Evaluation of the therapeutic efficacy of Vitex agnus-castus extract on cisplatin-induced hematotoxicity in female Wistar rats

Vet World Vol.16 November-2023 Article-1

Research Article

Veterinary World, 16(11): 2186-2191

https://doi.org/10.14202/vetworld.2023.2186-2191

Aparna Tripathy¹, Archana Parampalli Raghavendra¹, Babi Dutta², and Sudarshan Surendran³

1. Division of Physiology, Department of Basic Medical Sciences, MAHE, Manipal, Karnataka, India.
2. Division of Biochemistry, Department of Basic Medical Sciences, MAHE, Manipal, Karnataka, India.
3. Department of Clinical Anatomy and Medical Imaging, American University of Antigua College of Medicine, Antigua.

Background and Aim: Cisplatin (CP) is a preferred drug for cancer treatment but it has dose-dependent side effects. Vitex agnus-castus (VAC) berry extract has antioxidant, free-radical scavenging, and anti-inflammatory activities. This study explored the mitigating effects of VAC extract (VACE) on acute hematotoxicity induced by CP in female Wistar rats.

Materials and Methods: Female Wistar rats (n = 30) were randomly divided into five groups (n = 6/group). The normal control (NC) group received no treatment. The CP control group received CP (7 mg/kg.b.w. ip, single dose) and the drug control group (VACE-650) received VACE (650 mg/kg b.w. oral, daily) for 7 days. Both groups received a single dose of CP (7 mg/kg b.w. ip), followed by 350 and 650 mg/kg.b.w. of VACE daily orally (CPVACE-350 and CPVACE-650 groups, respectively) for 7 days.

Results: After a single dose of CP (7 mg/kg b.w.), the red blood cells (RBC), hematocrit (HCT), white blood cells (WBC), and platelets significantly decreased. In the VAC-350 group, the reduction in total WBC count was less than that in the VAC-650 group on the 3rd day. The RBC and HCT values of the VACE groups were better than that of the CP control, but the VACE-350 treatment group showed significant improvement only on the 3rd day.

Conclusion: Our findings showed that VACE can mitigate CP-induced damage to peripheral blood cells at lower doses. Keywords: cisplatin, hematotoxicity, rats, Vitex agnus-castus.

Keywords: cisplatin, hematotoxicity, rats, Vitex agnus-castus.

How to cite this article: Tripathy A, Raghavendra AP, Dutta B, and Surendran S (2023) Evaluation of the therapeutic efficacy of Vitex agnus-castus extract on cisplatin-induced hematotoxicity in female Wistar rats, Veterinary World, 16(11): 2186-2191.

Received: 19-06-2023 Accepted: 04-10-2023 Published online: 01-11-2023

Corresponding author: Sudarshan Surendran E-mail: ssurendran@auamed.net

DOI: 10.14202/vetworld.2023.2186-2191

Copyright: Tripathy, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.