Aim: The current study was done to study the therapeutic effect of
natural prostaglandin in treatment of canine pyometra.
Materials and Methods:
Seven bitches were treated with natural PGF2α i.e. dinoprost tromethamine at
the dose rate of 100 μg/kg body weight subcutaneously once daily for 7 days with
supportive therapies. The physiological, haematological and biochemical
parameters were studied before (0th day) and after treatment (8th day).
Therapeutic efficacy was assessed in terms of return of abnormal parameters to
either normal or near normal value as compared to the untreated control group,
intensity of side effects and post treatment reproductive status.
All physiological, haematological and biochemical parameters in the seven
treated bitches returned to normal range at the end of treatment. The intensity
of side effects was quite severe in the treatment group. Six bitches came to
estrus within 2 months of treatment and out of them four conceived on subsequent
mating. In rest three bitches there was recurrence of pyometra within 4 months
Conclusion: Though conception rate of recovered bitches is
decreased when compared with that of normal healthy bitches still this treatment
protocol can be used successfully in treatment of canine pyometra to conserve
the breeding capability of bitches.
Keywords: bitch, prostaglandin,
pyometra, therapeutic efficacy