Open Access
Review
(Published
online: 11-11-2016)
10.
Laboratory animal models for esophageal
cancer -
Dhanya Venugopalan Nair and A. Gopala Reddy
Veterinary World, 9(11): 1229-1232
doi:
10.14202/vetworld.2016.1229-1232
Dhanya Venugopalan Nair:
Department of Veterinary Pharmacology and Toxicology, College of
Veterinary Science, Rajendranagar, Hyderabad, Telangana, India;
dhanyavet@gmail.com
A. Gopala Reddy:
Department of Veterinary Pharmacology and Toxicology, College of
Veterinary Science, Rajendranagar, Hyderabad, Telangana, India;
gopalareddy123@rediffmail.com
Received: 30-06-2016, Accepted: 01-10-2016, Published online:
11-11-2016
Corresponding author:
Dhanya Venugopalan Nair, e-mail: dhanyavet@gmail.com
Citation:
Nair DV, Reddy AG (2016) Laboratory animal models for esophageal
cancer,
Veterinary World, 9(11):
1229-1232.
Abstract
The incidence of esophageal cancer is rapidly increasing
especially in developing countries. The major risk factors include
unhealthy lifestyle practices such as alcohol consumption,
smoking, and chewing tobacco to name a few. Diagnosis at an
advanced stage and poor prognosis make esophageal cancer one of
the most lethal diseases. These factors have urged further
research in understanding the pathophysiology of the disease.
Animal models not only aid in understanding the molecular
pathogenesis of esophageal cancer but also help in developing
therapeutic interventions for the disease. This review throws
light on the various recent laboratory animal models for
esophageal cancer.
Keywords:
animal model, cancer, esophagus, mice, rat.
References
|
1. Washington, M.C. and Leaver, D. (2016) Principles and
Practice of Radiation Therapy. 4th ed. Elsevier Mosby,
Philadelphia, PA. p46-47. |
|
|
|
2. Kerr, D.J., Haller, D.G., Van de Velde, C.J.H. and Baumann,
M. (2012) Oxford Textbook of Oncology. 3rd ed. Oxford
University Press, Oxford, UK. p61. |
|
|
|
3. Naufal, R., Mohamed, E., Michael, K. and Amjid, R. (2015)
Current management of oesophageal cancer. Br. J. Med. Pract.,
8(1): a804. |
|
|
4. Ferlay, J., Shin, H.R., Bray, F., Forman, D., Mathers, C.
and Parkin, D.M. (2010) Estimates of worldwide burden of
cancer in 2008: GLOBOCAN 2008. Int. J. Cancer, 127: 2893-2917.
https:/doi.org/10.1002/ijc.25516 |
|
|
5. Ohashi, S., Miyamoto, S., Kikuchi, O., Goto, T., Amanuma,
Y. and Muto, M. (2015) Recent advances from basic and clinical
studies of esophageal squamous Cell carcinoma.
Gastroenterology, 149(7): 1700-1715.
https:/doi.org/10.1053/j.gastro.2015.08.054
PMid:26376349 |
|
|
6. Manish, A.S. (2015) Update on metastatic gastric and
esophageal cancers. J. Clin. Oncol., 33: 1760-1769.
https:/doi.org/10.1200/JCO.2014.60.1799
PMid:25918288 |
|
|
7. Dreikhausen, L., Blank, S., Sisic, L., Heger, U., Weichert,
W., Jäger, D., Bruckner, T., Giese, N., Grenacher, L., Falk,
C., Ott, K. and Schmidt, T. (2015) Association of angiogenic
factors with prognosis in esophageal cancer. BMC Cancer,
15(1): 1-11.
https:/doi.org/10.1186/s12885-015-1120-5 |
|
|
8. Dar, N.A., Shah, I.A., Bhat, G.A., Makhdoomi, M.A., Iqbal,
B., Rafiq, R., Nisar, I., Bhat, A.B., Nabi, S., Masood, A.,
Shah, S.A., Lone, M.M., Zargar, S.A., Islami, F. and Boffetta,
P. (2013) Socioeconomic status and esophageal squamous cell
carcinoma risk in Kashmir India. Cancer Sci., 104(9):
1231-1236.
https:/doi.org/10.1111/cas.12210
PMid:23721087 |
|
|
|
9. IARC Working Group. (2012) Personal habits and indoor
combustions. IARC Monographs on the Evaluation of Carcinogenic
Risks to Humans. Vol. 100E. IARC Press, Lyon. |
|
|
10. Philip, R.T., Christian, C.A. and Sanford, M.D. (2013)
Squamous dysplasia – The precursor lesion for esophageal
squamous cell carcinoma. Cancer Epidemiol. Biomarkers Prev.,
22(4): 540-552.
https:/doi.org/10.1158/1055-9965.EPI-12-1347
PMid:23549398 PMCid:PMC3681095 |
|
|
11. Thrift, A.P. and Whiteman, D.C. (2012) The incidence of
esophageal adenocarcinoma continues to rise: Analysis of
period and birth cohort effects on recent trends. Ann. Oncol.,
23(12): 3155-3162.
https:/doi.org/10.1093/annonc/mds181
PMid:22847812 |
|
|
12. Greene, C.L., Worrell, S.G. and De, M.T.R. (2015) Rat
reflux model of esophageal cancer and its implication in human
disease. Ann. Surg., 262(6): 910-924.
https:/doi.org/10.1097/SLA.0000000000001207
PMid:25822684 |
|
|
13. Hibberd, C., Cossigny, D.A.F. and Quan, G.M.Y. (2013)
Animal cancer models of skeletal metastasis. Cancer Growth
Metastasis, 6: 23-34.
PMid:24665205 PMCid:PMC3941154 |
|
|
14. Saxena, M. and Christofori, G. (2013) Rebuilding cancer
metastasis in the mouse. Mol. Oncol., 7(2): 283-296.
https:/doi.org/10.1016/j.molonc.2013.02.009
PMid:23474222 |
|
|
15. Ruggeri, B.A., Camp, F. and Miknyoczki, S. (2013) Animal
models of disease: Pre-clinical animal models of cancer and
their applications and utility in drug discovery. Biochem.
Pharmacol., 87(1): 150-161.
https:/doi.org/10.1016/j.bcp.2013.06.020
PMid:23817077 |
|
|
16. Hashimoto, N. (2012) Expression of COX2 and p53 in rat
esophageal cancer induced by reflux of duodenal contents. ISRN
Gastroenterology, 2012: 914824.
https:/doi.org/10.5402/2012/914824
PMid:22272378 PMCid:PMC3261458 |
|
|
17. Kumagai, H., Mukaisho, K.I., Sugihara, H., Miwa, K.,
Yamamoto, G. and Hattori, T. (2004) Thioproline inhibits
development of esophageal adenocarcinoma induced by
gastroduodenal reflux in rats. Carcinogenesis, 25(5): 723-727.
https:/doi.org/10.1093/carcin/bgh067
PMid:14754873 |
|
|
18. Hori, T., Yamashita, Y., Ohira, M., Matsumura, Y.,
Muguruma, K. and Hirakawa, K. (2001) A novel orthotopic
implantation model of human esophageal carcinoma in nude rats:
CD44H mediates cancer cell invasion in vitro and in vivo. Int.
J. Cancer, 92(4): 489-496.
https:/doi.org/10.1002/ijc.1234
PMid:11304682 |
|
|
19. Wargovich, M.J., Woods, C., Eng, V.W., Stephens, L.C. and
Gray, K. (1988) Chemoprevention of N-nitrosomethylbenzylamine-induced
oesophageal cancer in rats by the naturally occurring
thioether, diallyl sulfide. Cancer Res., 48(23): 6872-6875.
PMid:3180095 |
|
|
20. Nakagawa, H., Wang, T.C., Zukerberg, L., Odze, R., Togawa,
K., May, G.H., Wilson, J. and Rustgi, A.K. (1997) The
targeting of the cyclin D1 oncogene by an Epstein-Barr virus
promoter in transgenic mice causes dysplasia in the tongue,
esophagus and forestomach. Oncogene, 14(10): 1185-1190.
https:/doi.org/10.1038/sj.onc.1200937
PMid:9121767 |
|
|
21. Jenkins, T.D., Nakagawa, H. and Rustgi, A.K. (1997) The
keratinocyte-specific Epstein-Barr virus ED-L2 promoter is
regulated by phorbol 12-myristate 13-acetate through two cis-regulatory
elements containing e-box and Krüppel-like factor motifs. J.
Biol. Chem., 272(39): 24433-24442.
https:/doi.org/10.1074/jbc.272.39.24433 |
|
|
22. Opitz, O.G., Harada, H., Suliman, Y., Rhoades, B.,
Sharpless, N.E., Kent, R., Kopelovich, L., Nakagawa, H. and
Rustgi, A.K. (2002) A mouse model of human oral-esophageal
cancer. J. Clin. Invest., 110(6): 761-769.
https:/doi.org/10.1172/JCI0215324 |
|
|
23. Quante, M., Bhagat, G., Abrams, J., Marache, F., Good, P.,
Lee, M.D. and Wang, T.C. (2012) Bile acid and inflammation
activate gastric cardia stem cells in a mouse model of
Barrett's-like metaplasia. Cancer Cell, 21(1): 36-51.
https:/doi.org/10.1016/j.ccr.2011.12.004
PMid:22264787 PMCid:PMC3266546 |
|
|
24. Crescenzi, M., Persano, L., Esposito, G., Zulato, E.,
Borsi, L., Balza, E., Ruol, A., Ancona, E., Indraccolo, S. and
Amadori, A. (2011) Vandetanib improves anti-tumor effects of
L19mTNFalpha in xenograft models of esophageal cancer. Clin.
Cancer Res., 17(3): 447-458.
https:/doi.org/10.1158/1078-0432.CCR-10-1420
PMid:21106730 |
|
|
25. Tétreault, M.P. (2015) Oesophageal cancer: Insights from
mouse models. Cancer Growth Metastasis, 8(1): 37-46.
https:/doi.org/10.4137/CGM.S21218
PMid:26380556 PMCid:PMC4558891 |
|
|
26. Shuai, S., Dong, C., Yong, C., Jian, H., Min, G., Kai, M.,
Fang, D., Zhi-Hua, L. and Tian-You, W. (2014) New orthotopic
implantation model of human esophageal squamous cell carcinoma
in athymic nude mice. Thorac. Cancer, 5(5): 417-424.
https:/doi.org/10.1111/1759-7714.12112
PMid:26767033 PMCid:PMC4704367 |
|
|
|
27. Joseph, C.Y.I., Josephine, M.Y.K., Valen, Z.Y., Kwok, W.C.,
Alfred, K.L., Simon, L., Daniel, K.H.T. and Maria, L.L. (2015)
A versatile orthotopic nude mouse model for study of
esophageal squamous cell carcinoma. BioMed Res. Int., 2015:
910715. |
|
|
28. Takahiro, K., Satoshi, I., Masahiro, K., Shun, M.,
Tetsuya, K., Haruki, N., Shojiro, M. and Shinae, K. (2016) A
luciferin analogue generating near-infrared bioluminescence
achieves highly sensitive deep-tissue imaging. Nat. Commun.,
7: 11856.
https:/doi.org/10.1038/ncomms11856
PMid:27297211 PMCid:PMC4911627 |
|
|
|
29. Xianhua, W., Jingchuan, Z., Ruheng, Z., Jing, L.V., Li,
Z., Xinying, S., Guanshan, Z., Paul, R.G., Songtao, X.,
Shaohua, L., Jun, H., Yalan, L., Chen, X., Yunshan, T., Liang,
X., Xiaolu, Y., Deming, H., Qunsheng, J., Yingyong, H. and Di,
G. (2012) Trastuzumab anti-tumor efficacy in patient-derived
esophageal squamous cell carcinoma xenograft (PDECX) mouse
models. J. Transl. Med., 10(1): 1. |
|
|
30. Zhang, J., Jiang, D., Li, X., Lv, J., Xie, L., Zheng, L.,
Gavine, P.R., Hu, Q., Shi, Y., Tan, L., Ge, D., Xu, S., Li,
L., Zhu, L., Hou, Y. and Wang, Q. (2014) Establishment and
characterization of esophageal squamous cell carcinoma
patient-derived xenograft mouse models for preclinical drug
discovery. Lab. Invest., 94: 917-926.
https:/doi.org/10.1038/labinvest.2014.77
PMid:24999713 |
|
|
31. Yang, Z., Guan, B., Men, T., Fujimoto, J. and Xu, X.
(2013) Comparable molecular alterations in 4-nitroquinoline
1-oxide-induced oral and esophageal cancer in mice and in
human esophageal cancer, associated with poor prognosis of
patients. In Vivo, 27(4): 473-484.
PMid:23812217 PMCid:PMC3849809 |
|
|
32. Baba, S., Yamada, Y., Hatano, Y., Miyazaki, Y., Mori, H.,
Shibata, T. and Hara, A. (2009) Global DNA hypomethylation
suppresses squamous carcinogenesis in the tongue and
esophagus. Cancer Sci., 100: 1186-1191.
https:/doi.org/10.1111/j.1349-7006.2009.01171.x
PMid:19432896 |
|
|
33. Tseng, S.H., Yang, C.C., Yu, E.H., Chang, C., Lee, Y.S.,
Liu, C.J., Chang, K.W. and Lin, S.C. (2015) K14-EGFP-miR-31
transgenic mice have high susceptibility to chemical-induced
squamous cell tumorigenesis that is associating with Ku80
repression. Int. J. Cancer, 136(6): 1263-1275.
https:/doi.org/10.1002/ijc.29106
PMid:25082302 |
|
|
34. Akira, O., Takafumi, S., Masao, O., Toshimitsu, K. and
Masayuki, Y. (2013) Roles of keap1–Nrf2 system in upper
aerodigestive tract carcinogenesis. Cancer Prev. Res., 6:
149-159.
https:/doi.org/10.1158/1940-6207.CAPR-12-0401-T
PMid:23250896 |
|
|
35. Zhang, Z., Wang, Y., Yao, R., Li, J., Lubet, R.A. and You,
M. (2006) P53 transgenic mice are highly susceptible to
4-nitroquinoline-1-oxide-induced oral cancer. Mol. Cancer
Res., 4(6): 401-410.
https:/doi.org/10.1158/1541-7786.MCR-06-0028
PMid:16778087 |
|
|
36. Liu, J., Li, N., Li, L., Li, D., Liu, K., Zhao, L., Tang,
J. and Li, L. (2013) Local hyperthermia for esophageal cancer
in a rabbit tumor model: Magnetic stent hyperthermia versus
magnetic fluid hyperthermia. Oncol. Lett., 6(6): 1550-1558.
PMid:24260045 PMCid:PMC3833863 |
|
|
37. Jin, H., Jinquan, S., Guanyin, X., Xiang, W., Yin, Z.,
Xiaowei, T., Zhining, F., Yingzhou, S., Hanming, S. and Zhi,
L. (2014) Establishing a rabbit model of malignant
esophagostenosis using the endoscopic implantation technique
for studies on stent innovation. J. Transl. Med., 12: 40.
https:/doi.org/10.1186/1479-5876-12-40
PMid:24507720 PMCid:PMC3922539 |
|
|
38. Huang, J., Zhang, Y., Zhong, H., Fan, Z., Jiang, G., Shen,
Y., Song, H., Tao, Z. and Wang, K. (2014) Comparison of
endoscopic submuscosal implantation vs. Surgical intramuscular
implantation of VX2 fragments for establishing a rabbit
esophageal tumor model for mimicking human esophageal squamous
carcinoma. PLoS ONE, 9(1): e85326.
https:/doi.org/10.1371/journal.pone.0085326
PMid:24475043 PMCid:PMC3901654 |
|
|
39. Yan-Mei, C., Ai-Li, C., Jian-Pu, Z., Hong-Wei, W.,
Yong-Shun, S., Chun-Fang, L., Bei-Bei, Z., Yi, W., Sheng-Liang,
Z. and Da-Zheng, W. (2014) Airway hyper responsiveness induced
by repeated esophageal infusion of HCl in guinea pigs. J.
Respir. Cell Mol. Biol., 51(5): 701-708.
https:/doi.org/10.1165/rcmb.2013-0484OC
PMid:24828018 |
|
|
40. Qinzi, L., Lingfei, K., Shuna, Z., Zhaoshuang, Z.,
Xiaofeng, L., Jinou, W. and Jian, K. (2010) A novel external
esophageal perfusion model for reflux-associated respiratory
symptoms. Pathobiology, 77: 163-168.
https:/doi.org/10.1159/000292650
PMid:20516732 |
|
|
41. Dunham, L.J. and Sheets, R.H. (1974) Sheets effects of
esophageal constriction on benzo[a]pyrene carcinogenesis in
hamster esophagus and forestomach. JNCI J. Natl. Cancer Inst.,
53(3): 875-881.
PMid:4413133 |
|
|
42. Zhao, J.Y., Wang, F., Li, Y., Zhang, X.B., Yang, L., Wang,
W., Xu, H., Liu, D.Z. and Zhang, L.Y. (2015) Five miRNAs
considered as molecular targets for predicting esophageal
cancer. Med. Sci. Monit., 21: 3222-3230.
https:/doi.org/10.12659/MSM.895001
PMid:26498375 PMCid:PMC4627364 |
|
|
43. Boone, J., Van Hillegersberg, R., Offerhaus, G.J., Van
Diest, P.J., Rinkes, I.H.B. and Kate, F.J.T. (2009) Targets
for molecular therapy in esophageal squamous cell carcinoma:
An immunohistochemical analysis. Dis. Esophagus, 22(6):
496-504.
https:/doi.org/10.1111/j.1442-2050.2009.00951.x
PMid:19302210 |
|
