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Research (Published online: 28-10-2015)

16. Application of hyaluronic acid in the healing of non-experimental open wounds: A pilot study on 12 wounds in 10 client-owned dogs - Roberta Ferrari, Patrizia Boracchi, Stefano Romussi, Giuliano Ravasio and Damiano Stefanello

Veterinary World, 8(10): 1247-1259



   doi: 10.14202/vetworld.2015.1247-1259


Roberta Ferrari: Department of Veterinary Science and Public Health, University of Milan, Milan, Italy;

Patrizia Boracchi: Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy;

Stefano Romussi: Department of Veterinary Science and Public Health, University of Milan, Milan, Italy;

Giuliano Ravasio: Department of Veterinary Science and Public Health, University of Milan, Milan, Italy;

Damiano Stefanello: Department of Veterinary Science and Public Health, University of Milan, Milan, Italy;


Received: 01-07-2015, Revised: 14-09-2015, Accepted: 23-09-2015, Published online: 28-10-2015


Corresponding author: Roberta Ferrari, e-mail:

Citation: Ferrari R, Boracchi P, Romussi S, Ravasio G, Stefanello D (2015) Application of hyaluronic acid in the healing of non-experimental o pen wounds: A pilot study on 12 wounds in 10 client-owned dogs, Veterinary World 8(10): 1247-1259.

Aim: Veterinarians have frequently to deal with wounds to the skin, subcutis, and underlying muscle. The aim was to explore the application of hyaluronic acid (HA)-containing dressing on open skin wounds in dogs. The progress of healing was assessed by wound area reduction and two scoring scales applied in human medicine.

Materials and Methods: Ten client-owned dogs with 12 cutaneous open wounds healed by the second intention were included. All wounds were treated using available in commerce HA-containing wound dressing from admission to complete re-epithelialization. At every clinical examination, wound area and scale scoring assessments were performed.

Results: After debridement, an increased wound size was obtained while an improvement was determined by both grading systems. The median numbers of return to the clinic for bandage change were 5 times. The median time to complete wound healing was 34.5 days. The mean wound area at day 7, 14, 21, and 28 were, respectively, 90.4%, 47.7%, 22.4%, and 14.8% of the original size (for linear measurement) and 95.5%, 54.4%, 23.10%, and 14.8% of the original size (for software measurement). Regarding wound healing assessment tools, the agreement between two operators was considered high for both scales.

Conclusions: HA-containing dressing may be a possible wound treatment for cutaneous open wounds in dogs. The assessment of wound quality using scale scoring system could be useful especially in the 1st week and to direct clinical decision-making process.

Keywords: advance wound dressing, canine, wound assessment.

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