Open Access
R eview
(Published
online:
29-01-2016)
16.
Potential of acute phase proteins as
predictor of postpartum uterine infections during transition
period and its regulatory mechanism in dairy cattle -
A. Manimaran, A. Kumaresan, S. Jeyakumar, T. K. Mohanty, V.
Sejian, Narender Kumar, L. Sreela, M. Arul Prakash,
P. Mooventhan, A. Anantharaj and D. N. Das
Veterinary World, 9(1): 91-100
doi:
10.14202/vetworld.2016.91-100
A. Manimaran:
Southern Regional Station, ICAR - National Dairy Research
Institute, Adugodi, Bengaluru - 560 030, Karnataka, India;
maranpharma@gmail.com
A. Kumaresan:
Theriogenology Laboratory, ICAR - National Dairy Research
Institute, Karnal-132 001, Haryana, Uttar Pradesh, India;
ogkumaresan@gmail.com
S. Jeyakumar:
Southern Regional Station, ICAR - National Dairy Research
Institute, Adugodi, Bengaluru - 560 030, Karnataka, India;
jeyakumarsakthivel@gmail.com
T. K. Mohanty:
Theriogenology Laboratory, ICAR - National Dairy Research
Institute, Karnal-132 001, Haryana, Uttar Pradesh, India;
mohanty.tushar@gmail.com
V. Sejian:
Southern Regional Station, ICAR - National Dairy Research
Institute, Adugodi, Bengaluru - 560 030, Karnataka, India;
drsejian@gmail.com
Narender Kumar:
Southern Regional Station, ICAR - National Dairy Research
Institute, Adugodi, Bengaluru - 560 030, Karnataka, India;
nklangyan@gmail.com
L. Sreela:
ICAR - National Dairy Research Institute, Karnal - 132 001,
Haryana, India; sreela312@gmail.com
M. Arul Prakash:
ICAR - National Dairy Research Institute, Karnal - 132 001,
Haryana, India; drarullpm@gmail.com
P. Mooventhan:
ICAR - National Dairy Research Institute, Karnal - 132 001,
Haryana, India; agriventhan@yahoo.co.in
A. Anantharaj:
Southern Regional Station, ICAR - National Dairy Research
Institute, Adugodi, Bengaluru - 560 030, Karnataka, India;
cellsig2ananth@gmail.com
D. N. Das:
Southern Regional Station, ICAR - National Dairy Research
Institute, Adugodi, Bengaluru - 560 030, Karnataka, India;
dndasndri@gmail.com
Received: 10-08-2015, Revised: 04-12-2015, Accepted: 12-12-2015,
Published online: 29-01-2016
Corresponding author:
S. Jeyakumar, e-mail: jeyakumarsakthivel@gmail.com
Citation:
Manimaran A, Kumaresan A, Jeyakumar S, Mohanty TK, Sejian V,
Kumar N, Sreela L, Prakash MA, Mooventhan P, Anantharaj A, Das
DN (2016) Potential of acute phase proteins as predictor of
postpartum uterine infections during transition period and its
regulatory mechanism in dairy cattle,
Veterinary World 9(1):
91-100.
Abstract
Among the various systemic reactions against infection or
injury, the acute phase response is the cascade of reaction and
mostly coordinated by cytokines-mediated acute phase proteins (APPs)
production. Since APPs are sensitive innate immune molecules,
they are useful for early detection of inflammation in bovines
and believed to be better discriminators than routine
hematological parameters. Therefore, the possibility of using
APPs as a diagnostic and prognostic marker of inflammation in
major bovine health disorders including postpartum uterine
infection has been explored by many workers. In this review, we
discussed specifically importance of postpartum uterine
infection, the role of energy balance in uterine infections and
potential of APPs as a predictor of postpartum uterine
infections during the transition period and its regulatory
mechanism in dairy cattle.
Keywords:
cute phase proteins, bovine uterine infections, pro-inflammatory
cytokines, negative energy balance, transition period.
References
1. Lewis, G.S. (1997) Symposium: Health problems of the
postpartum cow. J. Dairy Sci., 80: 984-994.
http://dx.doi.org/10.3168/jds.S0022-0302(97)76024-7 |
|
|
2. Sheldon, I.M. and Dobson, H. (2004) Postpartum uterine
health in cattle. Anim. Reprod. Sci., 82-83: 295-306.
http://dx.doi.org/10.1016/j.anireprosci.2004.04.006
PMid:15271461 |
|
|
3. LeBlanc, S.J., Osawa, T. and Dubuc, J. (2011)
Reproductive tract defense and disease in postpartum dairy
cows. Theriogenology, 76(9): 1610-1618.
http://dx.doi.org/10.1016/j.theriogenology.2011.07.017
PMid:21890187 |
|
|
4. LeBlanc, S.J. (2008) Production diseases of the
transition cow. Postpartum uterine diseases and dairy herd
reproductive performance: A review. Vet. J., 176(1):
102-114.
http://dx.doi.org/10.1016/j.tvjl.2007.12.019
PMid:18328749 |
|
|
|
5. Rantibioticn, S.R.P. and Bawa, S.J.S. (1977) Incidence of
pre and postpartum reproductive disorders in buffaloes.
Haryana Vet., 16: 99-101. |
|
|
|
6. Pal, S. (2003) Investigation on health disorder in dairy
cattle and buffaloes during pre and postpartum period.
M.V.Sc. Thesis Submitted to NDRI, Karnal. |
|
|
7. Williams, E.J., Fischer, D.P., Pfeiffer, D.U., England,
G.C.W., Noakes, D.E., Dobson, H. and Sheldon, I.M. (2005)
Clinical evaluation of postpartum vaginal mucus reflects
uterine bacterial infection and the immune response in
cattle. Theriogenology, 63: 102-117.
http://dx.doi.org/10.1016/j.theriogenology.2004.03.017
PMid:15589277 |
|
|
8. Dubuc, J., Duffield, T.F., Leslie, K.E., Walton, J.S. and
LeBlanc, S.J. (2011a) Impact of postpartum uterine diseases
on milk production and culling in dairy cows. J. Dairy Sci.,
94(3): 1339-1346.
http://dx.doi.org/10.3168/jds.2010-3758
PMid:21338799 |
|
|
9. Plaizier, J.C., King, G.J., Dekkers, J.C. and Lissemore,
K. (1997) Estimation of economic values of indices for
reproductive performance in dairy herds using computer
simulation. J. Dairy Sci., 80(11): 2775-2783.
http://dx.doi.org/10.3168/jds.S0022-0302(97)76240-4 |
|
|
10. Mateus, L., Costa, L.L.D., Bernardo, F. and Silva, J.R.
(2002) Influence of puerperal uterine infection on uterine
involution and postpartum ovarian activity in dairy cows.
Reprod. Dom. Anim., 37(1): 31-35.
http://dx.doi.org/10.1046/j.1439-0531.2002.00317.x |
|
|
11. Kim, I.H., Na, K.J. and Yang, M.P. (2005) Immune
responses during the peripartum period in dairy cows with
postpartum endometritis. J. Reprod. Dev., 51: 757-764.
http://dx.doi.org/10.1262/jrd.17036
PMid:16210780 |
|
|
12. Galvão, K.N., Santos, N.R., Galvao, J.S. and Gilbert,
R.O. (2011) Association between endometritis and endometrial
cytokine expression in postpartum Holstein cows.
Theriogenology, 76: 290-299.
http://dx.doi.org/10.1016/j.theriogenology.2011.02.006
PMid:21496904 |
|
|
13. Hammon, D.S., Evjen, I.M., Dhiman, T.R., Goff, J.P. and
Walters, J.L. (2006) Neutrophil function and energy status
in Holstein cows with uterine health disorders. Vet.
Immunol. Immunopathol., 113: 21-29.
http://dx.doi.org/10.1016/j.vetimm.2006.03.022
PMid:16740320 |
|
|
14. Humblet, M.F., Guyot, H., Boudry, B., Mbayahi, F.,
Hanzen, C., Rollin, F. and Godeau, J.M. (2006) Relationship
between haptoglobin, serum amyloid A, and clinical status in
a survey of dairy herds during a 6-month period. Vet. Clin.
Pathol., 35: 188-193.
http://dx.doi.org/10.1111/j.1939-165X.2006.tb00112.x
PMid:16783711 |
|
|
15. Kovac, G., Popelkova, M., Tkacikova, L., Burdova, O. and
Ihnat, O. (2007) Interrelationship between somatic cell
count and acute phase proteins in serum and milk of dairy
cows. Acta Vet. Brno., 76: 51-57.
http://dx.doi.org/10.2754/avb200776010051 |
|
|
16. Chan, J.P.W., Chang, C.C., Chin, C., Hsu, W.L., Liu,
W.B. and Chen, T.H. (2010) Association of increased serum
acute-phase protein concentrations with reproductive
performance in dairy cows with postpartum metritis. Vet.
Clin. Pathol., 39(1): 72-78.
http://dx.doi.org/10.1111/j.1939-165X.2009.00182.x
PMid:19747184 |
|
|
17. Huzzey, J.M., Duffield, T.F., LeBlanc, S.J., Veira,
D.M., Weary, D.M. and von Keyserlingk, M.A.G. (2009) Short
communication: Haptoglobin as an early indicator of
metritis. J. Dairy Sci., 92(2): 621-625.
http://dx.doi.org/10.3168/jds.2008-1526
PMid:19164673 |
|
|
18. Huzzey, J.M., Nydam, D.V., Grant, R.J. and Overton, T.R.
(2011) Associations of prepartum plasma cortisol,
haptoglobin, fecal cortisol metabolites, and nonesterified
fatty acids with postpartum health status in Holstein dairy
cows. J. Dairy Sci., 94(12): 5878-5889.
http://dx.doi.org/10.3168/jds.2010-3391
PMid:22118079 |
|
|
19. Dubuc, J., Duffield, T.F., Leslie, K.E., Walton, J.S.
and LeBlanc, S.J. (2010) Risk factors for postpartum uterine
diseases in dairy cows. J. Dairy Sci., 93(12): 5764-5771.
http://dx.doi.org/10.3168/jds.2010-3429
PMid:21094748 |
|
|
20. Eckersall, P.D. and Bell, R. (2010) Acute phase
proteins: Biomarkers of infection and inflammation in
veterinary medicine. Vet. J., 185(1): 23-27.
http://dx.doi.org/10.1016/j.tvjl.2010.04.009
PMid:20621712 |
|
|
21. Ceciliani, F., Ceron, J.J., Eckersall, P.D. and
Sauerwein, H. (2012) Acute phase proteins in ruminants. J.
Proteomics, 75(14): 4207-4231.
http://dx.doi.org/10.1016/j.jprot.2012.04.004
PMid:22521269 |
|
|
|
22. Gilbert, R.O., Santos, N.R., Galvao, K.N., Brittin, S.B.
and Roman, H.B. (2007) The relationship between postpartum
uterine bacterial infection (BI) and subclinical
endometritis (SE). J. Dairy Sci., 90(1): 469. |
|
|
23. Beutler, B., Hoebe, K., Du, X. and Ulevitch, R.J. (2003)
How we detect microbes and respond to them: Toll-like
receptors and their transducers. J. Leuk. Biol., 74:
479-485.
http://dx.doi.org/10.1189/jlb.0203082 |
|
|
24. Fischer, C., Drillich, M., Odau, S., Heuwieser, W.,
Einspanier, R. and Gabler, C. (2010) Selected
pro-inflammatory factor transcripts in bovine endometrial
epithelial cells are regulated during the oestrous cycle and
elevated in case of subclinical or clinical endometritis.
Reprod. Fertil. Dev., 22: 818-829.
http://dx.doi.org/10.1071/RD09120
PMid:20450834 |
|
|
25. Zerbe, H., Schuberth, H.J., Engelke, F., Frank, J., Klug,
E. and Leibold, W. (2003) Development and comparison of in
vivo and in vitro models for endometritis in cows and mares.
Theriogenology, 60: 209-223.
http://dx.doi.org/10.1016/S0093-691X(02)01376-6 |
|
|
26. Zerbe, H., Obadnik, C., Leibold, W. and Schuberth, H.J.
(2001) Influence of Escherichia coli and
Arcanobacteriumpyogenes isolated from bovine puerperal uteri
on phenotypic and functional properties of neutrophils. Vet.
Microbiol., 79: 351-365.
http://dx.doi.org/10.1016/S0378-1135(00)00368-0 |
|
|
27. Herath, S., Lilly, S.T., Santos, N.R., Gilbert, R.O.,
Goetze, L., Bryant, C.E., White, J.O., Cronin, J. and
Sheldon, I.M. (2009) Expression of genes associated with
immunity in the endometrium of cattle with disparate
postpartum uterine disease and fertility. Reprod. Biol.
Endocrinol., 7: 55.
http://dx.doi.org/10.1186/1477-7827-7-55
PMid:19476661 PMCid:PMC2702306 |
|
|
28. Chapwanya, A., Meade, K.G., Doherty, M.L., Callanan,
J.J., Mee, J.F. and O'Farrelly, C. (2009) Histopathological
and molecular evaluation of Holstein-Friesian cows
postpartum: Toward an improved understanding of uterine
innate immunity. Theriogenology, 71: 1396-1407.
http://dx.doi.org/10.1016/j.theriogenology.2009.01.006
PMid:19233457 |
|
|
29. Ishikawa, Y., Nakada, K., Hagiwara, K., Kirisawa, R.,
Iwai, H., Moriyoshi, M. and Sawamukai, Y. (2004) Changes in
interleukin-6 concentration in peripheral blood of pre-and
post-partum dairy cattle and its relationship to postpartum
reproductive diseases. J. Vet. Med. Sci., 66(11): 1403-1408.
http://dx.doi.org/10.1292/jvms.66.1403 |
|
|
30. Islama, R., Kumar, H., Nandi, S. and Rai, R.B. (2013)
Determination of anti-inflammatory cytokine in periparturient
cows for prediction of postpartum reproductive diseases.
Theriogenology, 79: 974-979.
http://dx.doi.org/10.1016/j.theriogenology.2013.01.018
PMid:23434356 |
|
|
31. Kasimanickam, R.K., Kasimanickam, V.R., Olsen, J.R.,
Jeffress, E.J., Moore, D.A. and Kastelic, J.P. (2013)
Associations among serum pro-and anti-inflammatory
cytokines, metabolic mediators, body condition, and uterine
disease in postpartum dairy cows. Reprod. Biol. Endocrinol.,
11: 103.
http://dx.doi.org/10.1186/1477-7827-11-103
PMid:24209779 PMCid:PMC3830449 |
|
|
32. Sordillo, L.M., Pighetti, G.M. and Davis, M.R. (1995)
Enhanced production of bovine tumor necrosis factor-alpha
during the periparturientperiod. Vet. Immunol.
Immunopathol., 49: 263-270.
http://dx.doi.org/10.1016/0165-2427(95)05465-0 |
|
|
33. Trevisi, E., Amadori, M., Bakudila, A.M. and Bertoni, G.
(2009) Metabolic changes in dairy cows induced by oral,
low-dose interferon-alpha treatment. J. Anim. Sci., 87:
3020-3029.
http://dx.doi.org/10.2527/jas.2008-1178
PMid:19502505 |
|
|
34. Bradford, B.J., Mamedova, L.K., Minton, J.E., Drouillard,
J.S. and Johnson. B.J. (2009) Daily injection of tumor
necrosis factor-α increases hepatic triglycerides and alters
transcript abundance of metabolic genes in lactating dairy
cattle. J. Nutr., 139: 1451-1456.
http://dx.doi.org/10.3945/jn.109.108233
PMid:19549751 |
|
|
35. Loor, J.J. and Everts, R.E. (2007) Nutrition-induced
ketosis alters metabolic and signaling gene networks in
liver of periparturient dairy cows. Physiol. Genomics.,
32(1): 105-116.
http://dx.doi.org/10.1152/physiolgenomics.00188.2007
PMid:17925483 |
|
|
36. Beam, S.W. and Butler, W.R. (1998) Energy balance,
metabolic hormones, and early postpartum follicular
development in dairy cows fed prilled lipid. J. Dairy Sci.,
81: 121-131.
http://dx.doi.org/10.3168/jds.S0022-0302(98)75559-6 |
|
|
37. Wathes, D.C, Cheng, Z., Chowdhury, W., Fenwick, M.A,
Fitzpatrick, R., Morris, D.G, Patton, J. and Murphy, J.J.
(2009) Negative energy balance alters global gene expression
and immune responses in the uterus of postpartum dairy cows.
Physiol. Genomics., 39: 1-13.
http://dx.doi.org/10.1152/physiolgenomics.00064.2009
PMid:19567787 PMCid:PMC2747344 |
|
|
38. Galvao, K.N., Flaminio, M.J.B., Brittin, S.B., Sper, R.,
Fraga, M., Caixeta, L., Ricci, A., Guard, C.L., Butler, W.R.
and Gilbert, R.O. (2010) Association between uterine disease
and indicators of neutrophil and systemic energy status in
lactating Holstein cows. J. Dairy Sci., 93: 2926-2937.
http://dx.doi.org/10.3168/jds.2009-2551
PMid:20630210 |
|
|
39. Giuliodori, M.J., Magnasco, R.P., Becu-Villalobos, D.,
Lacau-Mengido, I.M., Risco, C.A. and De la Sota R.L. (2013)
Clinical endometritis in an Argentinean herd of dairy cows:
Risk factors and reproductive efficiency. J. Dairy Sci.,
96(1): 210-218.
http://dx.doi.org/10.3168/jds.2012-5682
PMid:23182361 |
|
|
40. Bell, M.J. and Roberts, D.J. (2007) The impact of
uterine infection on a dairy cow's performance.
Theriogenology, 68: 1074-1079.
http://dx.doi.org/10.1016/j.theriogenology.2007.08.010
PMid:17869332 |
|
|
|
41. Rossi, F., Righi, F., Romanelli, S. and Quarantelli, A.
(2008) Reproductive efficiency of dairy cows under negative
energy balance conditions. Ann. Fac. Med. Vet. Parma., 28:
173-180. |
|
|
42. Silva, E., Gaivao, M., Leitao, S., Antibioticro, A. and
Costa, L.L. (2008) Blood COX-2 and PGES gene transcription
during the peripartum period of dairy cows with normal
puerperium or with uterine infection. Domest. Anim.
Endocrinol., 35: 314-323.
http://dx.doi.org/10.1016/j.domaniend.2008.07.001
PMid:18692980 |
|
|
43. Cairoli, F., Battocchio, M., Veronesi, M.C., Brambilla,
D., Conserva, F., Eberini, I., Wait, R. and Gianazza, E.
(2006) Serum protein pattern during cow pregnancy:
Acute-phase proteins increase in the Peripartum period.
Electrophoresis, 27: 1617-1625.
http://dx.doi.org/10.1002/elps.200500742
PMid:16548048 |
|
|
44. Petersen, H.H., Nielsen, J.P. and Heegaard, P.M.H.
(2004) Application of acute phase protein measurement in
veterinary clinical chemistry. Vet. Res., 35: 163-187.
http://dx.doi.org/10.1051/vetres:2004002
PMid:15099494 |
|
|
45. Eckersall, P.D. and Conner, J.G. (1988) Bovine and
canine acute phase proteins. Vet. Res., 12(2-3): 169-178.
http://dx.doi.org/10.1007/bf00362798 |
|
|
46. Alsemgeest, S.P.M., Kalsbeek, H.C., Wensing, T., Koeman,
J.P., Van Ederen, A.M. and Gruys, E. (1994) Concentrations
of SAA (SAA) and haptoglobin (Hp) as parameters of
inflammatory diseases in cattle. Vet. Q., 16: 21-23.
http://dx.doi.org/10.1080/01652176.1994.9694410
PMid:8009814 |
|
|
|
47. Gruys, E., Ederen, A.M., Alsemgeest, S.P.M., Kalsbeek,
H.C. and Wensing, T. (1993) Acute phase protein values in
blood of cattle as indicator of animals with pathological
process. Arch. Lebensmittel Hyg., 44(5): 107-111. |
|
|
48. Horadagoda, A., Eckersall, P.D., Hodgson, J.C., Gibbs,
H.A. and Moon, G.M. (1994) Immediate responses in serum TNF-α
and acute phase protein concentrations to infection with
Pasteurella haemolytica A1 in calves. Res. Vet. Sci., 57:
129-132.
http://dx.doi.org/10.1016/0034-5288(94)90094-9 |
|
|
49. Horadagoda, N.U., Knox, K.M.G., Gibbs, H.A., Reid, S.W.J.,
Horadagoda, A., Edwards, S.E.R. and Eckersall, P.D. (1999)
Acute phase proteins in cattle: Discrimination between acute
and chronic inflammation. Vet. Rec., 144: 437-441.
http://dx.doi.org/10.1136/vr.144.16.437 |
|
|
50. Pyorala, S. (2000) Hirvonen's Thesis on Acute Phase
Response in Dairy Cattle. Finnland: University of Helsinki.
| |
51. Murata, H., Shimada, N. and Yoshioka, M. (2004)
Current research on acute phase proteins in
veterinary diagnosis: An overview. Vet. J., 168:
28-40.
http://dx.doi.org/10.1016/s1090-0233(03)00119-9 |
|
|
52. Eckersall, P.D., Young, F.J., McComb, C.,
Hogarth, C.J., Safi, S., Weber, A., McDonald, T.,
Nolan, A.M. and Fitzpatrick, J.L. (2001) Acute phase
proteins in serum and milk from dairy cows with
clinical mastitis. Vet. Rec., 148(2): 35-41.
http://dx.doi.org/10.1136/vr.148.2.35 |
|
|
53. Suojala, L., Orro, T., Jarvinen, H., Saatsi, J.
and Pyorala, S. (2008) Acute phase response in two
consecutive experimentally induced E. coli
intra-mammary infections in dairy cows. Acta Vet.
Scand., 50: 18.
http://dx.doi.org/10.1186/1751-0147-50-18
PMid:18554387 PMCid:PMC2440372 |
|
|
54. Wenz, J.R., Fox, L.K., Muller, F.J., Rinaldi,
M., Zeng, R. and Bannerman, D.D. (2010) Factors
associated with concentrations of select cytokine
and acute phase proteins in dairy cows with
naturally occurring clinical mastitis. J. Dairy Sci.,
93: 2458-2470.
http://dx.doi.org/10.3168/jds.2009-2819
PMid:20494154 |
|
|
55. Larsen, T., Rontved, C.M., Ingvartsen, K.L.,
Vels, L. and Bjerring, M. (2010) Enzyme activity and
acute phase proteins in milk utilized as indicators
of acute clinical E. coli LPS-induced mastitis.
Animal, 4: 1672-1679.
http://dx.doi.org/10.1017/S1751731110000947
PMid:22445120 |
|
|
|
56. Krakowski, L. and Zdzisińska, B. (2007) Selected
cytokines and acute phase proteins in heifers during
the ovarian cycle course and in different pregnancy
periods. Bull. Vet. Inst. Pulway., 51: 31-36. |
|
|
57. Smith, B.I., Donovan, G.A., Risco, C., Littell,
R., Young, C., Stanker, L.H. and Elliott, J. (1998b)
Comparison of various antibiotic treatments for cows
diagnosed with toxic puerperal metritis. J. Dairy
Sci., 81(6): 1555-1562.
http://dx.doi.org/10.3168/jds.S0022-0302(98)75721-2 |
|
|
58. Hirvonen, J., Huszenicza, G., Kulcsar, M. and
Pyorala, S., (1999) Acute-phase response in dairy
cows with acute postpartum metritis. Theriogenology,
51: 1071-1083.
http://dx.doi.org/10.1016/S0093-691X(99)80012-0 |
|
|
59. Jeremejeva, J., Orro, T., Waldmann, A. and Kask,
K. (2012) Treatment of dairy cows with PGF2α or
NSAID, in combination with antibiotics, in cases of
postpartum uterine inflammation. Acta Vet. Scand.,
54: 45.
http://dx.doi.org/10.1186/1751-0147-54-45
PMid:22883439 PMCid:PMC3502358 |
|
|
|
60. Mordark, R. (2009) Postpartum serum
concentration of haptoglobin in cows with fetal
membranes retention. Cattle Pract., 17: 100-102. |
|
|
61. Williams, E.J., Fischer, D.P., Noakes, D.E.,
England, G.C., Rycroft, A., Dobson, H. and Sheldon,
I.M. (2007) The relationship between uterine
pathogen growth density and ovarian function in the
postpartum dairy cow. Theriogenology, 68: 549-559.
http://dx.doi.org/10.1016/j.theriogenology.2007.04.056
PMid:17574659 PMCid:PMC2702080 |
|
|
62. Baumann, H. and Gauldie, J. (1994) The acute
phase response. Immunol. Today, 15: 74-80.
http://dx.doi.org/10.1016/0167-5699(94)90137-6 |
|
|
63. Regassa, F. and Noakes, D.E. (1999) Acute phase
protein response of ewes and the release of PGFM in
relation to uterine involution and the presence of
intrauterine bacteria. Vet. Rec., 144: 502-506.
http://dx.doi.org/10.1136/vr.144.18.502
PMid:10358889 |
|
|
64. Sheldon, I.M., Noakes, D.E., Rycroft, A.N. and
Dobson, H. (2001) Acute phase protein responses to
uterine bacterial contamination in cattle after
calving. Vet. Rec., 148(6): 172-175.
http://dx.doi.org/10.1136/vr.148.6.172 |
|
|
65. Heidarpour, M., Mohri, M., Fallah Rad, A.H.,
Shahreza, F.D. and Mohammadi, M. (2012) Acute-phase
protein concentration and metabolic status affect
the outcome of treatment in cows with clinical and
subclinical endometritis. Vet. Rec., 171: 1-5.
http://dx.doi.org/10.1136/vr.100947
PMid:22865113 |
|
|
66. Schneider, A., Corrêa, M.N. and Butler, W.R.
(2013) Acute phase proteins in Holstein cows
diagnosed with uterine infection. Res. Vet. Sci.,
95(1): 269-271.
http://dx.doi.org/10.1016/j.rvsc.2013.02.010
PMid:23540606 |
|
|
67. Kovac, G., Tothova, C., Nagy, O., Seidel, H. and
Konvicna, J. (2009) Acute phase proteins and their
relation to energy metabolites in dairy cows during
the pre- and postpartal period. Acta Vet. Brno., 78:
441-447.
http://dx.doi.org/10.2754/avb200978030441 |
|
|
68. Young, C.R., Eckersall, P.D., Saini, P.K. and
Stanker, L. (1995) Validation of immunoassays for
bovine haptoglobin. Vet. Immunol. Immunopathol., 49:
1-13.
http://dx.doi.org/10.1016/0165-2427(95)05454-E |
|
|
69. Alsemgeest, S.P.M., Vant Clooster, G.A.E., Van
Miert A.S.J., Hulskamp-Koch, C.K. and Gruys, E.
(1996) Primary bovine hepatocytes in the study of
cytokine induced acute-phase protein secretion in
vitro. Vet. Immunol. Immunopathol., 53: 179-184.
http://dx.doi.org/10.1016/0165-2427(96)05602-4 |
|
|
|
70. Mordak, R. (2008) Usefulness of haptoglobin for
monitoring the efficiency of therapy of fetal
membrane retention in cows. Med. Wet., 64(4A):
434-443. |
|
|
71. Chan, J.P., Chu, C.C., Fung, H.P., Chuang, S.T.,
Lin, Y.C., Chu, R.M. and Lee, S.L. (2004) Serum
haptoglobin concentration in cattle. J. Vet. Med.
Sci., 66(1): 43-46.
http://dx.doi.org/10.1292/jvms.66.43 |
|
|
|
72. Sabedra, D.A. (2012) Thesis on Serum Haptoglobin
as an Indicator for Calving Difficulties and
Postpartal Diseases in Transition Dairy Cows. An
Undergraduate Thesis Submitted to Oregon State
University. |
|
|
73. Burke, C.R., Meier, S., McDougall, S., Compton,
C., Mitchell, M. and Roche, J.R. (2010)
Relationships between endometritis and metabolic
state during the transition period in pasture-grazed
dairy cows. J. Dairy Sci., 93: 5363-5373.
http://dx.doi.org/10.3168/jds.2010-3356
PMid:20965352 |
|
|
74. Huzzey, J.M., Mann, S., Nydam, D.V., Grant, R.J.
and Overton, T.R. (2015) Associations of peripartum
markers of stress and inflammation with milk yield
and reproductive performance in Holstein dairy cows.
Prev. Vet. Med., 120(3-4): 291-297.
http://dx.doi.org/10.1016/j.prevetmed.2015.04.011
PMid:25957974 |
|
|
75. Krausea, A.R.T., Pfeifer, L.F.M., Montagnera,
P., Weschenfeldera, M.M., Schweglera, E., Limaa, M.E.,
Xavierb, E.G., Braunera, C.C., Schmittc, E., Del
Pinoa, F.A.B., Martinsa, C.F., Corrêaa, M.N. and
Schneidera, A. (2014) Associations between
resumption of postpartum ovarian activity, uterine
health and concentrations of metabolites and acute
phase proteins during the transition period in
Holstein cows. Anim. Reprod. Sci., 145: 8-14.
http://dx.doi.org/10.1016/j.anireprosci.2013.12.016
PMid:24444884 |
|
|
76. Nightingale, C.R., Sellers, M.D. and Ballou,
M.A. (2015) Elevated plasma haptoglobin
concentrations following parturition are associated
with elevated leukocyte responses and decreased
subsequent reproductive efficiency in multiparous
Holstein dairy cows. Vet. Immunol. Immunopathol.,
164: 16-23.
http://dx.doi.org/10.1016/j.vetimm.2014.12.016
PMid:25613776 |
|
|
77. Gabler, C., Fischer, C., Drillich, M.,
Einspanier, R. and Heuwieser, W. (2010)
Time-dependent mRNA expression of selected
pro-inflammatory factors in the endometrium of
primiparous cows postpartum. Reprod. Biol.
Endocrinol., 8: 152.
http://dx.doi.org/10.1186/1477-7827-8-152
PMid:21176181 PMCid:PMC3016299 |
|
|
78. Lecchi, C., Avallone, G., Giurovich, M.M.,
Roccabianca, P. and Ceciliani, F. (2009) Extra
hepatic expression of the acute phase protein alpha
1-acid glycoprotein in normal bovine tissues. Vet.
J., 180(2): 256-258.
http://dx.doi.org/10.1016/j.tvjl.2007.12.027
PMid:18294879 |
|
|
79. Rahman, M.M. and Lecchi, C. (2010)
Lipopolysaccharide-binding protein: Local expression
in bovine extrahepatic tissues. Vet. Immunol.
Immunopathol., 137: 28-35.
http://dx.doi.org/10.1016/j.vetimm.2010.04.006
PMid:20452064 |
|
|
80. Ghasemi, F., Gonzalez-Cano, P., Griebel, P.J.
and Palmer, C. (2012) Proinflammatory cytokine gene
expression in endometrial cytobrush samples
harvested from cows with and without subclinical
endometritis. Theriogenology, 78(7): 1538-1547.
http://dx.doi.org/10.1016/j.theriogenology.2012.06.022
PMid:22925636 |
|
|
81. Galvao, K.N., Felippe, M.J., Brittin, S.B., Sper,
R., Fraga, M., Galvão, J.S., Caixeta, L., Guard, C.L.,
Ricci, A. and Gilbert, R.O. (2012) Evaluation of
cytokine expression by blood monocytes of lactating
Holstein cows with or without postpartum uterine
disease. Theriogenology, 77(2): 356-372.
http://dx.doi.org/10.1016/j.theriogenology.2011.08.008
PMid:21924475 |
|
|
82. Loyi, T., Kumar, H., Nandi, S., Mathapati, B.S.,
Patra, M.K. and Pattnaik, B. (2013) Differential
expression of pro-inflammatory cytokines in
endometrial tissue of buffaloes with clinical and
sub-clinical endometritis. Res. Vet. Sci., 94:
336-340.
http://dx.doi.org/10.1016/j.rvsc.2012.09.008
PMid:23040421 |
|
|
83. Chapwanya, A., Meade, K.G., Doherty, M.L.,
Callanan, J.J. and O'Farrellya, C. (2013)
Endometrial epithelial cells are potent producers of
tracheal antimicrobial peptide and serum amyloid A3
gene expression in response to E. coli stimulation.
Vet. Immunol. Immunopathol., 151(1-2): 157-162.
http://dx.doi.org/10.1016/j.vetimm.2012.09.042
PMid:23200820 |
|
|
84. Heinrich, P.C., Behrmann, I., Muller-Newen, G.,
Schaper, F. and Graeve, L. (1998) Interleukin-6-type
cytokine signalling through the gp130/Jak/STAT
pathway. Biochem. J., 334: 297-314.
http://dx.doi.org/10.1042/bj3340297
PMid:9716487 PMCid:PMC1219691 |
|
|
85. Agrawal, A., Cha-Molstad, H., Samols, D. and
Kushner, I. (2003) Over expressed nuclear
factor-kappa B can participate in endogenous
C-reactive protein induction, and enhances the
effects of C/EBP beta and signal transducer and
activator of transcription-3. Immunology, 108:
539-547.
http://dx.doi.org/10.1046/j.1365-2567.2003.01608.x
PMid:12667216 PMCid:PMC1782914 |
|
|
86. Jensen, L.E. and Whitehead, A.S. (1998)
Regulation of serum amyloid A protein expression
during the acute-phase response. Biochem. J., 334:
489-503.
http://dx.doi.org/10.1042/bj3340489
PMid:9729453 PMCid:PMC1219714 |
|
|
87. Betts, J.C., Cheshire, J.K., Akira, S.,
Kishimoto, T. and Woo, P. (1993) The role of
NF-kappa B and NF-IL6 trans activating factors in
the synergistic activation of human serum amyloid A
gene expression by interleukin-1 and interleukin-6.
J. Biol. Chem., 268: 25624-25631.
PMid:8244997 |
|
|
88. Edbrooke, M.R., Foldi, J., Cheshire, J.K., Li,
F., Faulkes, D.J. and Woo, P. (1991) Constitutive
and NF-kappa B-like proteins in the regulation of
the serum amyloid A gene by interleukin-1. Cytokine,
3: 380-388.
http://dx.doi.org/10.1016/1043-4666(91)90041-B |
|
|
89. Lee, Y.M., Miau, L.H., Chang, C.J. and Lee, S.C.
(1996) Transcriptional induction of the alpha-1 acid
glycoprotein (AGP) gene by synergistic interaction
of two alternative activator forms of AGP/enhancer-binding
protein (C/EBP beta) and NF-kappa B or Nopp140. Mol.
Cell. Biol., 16: 4257-4263.
http://dx.doi.org/10.1128/MCB.16.8.4257
PMid:8754826 PMCid:PMC231424 |
|
|
90. Hagihara, K., Nishikawa, T., Sugantibioticta,
Y., Song, J., Isobe, T., Taga, T. and Yoshizaki, K.
(2005) Essential role of STAT3 in cytokine-driven
NF-kappaB-mediated serum amyloid A gene expression.
Genes Cells, 10: 1051-1063.
http://dx.doi.org/10.1111/j.1365-2443.2005.00900.x
PMid:16236134 |
|
|
91. Quinton, L.J., Jones, M.R., Robson, B.E. and
Mizgerd, J.P. (2009) Mechanisms of the hepatic
acute-phase response during bacterial pneumonia.
Infect. Immu., 77: 2417-2426.
http://dx.doi.org/10.1128/IAI.01300-08
PMid:19289507 PMCid:PMC2687329 |
|
|
92. Bode, J.G., Albrecht, U., Haussinger, D.,
Heinrich, P.C. and Schaper, F. (2012) Hepatic acute
phase proteins-regulation by IL-6-and IL-1-type
cytokines involving STAT3 and its crosstalk with
NF-kB-dependent signaling. Eur. J. Cell Biol., 91:
496-505.
http://dx.doi.org/10.1016/j.ejcb.2011.09.008
PMid:22093287 |
|
|
