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Review (Published online: 29-01-2016)

16. Potential of acute phase proteins as predictor of postpartum uterine infections during transition period and its regulatory mechanism in dairy cattle - A. Manimaran, A. Kumaresan, S. Jeyakumar, T. K. Mohanty, V. Sejian, Narender Kumar, L. Sreela, M. Arul Prakash, P. Mooventhan, A. Anantharaj and D. N. Das

Veterinary World, 9(1): 91-100



   doi: 10.14202/vetworld.2016.91-100



A. Manimaran: Southern Regional Station, ICAR - National Dairy Research Institute, Adugodi, Bengaluru - 560 030, Karnataka, India;

A. Kumaresan: Theriogenology Laboratory, ICAR - National Dairy Research Institute, Karnal-132 001, Haryana, Uttar Pradesh, India;

S. Jeyakumar: Southern Regional Station, ICAR - National Dairy Research Institute, Adugodi, Bengaluru - 560 030, Karnataka, India;

T. K. Mohanty: Theriogenology Laboratory, ICAR - National Dairy Research Institute, Karnal-132 001, Haryana, Uttar Pradesh, India;

V. Sejian: Southern Regional Station, ICAR - National Dairy Research Institute, Adugodi, Bengaluru - 560 030, Karnataka, India;

Narender Kumar: Southern Regional Station, ICAR - National Dairy Research Institute, Adugodi, Bengaluru - 560 030, Karnataka, India;

L. Sreela: ICAR - National Dairy Research Institute, Karnal - 132 001, Haryana, India;

M. Arul Prakash: ICAR - National Dairy Research Institute, Karnal - 132 001, Haryana, India;

P. Mooventhan: ICAR - National Dairy Research Institute, Karnal - 132 001, Haryana, India;

A. Anantharaj: Southern Regional Station, ICAR - National Dairy Research Institute, Adugodi, Bengaluru - 560 030, Karnataka, India;

D. N. Das: Southern Regional Station, ICAR - National Dairy Research Institute, Adugodi, Bengaluru - 560 030, Karnataka, India;


Received: 10-08-2015, Revised: 04-12-2015, Accepted: 12-12-2015, Published online: 29-01-2016


Corresponding author: S. Jeyakumar, e-mail:

Citation: Manimaran A, Kumaresan A, Jeyakumar S, Mohanty TK, Sejian V, Kumar N, Sreela L, Prakash MA, Mooventhan P, Anantharaj A, Das DN (2016) Potential of acute phase proteins as predictor of postpartum uterine infections during transition period and its regulatory mechanism in dairy cattle, Veterinary World 9(1): 91-100.

Among the various systemic reactions against infection or injury, the acute phase response is the cascade of reaction and mostly coordinated by cytokines-mediated acute phase proteins (APPs) production. Since APPs are sensitive innate immune molecules, they are useful for early detection of inflammation in bovines and believed to be better discriminators than routine hematological parameters. Therefore, the possibility of using APPs as a diagnostic and prognostic marker of inflammation in major bovine health disorders including postpartum uterine infection has been explored by many workers. In this review, we discussed specifically importance of postpartum uterine infection, the role of energy balance in uterine infections and potential of APPs as a predictor of postpartum uterine infections during the transition period and its regulatory mechanism in dairy cattle.

Keywords: cute phase proteins, bovine uterine infections, pro-inflammatory cytokines, negative energy balance, transition period.

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