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Research (Published online: 02-11-2016)

2. Clinico-anesthetic changes following administration of propofol alone and in combination of meperidine and pentazocine lactate in dogs - A. K. Anandmay, L. L. Dass, A. K. Sharma, M. K. Gupta, K. K. Singh and B. K.Roy

Veterinary World, 9(11): 1178-1183



   doi: 10.14202/vetworld.2016.1178-1183



A. K. Anandmay: Touring Veterinary Officer, Department of Animal Husbandry, Adardih Block, Saraikella - 832 401, Jharkhand, India;

L. L. Dass: Department of Veterinary Surgery and Radiology, Ranchi Veterinary College, Birsa Agricultural University, Ranchi - 834 006, Jharkhand, India;

A. K. Sharma: Department of Veterinary Surgery and Radiology, Ranchi Veterinary College, Birsa Agricultural University, Ranchi - 834 006, Jharkhand, India; arsham10@

M. K. Gupta: Department of Veterinary Pathology, Ranchi Veterinary College, Birsa Agricultural University, Ranchi - 834 006, Jharkhand, India;

K. K. Singh: Department of Veterinary Pathology, Ranchi Veterinary College, Birsa Agricultural University, Ranchi - 834 006, Jharkhand, India;

B. K.Roy: Department of Veterinary Pharmacology and Toxicology, Ranchi Veterinary College, Birsa Agricultural University, Ranchi - 834 006, Jharkhand, India;


Received: 29-01-2016, Accepted: 17-09-2016, Published online: 02-11-2016


Corresponding author: A. K. Sharma, e-mail: arsham10@

Citation: Anandmay AK, Dass LL, Sharma AK, Gupta MK, Singh KK, Roy BK (2016) Clinico-anesthetic changes following administration of propofol alone and in combination of meperidine and pentazocine lactate in dogs, Veterinary World, 9(11): 1178-1183.

Aim: The aim of this study is to find out the effect of propofol and its combination with meperidine and pentazocine lactate on certain clinico-anesthetic profiles in dogs.

Materials and Methods: 15 apparently healthy mongrel dogs of either sex of about 1 year of age were randomly divided into three groups of five dogs each. The animals of Group I were administered propofol intravenously alone “to effect,” whereas meperidine at 2 mg/kgb.wt. and pentazocine lactate at 2 mg/kg b.wt. were injected intramuscularly 15 min before propofol “to effect” in Groups II and III, respectively. Atropine sulfate at 0.04 mg/kgb.wt. was injected intramuscularly 20 min before each treatment. Rectal temperature, heart rate, respiration rate, and anesthetic indices were recorded before and at 5, 10, 20, 30, and 60 min of induction.

Results: As compared to Group I, the animals of Groups II and III exhibited a significant decrease (p<0.05) in the level of rectal temperature, respiration rate, and heart rate. Duration of recumbency, time of standing, time of recovery as well as the duration of analgesia were longer in pentazocine lactate (Group III) followed by meperidine (Group II) as compared to propofol alone (Group I). Meperidine treated dogs showed defecation and muscle twitching during anesthesia.

Conclusion: Meperidine and pentazocine are suitable opioids used in combination with propofol for achieving surgical anesthesia and helpful in reduction of propofol dose.

Keywords: clinico-anesthetic changes, dog, meperidine, pentazocine, propofol.

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