection for long time and
improve animal production.
Keywords: drug resistance, integrated
control measures, parasitic infections, parasitic vaccines.
References
1. Bandopadhyay, S., Mandal, S., Datta, K.K., Devi, P., De,
S., Bera, A.K. and Bhattacharya, D. (2010) Economic analysis
of risk of gastrointestinal parasitic infections in cattle in
North Eastern States of India. Trop. Anim. Health Prod.,
42(7): 1481-1486.
http://dx.doi.org/10.1007/s11250-010-9582-6
PMid:20411327 |
|
|
|
2. Ramaswamy, K. (2014) Role of parasite vaccines in sustained
animal health and production. Proceeding. XXIVth National
Congress of Veterinary Parasitology held at Trichur (5-7 Feb.
2014), p22-30. |
|
|
3. Karim, S.A., Porwal, K., Kumar, S. and Singh, V.K. (2007)
Carcass traits of Kheri lambs maintained on different system
of feeding management. Meat Sci., 76(3): 395-401.
http://dx.doi.org/10.1016/j.meatsci.2006.06.008
PMid:22060980 |
|
|
4. Shalaby, H.A. (2013) Anthelmintics resistance; How to
overcome it? Iran. J. Parasitol., 8(1): 18-32.
PMid:23682256 PMCid:PMC3655236 |
|
|
6. Singh, D., Swarnkar, C.P., Khan, F.A., Srivastava, C.P. and
Baghwan P.S.K. (1997) Epidemiology of ovine gastrointestinal
nematodes in an organized farm in Rajasthan India. Small
Rumin. Res., 26(1-2): 31-37.
http://dx.doi.org/10.1016/S0921-4488(96)00988-1 |
|
|
7. Koolsterman, A., Parmentier, H.K. and Ploeger, H.W. (1992)
Breeding cattle and sheep for resistance to gastrointestinal
nematodes. Parasitol. Today, 8(10): 330-335.
http://dx.doi.org/10.1016/0169-4758(92)90066-B |
|
|
8. Ibeli, A.M., Riberio, A.R., Giglioti, R., Regitano, L.C.,
Alencar, M.M., Chagas, A.C. and Oliveria, M.C. (2012)
Resistance of cattle of various genetic groups to the tick
Riphicephalus microplus and the relationship with coat traits.
Vet. Parasitol., 186(3-4): 425-430.
http://dx.doi.org/10.1016/j.vetpar.2011.11.019
PMid:22115946 |
|
|
9. Larsen, M. (1999) Biological control of helminths. Int. J.
Parasitol., 29(1): 139-146.
http://dx.doi.org/10.1016/S0020-7519(98)00185-4 |
|
|
10. Sanyal, P.K., Chauhan, J.B. and Mukhopadhyaya, P.N. (2005)
Implications of fungicidal effects of benzimidazole compounds
on Duddingtonia flagrans in integrated nematode parasite
management in livestock. Vet. Res. Commun., 28(5): 375-385.
http://dx.doi.org/10.1023/B:VERC.0000034997.50332.77 |
|
|
11. Sutherland, I.A. and Leathwick, D.M. (2011) Anthelmintic
resistance in nematode parasites of cattle: A global issue?
Trends Parasitol., 27(4): 176-181.
http://dx.doi.org/10.1016/j.pt.2010.11.008
PMid:21168366 |
|
|
|
12. Lightowlers, M.W. and Heath, D.D. (2003) Immunity and
vaccine control of Echinococcus granulosus infection in animal
intermediate hosts. Parasitologia, 46(1): 27-31. |
|
|
13. Waller, P.J. (2006) From discovery to development; Current
industry perspectives for the development of novel methods of
helminth control in livestock. Vet. Parasitol., 139(1-3):
1-14.
http://dx.doi.org/10.1016/j.vetpar.2006.02.036
PMid:16675128 |
|
|
14. Innes, E.A., Bartley, P.M., Rocchi, M., Benavidas-Silvan,
J., Burrells, A., Hotchkiss, E., Chianini, F., Canton, G. and
Katzer, F. (2011) Developing vaccines to control protozoan
parasites in ruminants: Dead or alive. Vet. Parasitol.,
180(1-2): 155-163.
http://dx.doi.org/10.1016/j.vetpar.2011.05.036
PMid:21680094 |
|
|
15. Meeusen, E.N.T., Walker, J., Peters, A., Pastoret, P. and
Jungersen, G. (2007) Current status of veterinary vaccines.
Clin. Microbiol. Rev., 20(3): 489-510.
http://dx.doi.org/10.1128/CMR.00005-07
PMid:17630337 PMCid:PMC1932753 |
|
|
|
16. Kumar, T., Tufani, N.A., Prasad, A., Arora, N. and Rajora,
V.S. (2013) Veterinary parasitic vaccines – A current
scenario. Int. J. Livest. Res. 3(1): 5-11. |
|
|
|
17. Garg, R., Kundu, K., Kumar, S. and Banerjee, P.S. (2013)
Current trends and future prospects of vaccine development
against poultry coccidiosis. Molecular Biological Approaches
for Diagnosis and Control of Parasitic Diseases. Indian
Veterinary Research Institute, Izatnagar, U.P., India. p182. |
|
|
|
18. Saravanan, B.C., Ray, D.D. and Sankar, M. (2013)
Conventional and molecular vaccine against protozoans
infecting livestock. Molecular Biological Approaches for
Diagnosis and Control of Parasitic Diseases. Indian Veterinary
Research Institute, Izatnagar, U.P., India. p182. |
|
|
19. Mc Keever, D.J., Taracha, E.L., Morrison, W.I., Musoke,
A.J. and Morzaria, S.P. (1999) Protective immune mechanisms
against Theileria parva: Evolution of vaccine development
strategies. Parasitol. Today, 15(7): 263-267.
http://dx.doi.org/10.1016/S0169-4758(99)01465-9 |
|
|
20. Buxton D. (1993) Toxoplasmosis: The first commercial
vaccine. Parasitol. Today, 9(9): 335-337.
http://dx.doi.org/10.1016/0169-4758(93)90236-9 |
|
|
21. Chen, J., Haung, S.Y., Zhou, D.H., Li, Z.Y., Petersen, E.,
Song, H.Q. and Zhu, X.Q. (2013) DNA immunization with
eukaryotic initiation factor – 2alpha of Toxoplasma gondii
induces protective immunity against acute and chronic
toxoplasmosis in mice. Vaccine, 31(52): 6225-6231.
http://dx.doi.org/10.1016/j.vaccine.2013.10.034
PMid:24183979 |
|
|
22. Dalgliesh, R.J., Callow, L.L., Mellors, L.T. and McGregor,
W. (1981) Development of a highly infective Babesia bigemina
vaccine of reduced virulence. Aust. Vet. J., 57(1): 8-11.
http://dx.doi.org/10.1111/j.1751-0813.1981.tb07075.x |
|
|
23. De Waal, D.T. and Combrink, M.P. (2006) Live vaccines
against bovine babesiosis. Vet. Parasitol., 138(1-2): 88-96.
http://dx.doi.org/10.1016/j.vetpar.2006.01.042
PMid:16504404 |
|
|
24. Romero, J.J., Perez, E. and Frankena, K. (2004) Effect of
a killed whole Neospora caninum tachyzoite vaccine on the
crude abortion rate of Costa Rican dairy cows under field
conditions. Vet. Parasitol., 123(3-4): 149-159.
http://dx.doi.org/10.1016/j.vetpar.2004.06.016
PMid:15325041 |
|
|
25. Innes, E.A., Wright, S., Bartley, P., Maley, S.,
Macaldowie, C., Esteban-Redondo, I. and Buxton, D. (2005) The
host-parasite relationship in bovine neosporosis. Vet.
Immunol. Immunopathol., 108(1-2): 29-36.
http://dx.doi.org/10.1016/j.vetimm.2005.07.004
PMid:16098610 |
|
|
26. Olson, M.E., Morck, D.W. and Ceri, H. (2000) Giardia
vaccination. Parasitol. Today, 16(5): 213-217.
http://dx.doi.org/10.1016/S0169-4758(99)01623-3 |
|
|
27. Holroyd, N. and Sanchez – Flores, A. (2012) Producing
parasitic helminth reference and draft genomes at the Wellcome
Trust Sanger Institute. [Review]. Parasite Immunol., 34(2-3):
100-107.
http://dx.doi.org/10.1111/j.1365-3024.2011.01311.x
PMid:21707658 |
|
|
28. Marsh, A.E., Lakritz, J., Johnson, P.J., Miller, M.A.,
Chiang, Y.W. and Chu, H.J. (2004) Evaluation of immune
responses in horses immunized using a killed Sarcocystis
neurona vaccine. Vet. Ther., 5(1): 34-42.
PMid:15150728 |
|
|
29. Baltzell, P., Newton, H. and O'Connor, A.M. (2013) A
critical review and meta-analysis of the efficacy of
whole-cell killed Tritrichomonas foetus vaccines in beef
cattle. J. Vet. Int. Med., 27(4): 760-770.
http://dx.doi.org/10.1111/jvim.12112
PMid:23701212 |
|
|
30. Dalton, J.P., Robinson, M.W., Mulcahy, G., O'Neill, S.M.
and Donnelly, S. (2013) Immunomodulatory molecules of Fasciola
hepatica: Candidates for both vaccine and immunotherapeutic
development. Vet. Parasitol., 195(3-4): 272-285.
http://dx.doi.org/10.1016/j.vetpar.2013.04.008
PMid:23623183 |
|
|
31. Hayashida, K., Abe, T., Weir, W., Nakao, R., Ito, K.,
Kajino, K. and Sugimoto, C. (2013) Whole – Genome sequencing
of Theleria parva strains provides insight into parasite
migration and diversification in the African continent. DNA
Res., 20(3): 209-220.
http://dx.doi.org/10.1093/dnares/dst003
PMid:23404454 PMCid:PMC3686427 |
|
|
32. Menon, R., Gasser, R.B., Mitreva, M. and Ranganathan, S.
(2012) An analysis of transcriptome of Telodorsagia
circumcincta: its biological and biotechnological
implications. BMC Genomics, 13 Suppl 7: 1471-2164.
http://dx.doi.org/10.1186/1471-2164-13-S7-S10
PMid:23282110 PMCid:PMC3521389 |
|
|
33. Nisbet, A.J., McNeilly, T.N., Wildblood, L.A., Morrison,
A.A., Bartely., Y. and Matthews, J.B. (2013) Succesful
immunization against a parasitic nematode by vaccination with
recombinant proteins. Vaccine, 31(37): 4017-4023.
http://dx.doi.org/10.1016/j.vaccine.2013.05.026
PMid:23707168 |
|
|
34. Moreau, Y., Vidor, E., Bissuel, G. and Dubreuil, N. (1989)
Vaccination against canine babesiosis: An overview of field
observations. Trans. R. Soc. Trop. Med. Hyg., 83 Suppl: 95-96.
http://dx.doi.org/10.1016/0035-9203(89)90611-1 |
|
|
35. Schetters, T. (2005) Vaccination against canine
babesiosis. Trends Parasitol., 21(4): 179-184.
http://dx.doi.org/10.1016/j.pt.2005.02.006
PMid:15780840 |
|
|
36. Wallach, M. (1995) Eimeria maxima gametocyte antigens:
Potential use in a subunit maternal vaccine against
coccidiosis in chickens. Vaccine, 13(4): 347-354.
http://dx.doi.org/10.1016/0264-410X(95)98255-9 |
|
|
|
37. EMA. (2011) European Medicines Agency, Scientific
discussion of Cani Leish. Available from:
http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/veterinary/002232/WC500104953.pdf
http://www.ema.europa.eu/docs/en_GB/document_library/EPARpublic_assessment_report/veterinary/002232/WC500104953.pdf
. |
|
|
38. Lemesre, J.L., Holzmuller, P., Goncalves, R.B.,
Bourdoiseau, G., Hugnet, C., Cavaleyra, M. and Papierok, G.
(2007) Long-lasting protection against canine visceral
leishmaniasis using the LiESAp-MDP vaccine in endemic areas of
France: Double-blind randomised efficacy field trial. Vaccine,
25(21): 4223-4234.
http://dx.doi.org/10.1016/j.vaccine.2007.02.083
PMid:17395339 |
|
|
39. Balic, A., Bowles, V.M. and Meeusen, E.N. (2000) The
immunobiology of gastrointestinal nematode infections in
ruminants. Adv. Parasitol., 45: 181-241.
http://dx.doi.org/10.1016/S0065-308X(00)45005-0 |
|
|
40. Maizels, R.M., Balic, A., Gomez-Escobar, N., Nair, M.,
Taylor, M.D. and Allen, J.E. (2004) Helminth parasites –
Masters of regulation. Immunol. Rev., 201: 89-116.
http://dx.doi.org/10.1111/j.0105-2896.2004.00191.x
PMid:15361235 |
|
|
|
41. Raina, O.K., Samanta, S., Jacob, S., Yadav, H.S., Chandra,
S. and Bouri, R.K. (2013) Current status of vaccine
development against Fasciolosis. Molecular Biological
Approaches for Diagnosis and Control of Parasitic Diseases.
Indian Veterinary Research Institute, Izatnagar, U.P., India.
p182. |
|
|
42. Piacenza, L., Acosta, D., Basmadjan, I., Dalton, J.P. and
Carmona, C. (1999) Vaccination with cathepsin L proteases and
with leucineaminopeptidase induces high levels of protection
against fascioliosis in sheep. Infect. Immunol., 67(4):
1954-1961.
PMid:10085042 PMCid:PMC96552 |
|
|
43. James, P.H., John, R.G. and Rick, M.M. (2009) Helminth
immunoregulation: The role of parasite secreted proteins in
modulating host immunity. Mol. Biochem. Parasitol., 167(1):
1-11.
http://dx.doi.org/10.1016/j.molbiopara.2009.04.008
PMid:19406170 PMCid:PMC2706953 |
|
|
44. Vercruysse, J., Knox, D.P., Schetters, Theo, P.M. and
Willadsen, P. (2004) Veterinary parasitic vaccines: pitfalls
and future directions. Trends Parasitol., 20(10): 487-492.
http://dx.doi.org/10.1016/j.pt.2004.07.009 |
|
|
|
45. Prasad, A. and Sankar, M. (2013) Immuno-prophylaxis
against GI nematodes in small ruminants. Molecular Biological
Approaches for Diagnosis and Control of Parasitic Diseases.
Indian Veterinary Research Institute, Izatnagar, U.P., India.
p182. |
|
|
46. Jarrett, W.F.H., Jennings, F.W., McIntyre, W.I.M.,
Mulligan, W. and Urquhart, G.M. (1960) Immunological studies
on Dictyocaulus viviparous infection. Immunity produced by the
administration of irradiated larvae. Immunology., 3: 145-151.
PMid:14406846 PMCid:PMC1423971 |
|
|
47. Dhar, D.N. and Sharma, R.L. (1981) Immunization with
irradiated larvae against Dictyocaulus filarial in young
lambs. Vet. Parasitol., 9(2): 125-131.
http://dx.doi.org/10.1016/0304-4017(81)90031-5 |
|
|
48. Miller, T.A. (1978) Industrial development and field use
of the canine hookworm vaccine. Adv. Parasitol., 16: 333-342.
http://dx.doi.org/10.1016/S0065-308X(08)60577-1 |
|
|
49. Knox, D.P. (2000) Development of vaccines against
gastrointestinal nematodes. Parasitology, 120 Suppl: S43-S61.
http://dx.doi.org/10.1017/s0031182099005764 |
|
|
|
50. Kumar, B., Nagar, G., Shakya, M. and Ghosh, S. (2013)
Cross protective vaccine development against ticks. Molecular
Biological Approaches for Diagnosis and Control of Parasitic
Diseases. Indian Veterinary Research Institute, Izatnagar,
U.P., India. p182. |
|
|
51. Willadsen, P., Bird, P., Cobon, G.S. and Hungerford, J.
(1995) Commercialization of a recombinant vaccine against
Boophilus microplus. Parasitology., 110: S43-S50.
http://dx.doi.org/10.1017/S0031182000001487
PMid:7784128 |
|
|
52. Knox, D.P. and Smith, W.D. (2001) Vaccination against
gastrointestinal nematode parasites of ruminants using gut
expressed antigens. Vet. Parasitol., 100(1-2): 21-32.
http://dx.doi.org/10.1016/S0304-4017(01)00480-0 |
|
|
53. Nuttall, P.A., Trimnell, A.R., Kazimirova, M. and Labuda,
M. (2006) Exposed and concealed antigens as vaccine targets
for controlling ticks and tick-borne diseases. Parasite
Immunol., 28(4): 155-163.
http://dx.doi.org/10.1111/j.1365-3024.2006.00806.x
PMid:16542317 |
|
|
54. Garcia, J.C., Montero, C. and Redondo (2000) Control of
ticks resistant to immuinization with Bm86 in cattle
vaccinated with the recombinant antigen Bm95 isolated from the
cattle tick Boophilus microplus. Vaccine, 18(21): 2275-2287.
http://dx.doi.org/10.1016/S0264-410X(99)00548-4 |
|
|
55. Kumar, C.S., Deepesh, G., Mahavir, Y. and Archana, T.
(2012) Edible vaccine: A new platform for the development of
malaria vaccine. (Review).Crit Rev. Eukaryot. Gene Expr.,
22(3): 243-248.
http://dx.doi.org/10.1615/CritRevEukarGeneExpr.v22.i3.70 |
|
|
56. Jacob, S.S., Cherian, S., Sumithra, T.G., Raina, O.K. and
Sankar, M. (2013) Edible vaccines against veterinary parasitic
diseases current status and future prospects. Vaccine, 31(15):
1879-1885.
http://dx.doi.org/10.1016/j.vaccine.2013.02.022
PMid:23485715 |
|
